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Combination of Anti-CD40 and Anti-CD40L Antibodies as Co-Stimulation Blockade in Preclinical Cardiac Xenotransplantation.

Autor: Bender M; Department of Anaesthesiology, University Hospital, LMU Munich, 81377 Munich, Germany., Abicht JM; Department of Anaesthesiology, University Hospital, LMU Munich, 81377 Munich, Germany., Reichart B; Transregional Collaborative Research Center 127, Walter Brendel Centre of Experimental Medicine, LMU Munich, 81377 Munich, Germany., Neumann E; Transregional Collaborative Research Center 127, Walter Brendel Centre of Experimental Medicine, LMU Munich, 81377 Munich, Germany., Radan J; Transregional Collaborative Research Center 127, Walter Brendel Centre of Experimental Medicine, LMU Munich, 81377 Munich, Germany., Mokelke M; Transregional Collaborative Research Center 127, Walter Brendel Centre of Experimental Medicine, LMU Munich, 81377 Munich, Germany., Buttgereit I; Department of Anaesthesiology, University Hospital, LMU Munich, 81377 Munich, Germany., Leuschen M; Transregional Collaborative Research Center 127, Walter Brendel Centre of Experimental Medicine, LMU Munich, 81377 Munich, Germany., Wall F; Transregional Collaborative Research Center 127, Walter Brendel Centre of Experimental Medicine, LMU Munich, 81377 Munich, Germany., Michel S; Department of Cardiac Surgery, University Hospital, LMU Munich, 81377 Munich, Germany.; Munich Heart Alliance, German Center for Cardiovascular Research (DZHK), 81377 Munich, Germany., Ellgass R; Department of Cardiac Surgery, University Hospital, LMU Munich, 81377 Munich, Germany., Steen S; Department of Cardiothoracic Surgery, Lund University and Skåne University Hospital, 22242 Lund, Sweden., Paskevicius A; Department of Cardiothoracic Surgery, Lund University and Skåne University Hospital, 22242 Lund, Sweden., Lange A; Institute of Molecular Animal Breeding and Biotechnology, Gene Center, and Department of Veterinary Sciences, LMU Munich, 81377 Munich, Germany., Kessler B; Institute of Molecular Animal Breeding and Biotechnology, Gene Center, and Department of Veterinary Sciences, LMU Munich, 81377 Munich, Germany., Kemter E; Institute of Molecular Animal Breeding and Biotechnology, Gene Center, and Department of Veterinary Sciences, LMU Munich, 81377 Munich, Germany., Klymiuk N; Institute of Molecular Animal Breeding and Biotechnology, Gene Center, and Department of Veterinary Sciences, LMU Munich, 81377 Munich, Germany., Denner J; Institute of Virology, Free University Berlin, 14163 Berlin, Germany., Godehardt AW; Division of Haematology, Cell and Gene Therapy, Paul-Ehrlich-Institut, 63225 Langen, Germany., Tönjes RR; Division of Haematology, Cell and Gene Therapy, Paul-Ehrlich-Institut, 63225 Langen, Germany., Burgmann JM; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, 30625 Hannover, Germany., Figueiredo C; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, 30625 Hannover, Germany., Milusev A; Department for BioMedical Research (DBMR), University of Bern, 3008 Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences (GCB), University of Bern, 3008 Bern, Switzerland., Zollet V; Department for BioMedical Research (DBMR), University of Bern, 3008 Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences (GCB), University of Bern, 3008 Bern, Switzerland., Salimi-Afjani N; Department for BioMedical Research (DBMR), University of Bern, 3008 Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences (GCB), University of Bern, 3008 Bern, Switzerland., Despont A; Department for BioMedical Research (DBMR), University of Bern, 3008 Bern, Switzerland., Rieben R; Department for BioMedical Research (DBMR), University of Bern, 3008 Bern, Switzerland., Ledderose S; Institute of Pathology, Faculty of Medicine, LMU Munich, 81377 Munich, Germany., Walz C; Institute of Pathology, Faculty of Medicine, LMU Munich, 81377 Munich, Germany., Hagl C; Department of Cardiac Surgery, University Hospital, LMU Munich, 81377 Munich, Germany.; Munich Heart Alliance, German Center for Cardiovascular Research (DZHK), 81377 Munich, Germany., Ayares D; Revivicor, Blacksburg, VA 24060, USA., Wolf E; Institute of Molecular Animal Breeding and Biotechnology, Gene Center, and Department of Veterinary Sciences, LMU Munich, 81377 Munich, Germany.; Center for Innovative Medical Models (CiMM), LMU Munich, 81377 Munich, Germany.; Interfaculty Center for Endocrine and Cardiovascular Disease Network Modelling and Clinical Transfer (ICONLMU), LMU Munich, 81377 Munich, Germany., Schmoeckel M; Department of Cardiac Surgery, University Hospital, LMU Munich, 81377 Munich, Germany., Brenner P; Department of Cardiac Surgery, University Hospital, LMU Munich, 81377 Munich, Germany., Binder U; XL-protein GmbH, 85354 Freising, Germany., Gebauer M; XL-protein GmbH, 85354 Freising, Germany., Skerra A; Chair of Biological Chemistry, School of Life Sciences, Technical University of Munich, 85354 Freising, Germany., Längin M; Department of Anaesthesiology, University Hospital, LMU Munich, 81377 Munich, Germany.

Publikováno v: Biomedicines [Biomedicines] 2024 Aug 22; Vol. 12 (8). Date of Electronic Publication: 2024 Aug 22.

An Approach to Controlling Inflammation and Coagulation in Pig-to-Baboon Cardiac Xenotransplantation.

Autor: Bender M; Department of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany., Reichart B; Transregional Collaborative Research Center 127, Walter Brendel Centre of Experimental Medicine, LMU Munich, Munich, Germany., Figueiredo C; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany., Burgmann JM; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany., Leuschen M; Transregional Collaborative Research Center 127, Walter Brendel Centre of Experimental Medicine, LMU Munich, Munich, Germany., Wall F; Transregional Collaborative Research Center 127, Walter Brendel Centre of Experimental Medicine, LMU Munich, Munich, Germany., Radan J; Transregional Collaborative Research Center 127, Walter Brendel Centre of Experimental Medicine, LMU Munich, Munich, Germany., Neumann E; Transregional Collaborative Research Center 127, Walter Brendel Centre of Experimental Medicine, LMU Munich, Munich, Germany., Mokelke M; Transregional Collaborative Research Center 127, Walter Brendel Centre of Experimental Medicine, LMU Munich, Munich, Germany., Buttgereit I; Department of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany., Michel S; Department of Cardiac Surgery, University Hospital, LMU Munich, Munich, Germany., Ellgass R; Department of Cardiac Surgery, University Hospital, LMU Munich, Munich, Germany., Egerer S; Institute of Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, Munich, Germany., Lange A; Institute of Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, Munich, Germany., Baehr A; Institute of Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, Munich, Germany., Kessler B; Institute of Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, Munich, Germany., Kemter E; Institute of Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, Munich, Germany., Klymiuk N; Institute of Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, Munich, Germany., Denner J; Institute of Virology, Free University Berlin, Berlin, Germany., Godehardt AW; Division of Haematology, Cell and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany., Tönjes RR; Division of Haematology, Cell and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany., Hagl C; Department of Cardiac Surgery, University Hospital, LMU Munich, Munich, Germany., Gebauer M; XL-protein GmbH, Freising, Germany., Binder U; XL-protein GmbH, Freising, Germany., Skerra A; Chair of Biological Chemistry, School of Life Sciences, Technical University of Munich, Freising, Germany., Ayares D; Revivicor, Blacksburg, Virginia, USA., Wolf E; Institute of Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, Munich, Germany.; Center for Innovative Medical Models (CiMM), LMU Munich, Munich, Germany.; Interfaculty Center for Endocrine and Cardiovascular Disease Network Modelling and Clinical Transfer (ICONLMU), LMU Munich, Munich, Germany., Schmoeckel M; Department of Cardiac Surgery, University Hospital, LMU Munich, Munich, Germany., Brenner P; Department of Cardiac Surgery, University Hospital, LMU Munich, Munich, Germany., Längin M; Department of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany., Abicht JM; Department of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany.

Publikováno v: Xenotransplantation [Xenotransplantation] 2024 Jul-Aug; Vol. 31 (4), pp. e12877.

Current Status of Cardiac Xenotransplantation: Report of a Workshop of the German Heart Transplant Centers, Martinsried, March 3, 2023.

Autor: Schmoeckel M; Herzchirurgische Klinik und Poliklinik, LMU Klinikum, LMU München, Germany., Längin M; Klinik für Anaesthesiologie, LMU Klinikum, LMU München, Germany.; DFG-Transregio-Sonderforschungsbereich TR127-Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany., Reichart B; DFG-Transregio-Sonderforschungsbereich TR127-Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany., Abicht JM; Klinik für Anaesthesiologie, LMU Klinikum, LMU München, Germany.; DFG-Transregio-Sonderforschungsbereich TR127-Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany., Bender M; Klinik für Anaesthesiologie, LMU Klinikum, LMU München, Germany.; DFG-Transregio-Sonderforschungsbereich TR127-Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany., Michel S; Herzchirurgische Klinik und Poliklinik, LMU Klinikum, LMU München, Germany.; DFG-Transregio-Sonderforschungsbereich TR127-Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany., Kamla CE; Herzchirurgische Klinik und Poliklinik, LMU Klinikum, LMU München, Germany., Denner J; DFG-Transregio-Sonderforschungsbereich TR127-Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany.; Institut für Virologie, Fachbereich für Veterinärmedizin, Freie Universität Berlin, Berlin, Germany., Tönjes RR; DFG-Transregio-Sonderforschungsbereich TR127-Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany.; Paul-Ehrlich-Institut, Langen, Germany., Schwinzer R; DFG-Transregio-Sonderforschungsbereich TR127-Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany.; Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Medizinische Hochschule Hannover, Hannover, Germany., Marckmann G; DFG-Transregio-Sonderforschungsbereich TR127-Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany.; Institut für Ethik, Geschichte und Theorie der Medizin, LMU München, Germany., Wolf E; DFG-Transregio-Sonderforschungsbereich TR127-Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany.; Lehrstuhl für Molekulare Tierzucht und Biotechnologie, Genzentrum der LMU München, Germany., Brenner P; Herzchirurgische Klinik und Poliklinik, LMU Klinikum, LMU München, Germany.; DFG-Transregio-Sonderforschungsbereich TR127-Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany., Hagl C; Herzchirurgische Klinik und Poliklinik, LMU Klinikum, LMU München, Germany.; DZHK (Deutsches Zentrum für Herz-Kreislauf-Forschung e.V.), Partner Site Munich, Germany.

Publikováno v: The Thoracic and cardiovascular surgeon [Thorac Cardiovasc Surg] 2024 Jun; Vol. 72 (4), pp. 273-284. Date of Electronic Publication: 2023 Dec 28.