Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Abigail Fosdick"'
1
Pharmacokinetic and Pharmacodynamic Properties of GS-9620, a Novel Toll-Like Receptor 7 Agonist, Demonstrate Interferon-Stimulated Gene Induction without Detectable Serum Interferon at Low Oral Doses
Autor: Daniel B. Tumas, Joseph Hesselgesser, Christian R. Frey, Randall L. Halcomb, Jim Zheng, Abigail Fosdick, Stefan Pflanz, Grushenka H.I. Wolfgang
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 348:96-105
GS-9620 [8-(3-(pyrrolidin-1-ylmethyl)benzyl)-4-amino-2-butoxy-7,8-dihydropteridin-6(5H)-one] is a potent, orally bioavailable small-molecule agonist of Toll-like receptor 7 (TLR7) developed for finite treatment of chronic hepatitis B viral (HBV) infe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b786234674b209884a301105c9108609
https://doi.org/10.1124/jpet.113.207878
Zobrazit plný text záznamu
2
Assessment of two external telemetry systems (PhysioJacket™ and JET™) in beagle dogs with telemetry implants
Autor: Bernd A. Bruenner, Hugo M. Vargas, Ra'Shun Conner, Abigail Fosdick, Jian Jiang, Ray W. Chui
Publikováno v: Journal of Pharmacological and Toxicological Methods. 60:58-68
Introduction Regulatory guidelines recommend the use of conscious, unrestrained animals for comprehensive cardiovascular safety assessment of a new therapeutic agent. Cardiovascular safety pharmacology studies normally use internal telemetry (surgica
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a6b9bfca336f9cad0d67f60b914218
https://doi.org/10.1016/j.vascn.2009.04.196
Zobrazit plný text záznamu
3
Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B
Autor: Grushenka H.I. Wolfgang, Dalal AlDeghaither, Peng Yue, Christine A. Bellezza, Li Li, Randall L. Halcomb, Stephane Daffis, Jim Zheng, Abigail Fosdick, Katherine H. Liu, Linta M. Thampi, Bud C. Tennant, Baldwin Bh, Daniel B. Tumas, Stephan Menne, Paul J. Cote, Simon P. Fletcher
Publikováno v: Journal of hepatology. 62(6)
Background & Aims New therapies for chronic hepatitis B (CHB) are urgently needed since current treatments rarely lead to cure. We evaluated whether the oral small molecule toll-like receptor (TLR7) agonist GS-9620 could induce durable antiviral effi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21cdda822feb1328b9890b9685f9383
https://pubmed.ncbi.nlm.nih.gov/25559326
Zobrazit plný text záznamu
4
GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees
Autor: Robert E. Lanford, Jim Zheng, Randall L. Halcomb, Deborah Chavez, Vida L. Hodara, Grushenka H.I. Wolfgang, Abigail Fosdick, Kathleen M. Brasky, Daniel B. Tumas, Luis D. Giavedoni, Bernadette Guerra, Christian R. Frey
Publikováno v: Gastroenterology. 144(7)
Background & Aims Direct-acting antiviral agents suppress hepatitis B virus (HBV) load, but they require life-long use. Stimulation of the innate immune system could increase its ability to control the virus and have long-lasting effects after a fini
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b129f0e9d932bf5a42dcb916364d9c
https://pubmed.ncbi.nlm.nih.gov/23710602
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje