Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Abhishek Sampath Kumar"'
Autor:
Maayan Pour, Abhishek Sampath Kumar, Naama Farag, Adriano Bolondi, Helene Kretzmer, Maria Walther, Lars Wittler, Alexander Meissner, Iftach Nachman
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103556- (2022)
Summary: The segregation of definitive endoderm (DE) from bipotent mesendoderm progenitors leads to the formation of two distinct germ layers. Dissecting DE commitment and onset has been challenging as it occurs within a narrow spatiotemporal window
Externí odkaz:
https://doaj.org/article/634ef7c38c1444a4afc99417b8a06329
Autor:
Raha Weigert, Sara Hetzel, Nina Bailly, Chuck Haggerty, Ibrahim A. Ilik, Philip Yuk Kwong Yung, Carmen Navarro, Adriano Bolondi, Abhishek Sampath Kumar, Chiara Anania, Björn Brändl, David Meierhofer, Darío G. Lupiáñez, Franz-Josef Müller, Tugce Aktas, Simon J. Elsässer, Helene Kretzmer, Zachary D. Smith, Alexander Meissner
Publikováno v:
Nature Cell Biology
DNA and Histone 3 Lysine 27 methylation typically function as repressive modifications and operate within distinct genomic compartments. In mammals, the majority of the genome is kept in a DNA methylated state, whereas the Polycomb repressive complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d193c70d47a07e4ccd7fa7838357e2d0
https://hdl.handle.net/21.11116/0000-000D-1F8D-321.11116/0000-000D-1F8F-1
https://hdl.handle.net/21.11116/0000-000D-1F8D-321.11116/0000-000D-1F8F-1
Autor:
Liat Ravid Lustig, Abhishek Sampath Kumar, Till Schwämmle, Ilona Dunkel, Gemma Noviello, Raha Weigert, Guido Pacini, René Buschow, Afrah Ghauri, Maximilian Stötzel, Lars Wittler, Alexander Meissner, Edda G. Schulz
Publikováno v:
bioRxiv
To ensure dosage compensation for X-linked genes between the sexes, one X chromosome is silenced during early embryonic development of female mammals. This process of X-chromosome inactivation (XCI) is initiated through upregulation of the RNA Xist f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c62d951e46ad30d6eef360f0366c666
https://doi.org/10.1101/2022.08.02.502458
https://doi.org/10.1101/2022.08.02.502458
Autor:
Vahid Asimi, Abhishek Sampath Kumar, Henri Niskanen, Christina Riemenschneider, Sara Hetzel, Julian Naderi, Nina Fasching, Niko Popitsch, Manyu Du, Helene Kretzmer, Zachary D. Smith, Raha Weigert, Maria Walther, Sainath Mamde, David Meierhofer, Lars Wittler, René Buschow, Bernd Timmermann, Ibrahim I. Cisse, Stefan L. Ameres, Alexander Meissner, Denes Hnisz
Publikováno v:
Nature Genetics
Most endogenous retroviruses (ERVs) in mammals are incapable of retrotransposition; therefore, why ERV derepression is associated with lethality during early development has been a mystery. Here, we report that rapid and selective degradation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aacb99499b9548036da3facfd0de18a
https://hdl.handle.net/21.11116/0000-000D-15FB-121.11116/0000-000D-15F9-3
https://hdl.handle.net/21.11116/0000-000D-15FB-121.11116/0000-000D-15F9-3
Autor:
Alexander Meissner, Henri Niskanen, Zachary J. Smith, Helene Kretzmer, Denes Hnisz, Maria Walther, Abhishek Sampath Kumar, Bernd Timmermann, Lars Wittler, Christina Riemenschneider, René Buschow, Stefan L. Ameres, David Meierhofer, Nina Fasching, Sara Hetzel, Niko Popitsch, Julian Naderi, Vahid Asimi
Endogenous retroviruses (ERVs) comprise ~10% of mammalian genomes, and ERVs are repressed by multiple cellular mechanisms including heterochromatin, DNA methylation, and methylation of their RNA transcripts 1-13. Although the vast majority of ERVs in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5291c5129fa0f10185f3e257e331903
https://doi.org/10.21203/rs.3.rs-802409/v1
https://doi.org/10.21203/rs.3.rs-802409/v1
Autor:
Alexander Meissner, Maria Walther, Maayan Pour, Lars Wittler, Iftach Nachman, Abhishek Sampath Kumar, Naama Farag
Publikováno v:
SSRN Electronic Journal.
The segregation of definitive endoderm (DE) from bi-potent mesendoderm progenitors leads to the formation of two distinct germ layers. Dissecting DE commitment and onset has been challenging as it occurs within a narrow spatio-temporal window in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9002653af013d1851fa03e771ec22f66
https://doi.org/10.2139/ssrn.3848112
https://doi.org/10.2139/ssrn.3848112
Autor:
David Meierhofer, Raha Weigert, Nina Bailly, Claudia Giesecke-Thiel, Judith Gottfreund, Chuck Haggerty, Alexander Meissner, Jörn Walter, Christina Galonska, Abhishek Sampath Kumar, Thorsten Mielke, Franz-Josef Müller, Björn Brändl, Pascal Giehr, Helene Kretzmer, Bernd Timmermann, Lars Wittler, Ferdinand von Meyenn, René Buschow, Christina Riemenschneider, Alexandra L. Mattei, Melissa B. Pappalardi, Pay Giesselmann, Michael T. McCabe
Publikováno v:
Nature Structural and Molecular Biology
Nature Structural & Molecular Biology
Nature Structural & Molecular Biology, 28 (7)
Nature Structural & Molecular Biology
Nature Structural & Molecular Biology, 28 (7)
DNA methylation plays a critical role during development, particularly in repressing retrotransposons. The mammalian methylation landscape is dependent on the combined activities of the canonical maintenance enzyme Dnmt1 and the de novo Dnmts, 3a and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e4b7af8005f3f8745559b53e7b4eaa
Autor:
Alexander Meissner, Zachary D. Smith, Sven Klages, Bernd Timmermann, Sara Hetzel, Helene Kretzmer, Shankar Mukherji, Abhishek Sampath Kumar, Stefanie Grosswendt, Lars Wittler
Publikováno v:
Nature
During ontogeny, proliferating cells become restricted in their fate through the combined action of cell-type-specific transcription factors and ubiquitous epigenetic machinery, which recognizes universally available histone residues or nucleotides i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8fd5f98c481a61fe99ee5f229ca64f
https://hdl.handle.net/21.11116/0000-0006-EAD5-221.11116/0000-0006-EAD7-0
https://hdl.handle.net/21.11116/0000-0006-EAD5-221.11116/0000-0006-EAD7-0
Autor:
Joel H.L. Tan, Chanchao Lorthongpanich, Shu Ly Lim, Diana Low, Yaju Wang, Daniel M. Messerschmidt, Heike Wollmann, Sandra Nitsch, Michelle K. Y. Seah, Abhishek Sampath Kumar, Ka Yi Ling, Ernesto Guccione
Publikováno v:
Genesdevelopment. 31(1)
Global DNA demethylation is a hallmark of embryonic epigenetic reprogramming. However, embryos engage noncanonical DNA methylation maintenance mechanisms to ensure inheritance of exceptional epigenetic germline features to the soma. Besides the parad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f18d357379631e277362f56fdfdc75a4
https://pubmed.ncbi.nlm.nih.gov/28220049
https://pubmed.ncbi.nlm.nih.gov/28220049