Výsledky vyhledávání - "Abigael T. Gemo"

ANCCA/ATAD2 Overexpression Identifies Breast Cancer Patients with Poor Prognosis, Acting to Drive Proliferation and Survival of Triple-Negative Cells through Control of B-Myb and EZH2

Autor: Ekaterina V. Kalashnikova, Hongwu Chen, Abigael T. Gemo, Clifford G. Tepper, Robert D. Cardiff, June X. Zou, Nicholas P Andrews, Alexey S. Revenko, Alexander D. Borowsky

Publikováno v: Cancer Research. 70:9402-9412

Chromatin coregulators are important factors in tumorigenesis and cancer progression. ANCCA is an AAA+ ATPase and a bromodomain-containing nuclear coactivator for the estrogen and androgen receptors that is crucial for assembly of chromatin-modifying

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455b1c9083c2c198ba271be732d91a69
https://doi.org/10.1158/0008-5472.can-10-1199

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Chromatin Loading of E2F-MLL Complex by Cancer-Associated Coregulator ANCCA via Reading a Specific Histone Mark

Autor: Ekaterina V. Kalashnikova, Abigael T. Gemo, June X. Zou, Alexey S. Revenko, Hongwu Chen

Publikováno v: Molecular and Cellular Biology. 30:5260-5272

Histone modifications are regarded as the carrier of epigenetic memory through cell divisions. How the marks facilitate cell cycle-dependent gene expression is poorly understood. The evolutionarily conserved AAA ATPase ANCCA (AAA nuclear coregulator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a23e20eac66c45770334e06974edc023
https://doi.org/10.1128/mcb.00484-10

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ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERα, is required for coregulator occupancy and chromatin modification

Autor: Alexey S. Revenko, Abigael T. Gemo, June X. Zou, Li B. Li, Hongwu Chen

Publikováno v: Proceedings of the National Academy of Sciences. 104:18067-18072

AAA+ proteins play crucial roles in diverse biological processes via their ATPase-driven remodeling of macromolecular complexes. Here we report our identification of an evolutionarily conserved AAA+ protein, ANCCA/pro2000, endowed with a bromodomain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c9647d51c6cd1719354ee4739a7568e
https://doi.org/10.1073/pnas.0705814104

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Abstract 1407: FPA144, a therapeutic monoclonal antibody targeting the FGFR2b receptor, promotes antibody dependent cell-mediated cytotoxicity and stimulates sensitivity to PD-1 in the 4T1 syngeneic tumor model

Autor: Susan P. Foy, Barbara Sennino, Toni Rose Hidalgo, Janine Powers, Kisten Pierce, Thomas Brennan, Abigael T. Gemo, Servando Palencia

Publikováno v: Cancer Research. 76:1407-1407

Five Prime Therapeutics, Inc. has developed an FGFR2b-specific humanized monoclonal antibody, FPA144, to treat patients with cancer bearing overexpression of the FGFR2b receptor, and is currently in clinical trials as a single agent for gastric cance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3e00ea43f4ed08961035d7e157df3fa
https://doi.org/10.1158/1538-7445.am2016-1407

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Androgen-induced coactivator ANCCA mediates specific androgen receptor signaling in prostate cancer

Autor: Abigael T. Gemo, Clifford G. Tepper, Linlang Guo, June X. Zou, Hongwu Chen, Alexey S. Revenko, Hsing Jien Kung

Publikováno v: Cancer research. 69(8)

Androgen receptor (AR) plays a pivotal role in prostate cancer, primarily by regulating different gene expression programs elicited by androgen, which is important for cancer cell proliferation, survival, and differentiation. It is believed that the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e54e630aec22157b2ef27ff1f13a64
https://pubmed.ncbi.nlm.nih.gov/19318566

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Abstract 2845: Expression of FGFR2b in gastric cancer as measured by immunohistochemistry with a highly specific monoclonal antibody

Autor: Kristen L. Pierce, Amit Deshpande, Bradley A. Stohr, Servando Palencia, David I. Bellovin, Gerrit Los, Tina Giese, Abigael T. Gemo

Publikováno v: Cancer Research. 74:2845-2845

Gastric cancer is the second leading cause of death from cancer worldwide. Amplification of the FGFR2 gene has been reported in ∼ 5 to 7% of gastric cancers, and several studies have also reported overexpression of the FGFR2 protein using immunohis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ba170976d0cef27c238479aa4663f37
https://doi.org/10.1158/1538-7445.am2014-2845

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Abstract 5446: FPA144: A therapeutic antibody for treating patients with gastric cancers bearing FGFR2 gene amplification

Autor: Carol Huang, Kristen L. Pierce, David I. Bellovin, Amit Deshpande, Gerrit Los, Thomas Brennan, Abigael T. Gemo, Namrata Patil, Servando Palencia

Publikováno v: Cancer Research. 74:5446-5446

A subset of patients with gastric cancer have an amplification of the receptor tyrosine kinase fibroblast growth factor receptor 2 (FGFR2) gene. The amplification is most common in the diffuse type of gastric cancer and its presence correlates with p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d363bd52ee66c4bb802ce626bc5a2e32
https://doi.org/10.1158/1538-7445.am2014-5446

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FPA144, a humanized monoclonal antibody for both FGFR2-amplified and nonamplified, FGFR2b-overexpressing gastric cancer patients

Autor: David Bellovin, W. Michael Kavanaugh, Tina Giese, Kevin P. Baker, Servando Palencia, Carol Huang, Abigael T. Gemo, Julie Hambleton, Gerrit Los, Thomas Brennan, Namrata Patil, Amit M. Deshpande, Bradley A. Stohr, Kristen L. Pierce

Publikováno v: Journal of Clinical Oncology. 32:e15074-e15074

e15074 Background: Amplification of the Fibroblast Growth Factor Receptor 2 (FGFR2) gene is reported in ~5% of gastric cancer patients and leads to the specific overexpression of the FGFR2b isoform...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e166bc252f9cc8c05095ae0f85594ad
https://doi.org/10.1200/jco.2014.32.15_suppl.e15074

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