Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Abigail G. Herrmann"'
Autor:
Raphael Hesse, Maica Llavero Hurtado, Rosemary J. Jackson, Samantha L. Eaton, Abigail G. Herrmann, Marti Colom-Cadena, Makis Tzioras, Declan King, Jamie Rose, Jane Tulloch, Chris-Anne McKenzie, Colin Smith, Christopher M. Henstridge, Douglas Lamont, Thomas M. Wishart, Tara L. Spires-Jones
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-18 (2019)
Abstract Degeneration of synapses in Alzheimer’s disease (AD) strongly correlates with cognitive decline, and synaptic pathology contributes to disease pathophysiology. We recently observed that the strongest genetic risk factor for sporadic AD, ap
Externí odkaz:
https://doaj.org/article/ad825fe296684195b97f38283374885a
Autor:
Eleanor K. Pickett, Abigail G. Herrmann, Jamie McQueen, Kimberly Abt, Owen Dando, Jane Tulloch, Pooja Jain, Sophie Dunnett, Sadaf Sohrabi, Maria P. Fjeldstad, Will Calkin, Leo Murison, Rosemary J. Jackson, Makis Tzioras, Anna Stevenson, Marie d’Orange, Monique Hooley, Caitlin Davies, Marti Colom-Cadena, Alejandro Anton-Fernandez, Declan King, Iris Oren, Jamie Rose, Chris-Anne McKenzie, Elizabeth Allison, Colin Smith, Oliver Hardt, Christopher M. Henstridge, Giles E. Hardingham, Tara L. Spires-Jones
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3592-3604.e5 (2019)
Summary: A key knowledge gap blocking development of effective therapeutics for Alzheimer’s disease (AD) is the lack of understanding of how amyloid beta (Aβ) peptide and pathological forms of the tau protein cooperate in causing disease phenotype
Externí odkaz:
https://doaj.org/article/5c607706c23f4f7d92a682e925ca0372
Autor:
Lujia Zhou, Joseph McInnes, Keimpe Wierda, Matthew Holt, Abigail G. Herrmann, Rosemary J. Jackson, Yu-Chun Wang, Jef Swerts, Jelle Beyens, Katarzyna Miskiewicz, Sven Vilain, Ilse Dewachter, Diederik Moechars, Bart De Strooper, Tara L. Spires-Jones, Joris De Wit, Patrik Verstreken
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Mislocalisation of tau occurs in several neurodegenerative diseases and is thought to contribute to synaptic function. The authors show that presynaptically, tau binds to synaptic vesicles via the N-terminus which contributes to synaptic dysfunction.
Externí odkaz:
https://doaj.org/article/29d0e0f57e0642e99099f85ef88b2518
Autor:
Pooja Jain, Jane Tulloch, Abigail G. Herrmann, Tara L. Spires-Jones, Anna J. Stevenson, Olga Netsyk, Oliver Hardt, Iris Oren, Eleanor K. Pickett
Publikováno v:
Tulloch, J, Netsyk, O, Pickett, E, Herrmann, A, Jain, P, Stevenson, A, Oren, I, Hardt, O & Spires-Jones, T 2020, ' Maintained memory and long-term potentiation in a mouse model of Alzheimer’s disease with both amyloid pathology and human tau ', European Journal of Neuroscience . https://doi.org/10.1111/ejn.14918
European Journal of Neuroscience
European Journal of Neuroscience
One of the key knowledge gaps in the field of Alzheimer's disease research is the lack of understanding of how amyloid beta and tau cooperate to cause neurodegeneration. We recently generated a mouse model (APP/PS1 + Tau) that develops amyloid plaque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a042a42f3702fbf4b48111c4dbfa2a
https://www.pure.ed.ac.uk/ws/files/156892620/Tulloch2020_ACCEPTED_FOR_PURE.pdf
https://www.pure.ed.ac.uk/ws/files/156892620/Tulloch2020_ACCEPTED_FOR_PURE.pdf
Autor:
Tara L. Spires-Jones, Jane Tulloch, Pooja Jain, Olga Netsyk, Anna J. Stevenson, Iris Oren, Oliver Hardt, Abigail G. Herrmann, Eleanor K. Pickett
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7453ff77f8ae226fe5ab183b48c81e4a
https://doi.org/10.1111/ejn.14918/v2/response1
https://doi.org/10.1111/ejn.14918/v2/response1
Autor:
Christopher M. Henstridge, Raphael Hesse, Douglas J. Lamont, Martí Colom-Cadena, Jane Tulloch, Jamie Rose, Samantha L. Eaton, Tara L. Spires-Jones, Chris-Anne McKenzie, Abigail G. Herrmann, Thomas M. Wishart, Makis Tzioras, Declan King, Colin Smith, Rosemary J. Jackson, Maica Llavero Hurtado
Publikováno v:
Acta Neuropathologica Communications
Hesse, R, Llavero Hurtado, M, Jackson, R J, Eaton, S L, Herrmann, A G, Colom-Cadena, M, Tzioras, M, King, D, Rose, J, Tulloch, J, McKenzie, C-A, Smith, C, Henstridge, C M, Lamont, D, Wishart, T M & Spires-Jones, T L 2019, ' Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype ', Acta Neuropathologica Communications, vol. 7, 214 . https://doi.org/10.1186/s40478-019-0847-7
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-18 (2019)
Hesse, R, Llavero Hurtado, M, Jackson, R J, Eaton, S L, Herrmann, A G, Colom-Cadena, M, Tzioras, M, King, D, Rose, J, Tulloch, J, McKenzie, C-A, Smith, C, Henstridge, C M, Lamont, D, Wishart, T M & Spires-Jones, T L 2019, ' Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype ', Acta Neuropathologica Communications, vol. 7, 214 . https://doi.org/10.1186/s40478-019-0847-7
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-18 (2019)
Degeneration of synapses in Alzheimer’s disease (AD) strongly correlates with cognitive decline, and synaptic pathology contributes to disease pathophysiology. We recently discovered that the strongest genetic risk factor for sporadic AD, apolipopr
Autor:
Joris de Wit, Sven Vilain, Keimpe D. Wierda, Abigail G. Herrmann, Matthew Holt, Yu-Chun Wang, Patrik Verstreken, Bart De Strooper, Jelle Beyens, Ilse Dewachter, Lujia Zhou, Tara L. Spires-Jones, Diederik Moechars, Joseph McInnes, Jef Swerts, Rosemary J. Jackson, Katarzyna Miskiewicz
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications
Zhou, L, McInnes, J, Wierda, K, Holt, M, Herrmann, A G, Jackson, R J, Wang, Y-C, Swerts, J, Beyens, J, Miskiewicz, K, Vilain, S, Dewachter, I, Moechars, D, De Strooper, B, Spires-Jones, T L, De Wit, J & Verstreken, P 2017, ' Tau association with synaptic vesicles causes presynaptic dysfunction ', Nature Communications, vol. 8, 15295 . https://doi.org/10.1038/ncomms15295
Nature Communications
Zhou, L, McInnes, J, Wierda, K, Holt, M, Herrmann, A G, Jackson, R J, Wang, Y-C, Swerts, J, Beyens, J, Miskiewicz, K, Vilain, S, Dewachter, I, Moechars, D, De Strooper, B, Spires-Jones, T L, De Wit, J & Verstreken, P 2017, ' Tau association with synaptic vesicles causes presynaptic dysfunction ', Nature Communications, vol. 8, 15295 . https://doi.org/10.1038/ncomms15295
Tau is implicated in more than 20 neurodegenerative diseases, including Alzheimer's disease. Under pathological conditions, Tau dissociates from axonal microtubules and missorts to pre- and postsynaptic terminals. Patients suffer from early synaptic
Autor:
C. McKenzie, Jane Tulloch, Monique Hooley, Rosemary J. Jackson, Sadaf Sohrabi, Marie d'Orange, Elizabeth Allison, Kimberly Abt, Makis Tzioras, Anna J. Stevenson, Maria P. Fjeldstad, Sophie Dunnett, Will Calkin, Colin Smith, Giles E. Hardingham, Owen Dando, Caitlin Davies, Leo Murison, Eleanor K. Pickett, Tara L. Spires-Jones, Iris Oren, Christopher M. Henstridge, Jamie McQueen, Abigail G. Herrmann, Oliver Hardt, Jamie Rose, Pooja Jain
Publikováno v:
SSRN Electronic Journal.
SummaryOne of the key knowledge gaps blocking development of effective therapeutics for Alzheimer’s disease (AD) is the lack of understanding of how amyloid beta (Aβ) and tau cooperate in causing disease phenotypes. Within a mouse tau deficient ba
Publikováno v:
Journal of Neuropathology and Experimental Neurology
Borger, E, Herrmann, A, Mann, D A, Spires-Jones, T & Gunn-Moore, F 2014, ' The Calcium-Binding Protein EFhd2 Modulates Synapse Formation In Vitro and Is Linked to Human Dementia ', Journal of Neuropathology and Experimental Neurology, vol. 73, no. 12, pp. 1166-1182 . https://doi.org/10.1097/NEN.0000000000000138
Scopus-Elsevier
Borger, E, Herrmann, A, Mann, D A, Spires-Jones, T & Gunn-Moore, F 2014, ' The Calcium-Binding Protein EFhd2 Modulates Synapse Formation In Vitro and Is Linked to Human Dementia ', Journal of Neuropathology and Experimental Neurology, vol. 73, no. 12, pp. 1166-1182 . https://doi.org/10.1097/NEN.0000000000000138
Scopus-Elsevier
Supplemental digital content is available in the text.
EFhd2 is a calcium-binding adaptor protein that has been found to be associated with pathologically aggregated tau in the brain in Alzheimer disease and in a mouse model of frontotemporal de
EFhd2 is a calcium-binding adaptor protein that has been found to be associated with pathologically aggregated tau in the brain in Alzheimer disease and in a mouse model of frontotemporal de
Autor:
Rosemary J, Jackson, Nikita, Rudinskiy, Abigail G, Herrmann, Shaun, Croft, JeeSoo Monica, Kim, Veselina, Petrova, Juan Jose, Ramos-Rodriguez, Rose, Pitstick, Susanne, Wegmann, Monica, Garcia-Alloza, George A, Carlson, Bradley T, Hyman, Tara L, Spires-Jones
Publikováno v:
The European Journal of Neuroscience
Alzheimer's disease is characterized by the presence of aggregates of amyloid beta (Aβ) in senile plaques and tau in neurofibrillary tangles, as well as marked neuron and synapse loss. Of these pathological changes, synapse loss correlates most stro