Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Abhishek Jamwal"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract IL-33 plays a significant role in inflammation, allergy, and host defence against parasitic helminths. The model gastrointestinal nematode Heligmosomoides polygyrus bakeri secretes the Alarmin Release Inhibitor HpARI2, an effector protein th
Externí odkaz:
https://doaj.org/article/85989ed30a0b45e5bbb0d7c6e41dd367
Autor:
Abhishek Jamwal, Cristina F Constantin, Stephan Hirschi, Sebastian Henrich, Wolfgang Bildl, Bernd Fakler, Simon J Draper, Uwe Schulte, Matthew K Higgins
Publikováno v:
eLife, Vol 12 (2023)
Basigin is an essential host receptor for invasion of Plasmodium falciparum into human erythrocytes, interacting with parasite surface protein PfRH5. PfRH5 is a leading blood-stage malaria vaccine candidate and a target of growth-inhibitory antibodie
Externí odkaz:
https://doaj.org/article/b9aa1a147c4e481b9a59a36c9d0bcded
Autor:
Robert J. Ragotte, David Pulido, Amelia M. Lias, Doris Quinkert, Daniel G. W. Alanine, Abhishek Jamwal, Hannah Davies, Adéla Nacer, Edward D. Lowe, Geoffrey W. Grime, Joseph J. Illingworth, Robert F. Donat, Elspeth F. Garman, Paul W. Bowyer, Matthew K. Higgins, Simon J. Draper
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Antibodies can have synergistic effects, but mechanisms are not well understood. Here, Ragotte et al. identify three antibodies that bind neighbouring epitopes on CyRPA, a malaria vaccine candidate, and show that lateral interactions between the anti
Externí odkaz:
https://doaj.org/article/311198660694450bbebda7b48bd4d1b2
Autor:
Francesco Vacca, Caroline Chauché, Abhishek Jamwal, Elizabeth C Hinchy, Graham Heieis, Holly Webster, Adefunke Ogunkanbi, Zala Sekne, William F Gregory, Martin Wear, Georgia Perona-Wright, Matthew K Higgins, Josquin A Nys, E Suzanne Cohen, Henry J McSorley
Publikováno v:
eLife, Vol 9 (2020)
The IL-33-ST2 pathway is an important initiator of type 2 immune responses. We previously characterised the HpARI protein secreted by the model intestinal nematode Heligmosomoides polygyrus, which binds and blocks IL-33. Here, we identify H. polygyru
Externí odkaz:
https://doaj.org/article/33d967843f4146868a42245249420393
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Inorganic pyrophosphatases (PPase) participate in energy cycling and they are essential for growth and survival of organisms. Here we report extensive structural and functional characterization of soluble PPases from the human parasites Plas
Externí odkaz:
https://doaj.org/article/4628c75d182f4e7996d49b30de5f982a
Publikováno v:
Frontiers in Molecular Biosciences, Vol 5 (2018)
Malaria parasite erythrocytic stages comprise of repeated bursts of parasites via cyclical invasion of host erythrocytes using dedicated receptor-ligand interactions. A family of erythrocyte-binding proteins from Plasmodium knowlesi (Pk) and Plasmodi
Externí odkaz:
https://doaj.org/article/a30d2b6f7e1149cabfbec8aa2b140f53
Autor:
Kriti Tyagi, Deepali Gupta, Ekta Saini, Shilpa Choudhary, Abhishek Jamwal, Mohd Shoeb Alam, Mohammad Zeeshan, Rupesh K Tyagi, Yagya D Sharma
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138691 (2015)
The monkey malaria parasite Plasmodium knowlesi also infect humans. There is a lack of information on the molecular mechanisms that take place between this simian parasite and its heterologous human host erythrocytes leading to this zoonotic disease.
Externí odkaz:
https://doaj.org/article/1efe7a03bc2d4d18b1a3d836ec284e67
Autor:
Brendan Farrell, Nawsad Alam, Melissa N. Hart, Abhishek Jamwal, Robert J. Ragotte, Hannah Walters-Morgan, Simon J. Draper, Ellen Knuepfer, Matthew K. Higgins
The symptoms of malaria occur during the blood stage of infection, when parasites invade and replicate within human erythrocytes. The five-component PfPCRCR complex, containing PfRH5, PfCyRPA, PfRIPR, PfCSS and PfPTRAMP, is essential for erythrocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f04cd68928d397a3b4e8c1a6cfdc1e2b
https://doi.org/10.1101/2023.01.30.526221
https://doi.org/10.1101/2023.01.30.526221
Autor:
Abhishek Jamwal, Cristina E. Constantin, Sebastian Henrich, Wolfgang Bildl, Bernd Fakler, Simon J. Draper, Uwe Schulte, Matthew K. Higgins
Basigin is an essential host receptor for invasion of Plasmodium falciparum into human erythrocytes, interacting with parasite surface protein PfRH5. PfRH5 is a leading blood-stage malaria vaccine candidate and a target of growth-inhibitory antibodie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f8b89590e2d59b472b29786b1428371
https://doi.org/10.1101/2022.09.23.509221
https://doi.org/10.1101/2022.09.23.509221
Autor:
Robert J, Ragotte, David, Pulido, Amelia M, Lias, Doris, Quinkert, Daniel G W, Alanine, Abhishek, Jamwal, Hannah, Davies, Adéla, Nacer, Edward D, Lowe, Geoffrey W, Grime, Joseph J, Illingworth, Robert F, Donat, Elspeth F, Garman, Paul W, Bowyer, Matthew K, Higgins, Simon J, Draper
Publikováno v:
Nature communications. 13(1)
Understanding mechanisms of antibody synergy is important for vaccine design and antibody cocktail development. Examples of synergy between antibodies are well-documented, but the mechanisms underlying these relationships often remain poorly understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7661131b60b6a79f4e393bbc0d9d5929
https://pubmed.ncbi.nlm.nih.gov/35177602
https://pubmed.ncbi.nlm.nih.gov/35177602