Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Abhishek Singharoy"'
Autor:
David Chmielewski, Eric A. Wilson, Grigore Pintilie, Peng Zhao, Muyuan Chen, Michael F. Schmid, Graham Simmons, Lance Wells, Jing Jin, Abhishek Singharoy, Wah Chiu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Coronavirus spike glycoproteins presented on the virion surface mediate receptor binding, and membrane fusion during virus entry and constitute the primary target for vaccine and drug development. How the structure dynamics of the full-lengt
Externí odkaz:
https://doaj.org/article/59f6e796a34541e8ac45dd396b94428c
Autor:
Anasuya Pal, Laura Gonzalez-Malerva, Seron Eaton, Chenxi Xu, Yining Zhang, Dustin Grief, Lydia Sakala, Lilian Nwekwo, Jia Zeng, Grant Christensen, Chitrak Gupta, Ellen Streitwieser, Abhishek Singharoy, Jin G. Park, Joshua LaBaer
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-21 (2023)
Abstract Mutations in the TP53 tumor suppressor gene occur in >80% of the triple-negative or basal-like breast cancer. To test whether neomorphic functions of specific TP53 missense mutations contribute to phenotypic heterogeneity, we characterized p
Externí odkaz:
https://doaj.org/article/a6acf0331a8a45b7b1b002a6026ce9c2
Autor:
Shamayeeta Ray, Samuel P Berry, Eric A Wilson, Casey H Zhang, Mrinal Shekhar, Abhishek Singharoy, Rachelle Gaudet
Publikováno v:
eLife, Vol 12 (2023)
Transporters of the Nramp (Natural resistance-associated macrophage protein) family import divalent transition metal ions into cells of most organisms. By supporting metal homeostasis, Nramps prevent diseases and disorders related to metal insufficie
Externí odkaz:
https://doaj.org/article/31a6a8e80ee44293aea58786ccac961d
Publikováno v:
Current Research in Structural Biology, Vol 4, Iss , Pp 68-77 (2022)
Cryo-electron microscopy (cryo-EM) has produced a number of structural models of the SARS-CoV-2 spike, already prompting biomedical outcomes. However, these reported models and their associated electrostatic potential maps represent an unknown admixt
Externí odkaz:
https://doaj.org/article/f282bd28f44747318e59a3ad51827f3f
Autor:
Ali Dashti, Ghoncheh Mashayekhi, Mrinal Shekhar, Danya Ben Hail, Salah Salah, Peter Schwander, Amedee des Georges, Abhishek Singharoy, Joachim Frank, Abbas Ourmazd
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
There is a great interest in retrieving functional pathways from cryo-EM single-particle data. Here, the authors present an approach that combines cryo-EM with advanced data-analytical methods and molecular dynamics simulations to reveal the function
Externí odkaz:
https://doaj.org/article/a9730a6e4420466a99ccf8fd2dbeaec2
Autor:
Abhishek Singharoy, Chris Chipot, Toru Ekimoto, Kano Suzuki, Mitsunori Ikeguchi, Ichiro Yamato, Takeshi Murata
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
V1-ATPase exemplifies the ubiquitous rotary motor, in which a central shaft DF complex rotates inside a hexagonally arranged catalytic A3B3 complex, powered by the energy from ATP hydrolysis. We have recently reported a number of crystal structures o
Externí odkaz:
https://doaj.org/article/e5583df1bdad4aa188574cf64909c389
Publikováno v:
eLife, Vol 5 (2016)
The chromatophore of purple bacteria is an intracellular spherical vesicle that exists in numerous copies in the cell and that efficiently converts sunlight into ATP synthesis, operating typically under low light conditions. Building on an atomic-lev
Externí odkaz:
https://doaj.org/article/a23c46c1fce34edea5efe5703701e5e7
Publikováno v:
eLife, Vol 5 (2016)
Two structure determination methods, based on the molecular dynamics flexible fitting (MDFF) paradigm, are presented that resolve sub-5 Å cryo-electron microscopy (EM) maps with either single structures or ensembles of such structures. The methods,
Externí odkaz:
https://doaj.org/article/a634c22656b84df4bcb1ce5b496cfa36
Autor:
Stephan Wickles, Abhishek Singharoy, Jessica Andreani, Stefan Seemayer, Lukas Bischoff, Otto Berninghausen, Johannes Soeding, Klaus Schulten, Eli O van der Sluis, Roland Beckmann
Publikováno v:
eLife, Vol 3 (2014)
The integration of most membrane proteins into the cytoplasmic membrane of bacteria occurs co-translationally. The universally conserved YidC protein mediates this process either individually as a membrane protein insertase, or in concert with the Se
Externí odkaz:
https://doaj.org/article/fef72e4b4267452ba2a024b8fb38c170
Publikováno v:
Biochemistry
Cytochrome c(2) (cyt. c(2)) is a major element in electron transfer between redox proteins in bioenergetic membranes. While the interaction between cyt. c(2) and anionic lipids abundant in bioenergetic membranes has been reported, their effect on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daeed8a291bbf8a57343e24381c68c98
https://doi.org/10.1021/acs.biochem.1c00696
https://doi.org/10.1021/acs.biochem.1c00696