Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Abigail, Ngoepe"'
Autor:
Robert Krause, Paul Ogongo, Liku Tezera, Mohammed Ahmed, Ian Mbano, Mark Chambers, Abigail Ngoepe, Magalli Magnoumba, Daniel Muema, Farina Karim, Khadija Khan, Kapongo Lumamba, Kievershen Nargan, Rajhmun Madansein, Adrie Steyn, Alex K. Shalek, Paul Elkington, Al Leslie
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract B cells are important in tuberculosis (TB) immunity, but their role in the human lung is understudied. Here, we characterize B cells from lung tissue and matched blood of patients with TB and found they are decreased in the blood and increas
Externí odkaz:
https://doaj.org/article/23c37a25fe0246aca37d4431b56b7432
Autor:
Robert Krause, Jumari Snyman, Hwa Shi-Hsia, Daniel Muema, Farina Karim, Yashica Ganga, Abigail Ngoepe, Yenzekile Zungu, Inbal Gazy, Mallory Bernstein, Khadija Khan, Matilda Mazibuko, Ntombifuthi Mthabela, Dirhona Ramjit, COMMIT-KZN Team, Oliver Limbo, Joseph Jardine, Devin Sok, Ian A Wilson, Willem Hanekom, Alex Sigal, Henrik Kløverpris, Thumbi Ndung'u, Alasdair Leslie
Publikováno v:
eLife, Vol 11 (2022)
Background: HIV infection dysregulates the B cell compartment, affecting memory B cell formation and the antibody response to infection and vaccination. Understanding the B cell response to SARS-CoV-2 in people living with HIV (PLWH) may explain the
Externí odkaz:
https://doaj.org/article/9e85d121845c4a7ba7f4e109a7030fe9
Autor:
Rabiah Fardoos, Sarah K. Nyquist, Osaretin E. Asowata, Samuel W. Kazer, Alveera Singh, Abigail Ngoepe, Jennifer Giandhari, Ntombifuthi Mthabela, Dirhona Ramjit, Samita Singh, Farina Karim, Søren Buus, Frank Anderson, J. Zachary Porterfield, Andile L. Sibiya, Rishan Bipath, Kumeshan Moodley, Warren Kuhn, Bonnie Berger, Son Nguyen, Tulio de Oliveira, Thumbi Ndung’u, Philip Goulder, Alex K. Shalek, Alasdair Leslie, Henrik N. Kløverpris
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Lymphoid tissues are an important HIV reservoir site that persists in the face of antiretroviral therapy and natural immunity. Targeting these reservoirs by harnessing the antiviral activity of local tissue-resident memory (TRM) CD8+ T-cells is of gr
Externí odkaz:
https://doaj.org/article/2214efc1e1c44dd5be878bda8705a958
Autor:
Rabiah Fardoos, Osaretin E. Asowata, Nicholas Herbert, Sarah K. Nyquist, Yenzekile Zungu, Alveera Singh, Abigail Ngoepe, Ian M. Mbano, Ntombifuthi Mthabela, Dirhona Ramjit, Farina Karim, Warren Kuhn, Fusi G. Madela, Vukani T. Manzini, Frank Anderson, Bonnie Berger, Tune H. Pers, Alex K. Shalek, Alasdair Leslie, Henrik N. Kløverpris
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
SARS-CoV-2 infects epithelial cells of the human gastrointestinal (GI) tract and causes related symptoms. HIV infection impairs gut homeostasis and is associated with an increased risk of COVID-19 fatality. To investigate the potential link between t
Externí odkaz:
https://doaj.org/article/393306dcc3c24409b817c7996c447f25
Autor:
Osaretin E. Asowata, Alveera Singh, Abigail Ngoepe, Nicholas Herbert, Rabiah Fardoos, Kavidha Reddy, Yenzekile Zungu, Faith Nene, Ntombifuthi Mthabela, Dirhona Ramjit, Farina Karim, Katya Govender, Thumbi Ndung’u, J. Zachary Porterfield, John H. Adamson, Fusi G. Madela, Vukani T. Manzini, Frank Anderson, Alasdair Leslie, Henrik N. Kløverpris
Publikováno v:
JCI Insight, Vol 6, Iss 22 (2021)
HIV infection in the human gastrointestinal (GI) tract is thought to be central to HIV progression, but knowledge of this interaction is primarily limited to cohorts within Westernized countries. Here, we present a large cohort recruited from high HI
Externí odkaz:
https://doaj.org/article/37e416fff28f48b7afb827c4e765515f
Autor:
Gila Lustig, Sandile Cele, Farina Karim, Anne Derache, Abigail Ngoepe, Khadija Khan, Bernadett I Gosnell, Mahomed-Yunus S Moosa, Ntombi Ntshuba, Suzaan Marais, Prakash M Jeena, Katya Govender, John Adamson, Henrik Kløverpris, Ravindra K Gupta, Rohen Harrichandparsad, Vinod B Patel, Alex Sigal
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009871 (2021)
HIV cerebrospinal fluid (CSF) escape, where HIV is suppressed in blood but detectable in CSF, occurs when HIV persists in the CNS despite antiretroviral therapy (ART). To determine the virus producing cell type and whether lowered CSF ART levels are
Externí odkaz:
https://doaj.org/article/a1fcfa49647c48ec8249fe5457393dfd
Autor:
Julia Roider, Abigail Ngoepe, Maximilian Muenchhoff, Emily Adland, Andreas Groll, Thumbi Ndung'u, Henrik Kløverpris, Philip Goulder, Alasdair Leslie
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Pediatric slow progressors (PSP) are rare ART-naïve, HIV-infected children who maintain high CD4 T-cell counts and low immune activation despite persistently high viral loads. Using a well-defined cohort of PSP, we investigated the role of regulator
Externí odkaz:
https://doaj.org/article/5daad35785544546808d63e7ccd1c04d
Autor:
Julia Roider, Takashi Maehara, Abigail Ngoepe, Duran Ramsuran, Maximilian Muenchhoff, Emily Adland, Toby Aicher, Samuel W. Kazer, Pieter Jooste, Farina Karim, Warren Kuhn, Alex K. Shalek, Thumbi Ndung'u, Lynn Morris, Penny L. Moore, Shiv Pillai, Henrik Kløverpris, Philip Goulder, Alasdair Leslie
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Broadly neutralizing antibodies (bnAbs) against HIV-1 are an effective means of preventing transmission. To better understand the mechanisms by which HIV-specific bnAbs naturally develop, we investigated blood and lymphoid tissue in pediatric infecti
Externí odkaz:
https://doaj.org/article/c66447ad8ffe40e48105ac1cf348eb35
Autor:
Rabiah, Fardoos, Sarah K, Nyquist, Osaretin E, Asowata, Samuel W, Kazer, Alveera, Singh, Abigail, Ngoepe, Jennifer, Giandhari, Ntombifuthi, Mthabela, Dirhona, Ramjit, Samita, Singh, Farina, Karim, Søren, Buus, Frank, Anderson, J Zachary, Porterfield, Andile L, Sibiya, Rishan, Bipath, Kumeshan, Moodley, Warren, Kuhn, Bonnie, Berger, Son, Nguyen, Tulio, de Oliveira, Thumbi, Ndung'u, Philip, Goulder, Alex K, Shalek, Alasdair, Leslie, Henrik N, Kløverpris
Publikováno v:
Frontiers in immunology. 13
Lymphoid tissues are an important HIV reservoir site that persists in the face of antiretroviral therapy and natural immunity. Targeting these reservoirs by harnessing the antiviral activity of local tissue-resident memory (TsubRM/sub) CD8sup+/supT-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c1f56c5e989ab6c4a00d40e98dc97791
https://pubmed.ncbi.nlm.nih.gov/36330531
https://pubmed.ncbi.nlm.nih.gov/36330531
Autor:
Rabiah Fardoos, Sarah K. Nyquist, Osaretin E. Asowata, Samuel W. Kazer, Alveera Singh, Abigail Ngoepe, Janifer Giandhari, Ntombifuthi Mthabela, Dirhona Ramjit, Samita Singh, Farina Karim, Søren Buus, Frank Anderson, James Z. Porterfield, Andile L. Sibiya, Rishan Bipath, Kumeshan Moodley, Warren Kuhn, Bonnie Berger, Son Nguyen, Tulio de Oliveira, Thumbi Ndung’u, Philip Goulder, Alex K. Shalek, Alasdair Leslie, Henrik N. Kløverpris
Lymphoid tissues are an important HIV reservoir site that persists in the face of antiretroviral therapy and natural immunity. Targeting these reservoirs by harnessing the antiviral activity of local tissue resident memory ( TRM) CD8+ T-cells is of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c01e5267b5ba1bee2cc1112d6bf88593
https://doi.org/10.1101/2021.11.04.467061
https://doi.org/10.1101/2021.11.04.467061
