DNA methylation-based profiling for paediatric CNS tumour diagnosis and treatment: a population-based study

Autor: Martin Sill, Jessica C Pickles, Abigail F Peary, Mark Kristiansen, David T.W. Jones, Steven C. Clifford, Dariusz Ladon, David A Hilton, Darren Hargrave, SA Yasin, David Capper, Nitika Rathi, Aimee Avery, Olumide Ogunbiyi, Amy R Fairchild, Marie Edwards, Lawrence Doey, Kathreena M Kurian, G. Alistair Lammie, Chris Jones, Antonia Torgersen, Ashirwad Merve, Lorelle Brownlee, Rebecca M Hill, James A. R. Nicoll, Yura Grabovska, Azzam Ismail, Frances Rae, Thomas S. Jacques, Daniel Williamson, Aruna Chakrabarty, Clara Limback-Stanic, Tabitha Bloom, Safa Al-Sarraj, Jamie Gonzalez Zapata, Catherine Rowe, Leslie R. Bridges, Stefan M. Pfister, Carryl Dryden, Saira W. Ahmed, Khaja Syed, Lisa Wilkhu, Colin Smith, Thomas J Stone, Paul N Johns, Andreas von Deimling, Matthew Clarke, Clare Mitchell, Jane Chalker

Publikováno v: Pickles, J C, Fairchild, A R, Stone, T J, Brownlee, L, Merve, A, Yasin, S A, Avery, A, Ahmed, S W, Ogunbiyi, O, Gonzalez Zapata, J, Peary, A F, Edwards, M, Wilkhu, L, Dryden, C, Ladon, D, Kristiansen, M, Rowe, C, Kurian, K M, Nicoll, J A R, Mitchell, C, Bloom, T, Hilton, D A, Al-Sarraj, S, Doey, L, Johns, P N, Bridges, L R, Chakrabarty, A, Ismail, A, Rathi, N, Syed, K, Lammie, G A, Limback-Stanic, C, Smith, C, Torgersen, A, Rae, F, Hill, R M, Clifford, S C, Grabovska, Y, Williamson, D, Clarke, M, Jones, C, Capper, D, Sill, M, von Deimling, A, Pfister, S M, Jones, D T W, Hargrave, D, Chalker, J & Jacques, T S 2020, ' DNA methylation-based profiling for paediatric CNS tumour diagnosis and treatment : a population-based study ', The Lancet Child and Adolescent Health, vol. 4, no. 2, pp. 121-130 . https://doi.org/10.1016/S2352-4642(19)30342-6

Summary Background Marked variation exists in the use of genomic data in tumour diagnosis, and optimal integration with conventional diagnostic technology remains uncertain despite several studies reporting improved diagnostic accuracy, selection for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83379610827dcf35a669159c2f2b68f3
https://doi.org/10.1016/s2352-4642(19)30342-6