Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Abigail F. Groff"'
Autor:
Adrianna K. San Roman, Alexander K. Godfrey, Helen Skaletsky, Daniel W. Bellott, Abigail F. Groff, Hannah L. Harris, Laura V. Blanton, Jennifer F. Hughes, Laura Brown, Sidaly Phou, Ashley Buscetta, Paul Kruszka, Nicole Banks, Amalia Dutra, Evgenia Pak, Patricia C. Lasutschinkow, Colleen Keen, Shanlee M. Davis, Nicole R. Tartaglia, Carole Samango-Sprouse, Maximilian Muenke, David C. Page
Publikováno v:
Cell Genomics, Vol 3, Iss 2, Pp 100259- (2023)
Summary: The “inactive” X chromosome (Xi) has been assumed to have little impact, in trans, on the “active” X (Xa). To test this, we quantified Xi and Xa gene expression in individuals with one Xa and zero to three Xis. Our linear modeling re
Externí odkaz:
https://doaj.org/article/a25725f53e0c4b88aad1b61692c510c9
Autor:
Jordan P. Lewandowski, Gabrijela Dumbović, Audrey R. Watson, Taeyoung Hwang, Emily Jacobs-Palmer, Nydia Chang, Christian Much, Kyle M. Turner, Christopher Kirby, Nimrod D. Rubinstein, Abigail F. Groff, Steve C. Liapis, Chiara Gerhardinger, Assaf Bester, Pier Paolo Pandolfi, John G. Clohessy, Hopi E. Hoekstra, Martin Sauvageau, John L. Rinn
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-35 (2020)
Abstract Background Several long noncoding RNAs (lncRNAs) have been shown to function as components of molecular machines that play fundamental roles in biology. While the number of annotated lncRNAs in mammalian genomes has greatly expanded, studyin
Externí odkaz:
https://doaj.org/article/c0afc736c1d14340901a97d94751f3ae
Autor:
Jordan P. Lewandowski, James C. Lee, Taeyoung Hwang, Hongjae Sunwoo, Jill M. Goldstein, Abigail F. Groff, Nydia P. Chang, William Mallard, Adam Williams, Jorge Henao-Meija, Richard A. Flavell, Jeannie T. Lee, Chiara Gerhardinger, Amy J. Wagers, John L. Rinn
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
LncRNA loci potentially contain multiple modes that can exert function, including DNA regulatory elements. Here, the authors generated genetic models in mice to dissect the role of the syntenically conserved lncRNA Firre in the context of hematopoies
Externí odkaz:
https://doaj.org/article/ae0f94d7e6434786ac485113730f81c4
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-14 (2018)
Abstract Background Recently, it has become clear that some promoters function as long-range regulators of gene expression. However, direct and quantitative assessment of enhancer activity at long intergenic noncoding RNA (lincRNA) or mRNA gene bodie
Externí odkaz:
https://doaj.org/article/1a21e73afd074263a18e41a2df846006
Autor:
Roland Elling, Elektra K. Robinson, Barbara Shapleigh, Stephen C. Liapis, Sergio Covarrubias, Sol Katzman, Abigail F. Groff, Zhaozhao Jiang, Shiuli Agarwal, Mona Motwani, Jennie Chan, Shruti Sharma, Elizabeth J. Hennessy, Garret A. FitzGerald, Michael T. McManus, John L. Rinn, Katherine A. Fitzgerald, Susan Carpenter
Publikováno v:
Cell Reports, Vol 25, Iss 6, Pp 1511-1524.e6 (2018)
Summary: An inducible gene expression program is a hallmark of the host inflammatory response. Recently, long intergenic non-coding RNAs (lincRNAs) have been shown to regulate the magnitude, duration, and resolution of these responses. Among these is
Externí odkaz:
https://doaj.org/article/9d6e33fd6acd48828a125c653a1219ae
Autor:
Abigail F. Groff, Diana B. Sanchez-Gomez, Marcela M.L. Soruco, Chiara Gerhardinger, A. Rasim Barutcu, Eric Li, Lara Elcavage, Olivia Plana, Lluvia V. Sanchez, James C. Lee, Martin Sauvageau, John L. Rinn
Publikováno v:
Cell Reports, Vol 16, Iss 8, Pp 2178-2186 (2016)
The Linc-p21 locus, encoding a long non-coding RNA, plays an important role in p53 signaling, cell-cycle regulation, and tumor suppression. However, despite extensive study, confusion exists regarding its mechanism of action: is activity driven by th
Externí odkaz:
https://doaj.org/article/b97cea6fc71b4eaeb775493f94628854
Publikováno v:
Human Reproduction. 36
Study question What role does the X chromosome play in early embryo metabolism? Does X chromosome copy number contribute to sex differences in early embryonic metabolism? Summary answer Chromosome X contains several metabolism-related genes that are
Autor:
Jaimin S. Shah, Abigail F. Groff, Angela Q. Leung, Alan S. Penzias, Denny Sakkas, Ann Korkidakis
Publikováno v:
Fertility and Sterility. 116:e149-e150
Autor:
Christophe Bourges, James Lee, Abigail F. Groff, Chris Wallace, Tanmay Anand, Chiara Gerhardinger, Oliver S. Burren, Madeline W Epping, Kenneth G. C. Smith, Anna Hutchinson, Theodore Hu, John L. Rinn, Kaia Mattioli
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 5, Pp n/a-n/a (2020)
EMBO Molecular Medicine
EMBO Molecular Medicine
Deriving mechanisms of immune‐mediated disease from GWAS data remains a formidable challenge, with attempts to identify causal variants being frequently hampered by strong linkage disequilibrium. To determine whether causal variants could be identi
Autor:
Chris Wallace, Kaia Mattioli, Madeline W Epping, Kenneth G. C. Smith, Theodore Hu, John L. Rinn, Anna Hutchinson, James Lee, Christophe Bourges, Chiara Gerhardinger, Tanmay Anand, Abigail F. Groff, Oliver S. Burren
Deriving mechanisms of immune-mediated disease from GWAS data remains a formidable challenge, with attempts to identify causal variants being frequently hampered by strong linkage disequilibrium. To determine whether causal variants could be identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c19a0e72f8307e461511e9fe142465d