Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Abid OU"'
Publikováno v:
Heliyon, Vol 10, Iss 20, Pp e39571- (2024)
Converging evidence from clinical and experimental studies suggest the potential significance of Polo-like kinase 2 (PLK2) in regulating the phosphorylation and toxicity of the Alzheimer's disease (AD)-related protein, amyloid precursor protein (APP)
Externí odkaz:
https://doaj.org/article/3eee8e5bc7f3471ba759b39b42c0d3cf
Autor:
Stefan Bartl, Yuanyun Xie, Nalini Potluri, Ratnesh Kesineni, Katlin Hencak, Louisa Dal Cengio, Katja Balazs, Abid Oueslati, Michela Parth, Nina Salhat, Alberto Siddu, Oskar Smrzka, Francesca Cicchetti, Günther Staffler, Michael R. Hayden, Amber L. Southwell
Publikováno v:
Neurobiology of Disease, Vol 193, Iss , Pp 106444- (2024)
Externí odkaz:
https://doaj.org/article/9f127a6b6c0642d8b90cf4f316b4916a
Autor:
Olivier Lurette, Rebeca Martín-Jiménez, Mehtab Khan, Razan Sheta, Stéphanie Jean, Mia Schofield, Maxime Teixeira, Raquel Rodriguez-Aller, Isabelle Perron, Abid Oueslati, Etienne Hebert-Chatelain
Publikováno v:
Cell Death and Disease, Vol 14, Iss 11, Pp 1-14 (2023)
Abstract Accumulation of α-synuclein aggregates in the substantia nigra pars compacta is central in the pathophysiology of Parkinson’s disease, leading to the degeneration of dopaminergic neurons and the manifestation of motor symptoms. Although s
Externí odkaz:
https://doaj.org/article/c078e0cade00424082d97a16652c017e
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-20 (2023)
Abstract Background Alpha-synuclein (α-syn) aggregation into proteinaceous intraneuronal inclusions, called Lewy bodies (LBs), is the neuropathological hallmark of Parkinson’s disease (PD) and related synucleinopathies. However, the exact role of
Externí odkaz:
https://doaj.org/article/91856d8713d94f67b528da7c9b510847
Autor:
Stefan Bartl, Yuanyun Xie, Nalini Potluri, Ratnesh Kesineni, Katlin Hencak, Louisa Dal Cengio, Katja Balazs, Abid Oueslati, Michela Parth, Nina Salhat, Alberto Siddu, Oskar Smrzka, Francesca Cicchetti, Günther Straffler, Michael R. Hayden, Amber L. Southwell
Publikováno v:
Neurobiology of Disease, Vol 190, Iss , Pp 106376- (2024)
In Huntington disease (HD), the mutant huntingtin (mtHTT) protein is the principal cause of pathological changes that initiate primarily along the cortico-striatal axis. mtHTT is ubiquitously expressed and there is, accordingly, growing recognition t
Externí odkaz:
https://doaj.org/article/4d07a71b09d34d4a99a06f94d8778757
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102738- (2023)
Summary: Studying Parkinson’s disease (PD) is complex due to a lack of cellular models mimicking key aspects of protein pathology. Here, we present a protocol for inducing and monitoring α-synuclein aggregation in living cells using optogenetics.
Externí odkaz:
https://doaj.org/article/b08042b0e55c434dbef3971e2766a5d9
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102486- (2023)
Summary: Generation of functional human dopaminergic (DA) neurons from human induced pluripotent stem cells (hiPSCs) is a crucial tool for modeling dopamine-related human diseases and cell replacement therapies. Here, we present a protocol to combine
Externí odkaz:
https://doaj.org/article/1f3285d140484f579b21e06dacfc5a3f
Autor:
Razan Sheta, Maxime Teixeira, Walid Idi, Marion Pierre, Aurelie de Rus Jacquet, Vincent Emond, Cornelia E. Zorca, Benoît Vanderperre, Thomas M. Durcan, Edward A. Fon, Frédéric Calon, Mohamed Chahine, Abid Oueslati
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract The use of human derived induced pluripotent stem cells (hiPSCs) differentiated to dopaminergic (DA) neurons offers a valuable experimental model to decorticate the cellular and molecular mechanisms of Parkinson’s disease (PD) pathogenesis
Externí odkaz:
https://doaj.org/article/c73c57568ac04220baa369ab6de77226
Publikováno v:
Revue Nature et Technologie, Vol 12, Iss 02 (2022)
Les dattes sont des fruits riches en substances biologiquement actives, ce qui leurs confère un grand intérêt en termes de validation. Dans cette étude nous avons visé les caractéristiques des fruits de deux variétés de Phoenix dactylifera L.
Externí odkaz:
https://doaj.org/article/05f89f3e55c842959c43398e1b829189
Autor:
Laura Martínez-Drudis, Razan Sheta, Rémi Pellegrinato, Salma Loukili, Cyntia Tremblay, Frédéric Calon, Serge Rivest, Abid Oueslati
Publikováno v:
Neurobiology of Disease, Vol 172, Iss , Pp 105833- (2022)
Converging lines of evidence suggest that abnormal accumulation of the kinase Polo-like kinase 2 (PLK2) might play a role in the pathogenesis of Alzheimer's disease (AD), possibly through its role in regulating the amyloid β (Aβ) cascade. In the pr
Externí odkaz:
https://doaj.org/article/91f1f2cff8d44571a70df9624031808a