Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Abhishek A. Jalan"'
Autor:
Katherine Stott, Samir W. Hamaia, Birgit Leitinger, Douglas R. Walker, Jeffrey D. Hartgerink, Douglas Sammon, Paul Brear, Richard W. Farndale, Abhishek A. Jalan, Emma Hunter
Publikováno v:
Nature chemical biology
The most abundant member of the collagen protein family, collagen I (also known as type I collagen; COL1), is composed of one unique (chain B) and two similar (chain A) polypeptides that self-assemble with one amino acid offset into a heterotrimeric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292b2946fa071be9b8aeebf37041010d
http://europepmc.org/articles/PMC7100791
http://europepmc.org/articles/PMC7100791
Autor:
Richard W. Farndale, Douglas R. Walker, Jeffrey D. Hartgerink, I-Che Li, Abhishek A. Jalan, Sarah A. H. Hulgan
Publikováno v:
Organic Letters. 21:5480-5484
Stabilizing the three-dimensional structure of supramolecular materials can be accomplished through covalent capture of the assembled system. The lysine-aspartate charge pairs designed to direct the self-assembly of a collagen triple helix were subse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::487f0c537019060eb91207144b3010ce
https://doi.org/10.1021/acs.orglett.9b01771
https://doi.org/10.1021/acs.orglett.9b01771
Autor:
Abigael J. Kosgei, I-Che Li, Douglas R. Walker, Mitchell D. Miller, Jeffrey D. Hartgerink, Sarah A. H. Hulgan, Weijun Xu, George N. Phillips, Abhishek A. Jalan
Publikováno v:
Biomacromolecules. 21(9)
Collagen mimetic peptides (CMPs) self-assemble into a triple helix reproducing the most fundamental aspect of the collagen structural hierarchy. They are therefore important for both further understanding this complex family of proteins and use in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f940a062249d72969fecfc054ec35df7
https://pubmed.ncbi.nlm.nih.gov/32820897
https://pubmed.ncbi.nlm.nih.gov/32820897
Autor:
Jeffrey D. Hartgerink, Biplab Sarkar, Navindee C. Wickremasinghe, Benjamin K. Wang, Abhishek A. Jalan, Siyu Shi, Vivek A. Kumar, I-Che Li
Publikováno v:
Journal of the American Chemical Society. 137:4823-4830
Self-assembly of multidomain peptides (MDP) can be tailored to carry payloads that modulate the extracellular environment. Controlled release of growth factors, cytokines, and small-molecule drugs allows for unique control of in vitro and in vivo res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3767536e922e5ff67b23e8b51b3934
https://doi.org/10.1021/jacs.5b01549
https://doi.org/10.1021/jacs.5b01549
Autor:
Nichole L. Taylor, Marci K. Kang, Navindee C. Wickremasinghe, Siyu Shi, Jeffrey D. Hartgerink, Abhishek A. Jalan, Benjamin K. Wang, Vivek A. Kumar
Publikováno v:
ACS Nano. 9:860-868
Major limitations of current tissue regeneration approaches using artificial scaffolds are fibrous encapsulation, lack of host cellular infiltration, unwanted immune responses, surface degradation preceding biointegration, and artificial degradation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c7b225b44e26d2b007725283e2553e
https://doi.org/10.1021/nn506544b
https://doi.org/10.1021/nn506544b
Publikováno v:
Journal of the American Chemical Society. 136:7535-7538
In a canonical collagen triple helix, three peptides self-assemble into a supercoiled motif with a one-amino-acid offset between the peptide chains. Design of triple helices that contain more than one residue offset is lucrative, as it leaves the non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21812ba0855b94683ffcb3ddc357e88
https://doi.org/10.1021/ja5001246
https://doi.org/10.1021/ja5001246
Autor:
Vivek A. Kumar, Benjamin K. Wang, Jeffrey D. Hartgerink, Nichole L. Taylor, Lyahn K. Hwang, Abhishek A. Jalan
Publikováno v:
Biomacromolecules
Collagen is a major component of the extracellular matrix and plays a wide variety of important roles in blood clotting, healing, and tissue remodeling. Natural, animal derived, collagen is used in many clinical applications but concerns exist with r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da454b61f4e9744ee59a94511b7f581
http://europepmc.org/articles/PMC3993945
http://europepmc.org/articles/PMC3993945
Publikováno v:
Biomacromolecules. 14:179-185
Control over composition and register of the peptide chains in AAB-type collagen mimetic heterotrimers is critical in developing systems that show fidelity to native collagen. However, their design is challenging due to the eight competing states pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e63d3e29e805849f6482237d8a9d433
https://doi.org/10.1021/bm3015818
https://doi.org/10.1021/bm3015818
Publikováno v:
Journal of the American Chemical Society. 134:1430-1433
Design of heterotrimeric ABC collagen triple helices is challenging due to the large number of competing species that may be formed. Given the required one amino acid stagger between adjacent peptide strands in this fold, a ternary mixture of peptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8dca4b6246b006171eb0076a5dae8b7
https://doi.org/10.1021/ja209669u
https://doi.org/10.1021/ja209669u
Publikováno v:
Biomacromolecules. 16(1)
The collagen triple helix consists of three supercoiled solvent-exposed polypeptide chains, and by dry weight it is the most abundant fold in mammalian tissues. Many factors affecting the structure and stability of collagen have been determined throu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2600672973d6d19660e661daa9296968
https://pubmed.ncbi.nlm.nih.gov/25579191
https://pubmed.ncbi.nlm.nih.gov/25579191