Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Abhishek, Singharoy"'
Autor:
David Chmielewski, Eric A. Wilson, Grigore Pintilie, Peng Zhao, Muyuan Chen, Michael F. Schmid, Graham Simmons, Lance Wells, Jing Jin, Abhishek Singharoy, Wah Chiu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Coronavirus spike glycoproteins presented on the virion surface mediate receptor binding, and membrane fusion during virus entry and constitute the primary target for vaccine and drug development. How the structure dynamics of the full-lengt
Externí odkaz:
https://doaj.org/article/59f6e796a34541e8ac45dd396b94428c
Autor:
Anasuya Pal, Laura Gonzalez-Malerva, Seron Eaton, Chenxi Xu, Yining Zhang, Dustin Grief, Lydia Sakala, Lilian Nwekwo, Jia Zeng, Grant Christensen, Chitrak Gupta, Ellen Streitwieser, Abhishek Singharoy, Jin G. Park, Joshua LaBaer
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-21 (2023)
Abstract Mutations in the TP53 tumor suppressor gene occur in >80% of the triple-negative or basal-like breast cancer. To test whether neomorphic functions of specific TP53 missense mutations contribute to phenotypic heterogeneity, we characterized p
Externí odkaz:
https://doaj.org/article/a6acf0331a8a45b7b1b002a6026ce9c2
Autor:
Shamayeeta Ray, Samuel P Berry, Eric A Wilson, Casey H Zhang, Mrinal Shekhar, Abhishek Singharoy, Rachelle Gaudet
Publikováno v:
eLife, Vol 12 (2023)
Transporters of the Nramp (Natural resistance-associated macrophage protein) family import divalent transition metal ions into cells of most organisms. By supporting metal homeostasis, Nramps prevent diseases and disorders related to metal insufficie
Externí odkaz:
https://doaj.org/article/31a6a8e80ee44293aea58786ccac961d
Publikováno v:
Current Research in Structural Biology, Vol 4, Iss , Pp 68-77 (2022)
Cryo-electron microscopy (cryo-EM) has produced a number of structural models of the SARS-CoV-2 spike, already prompting biomedical outcomes. However, these reported models and their associated electrostatic potential maps represent an unknown admixt
Externí odkaz:
https://doaj.org/article/f282bd28f44747318e59a3ad51827f3f
Autor:
Ali Dashti, Ghoncheh Mashayekhi, Mrinal Shekhar, Danya Ben Hail, Salah Salah, Peter Schwander, Amedee des Georges, Abhishek Singharoy, Joachim Frank, Abbas Ourmazd
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
There is a great interest in retrieving functional pathways from cryo-EM single-particle data. Here, the authors present an approach that combines cryo-EM with advanced data-analytical methods and molecular dynamics simulations to reveal the function
Externí odkaz:
https://doaj.org/article/a9730a6e4420466a99ccf8fd2dbeaec2
Autor:
Abhishek Singharoy, Chris Chipot, Toru Ekimoto, Kano Suzuki, Mitsunori Ikeguchi, Ichiro Yamato, Takeshi Murata
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
V1-ATPase exemplifies the ubiquitous rotary motor, in which a central shaft DF complex rotates inside a hexagonally arranged catalytic A3B3 complex, powered by the energy from ATP hydrolysis. We have recently reported a number of crystal structures o
Externí odkaz:
https://doaj.org/article/e5583df1bdad4aa188574cf64909c389
Publikováno v:
Biochemistry
Cytochrome c(2) (cyt. c(2)) is a major element in electron transfer between redox proteins in bioenergetic membranes. While the interaction between cyt. c(2) and anionic lipids abundant in bioenergetic membranes has been reported, their effect on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daeed8a291bbf8a57343e24381c68c98
https://doi.org/10.1021/acs.biochem.1c00696
https://doi.org/10.1021/acs.biochem.1c00696
Autor:
David Chmielewski, Eric Wilson, Grigore Pintilie, Peng Zhao, Muyuan Chen, Michael Schmid, Graham Simmons, Lance Wells, Jing Jin, Abhishek Singharoy, Wah Chiu
Coronavirus spike glycoproteins presented on the virion surface mediate receptor binding, and membrane fusion during virus entry and constitute the primary target for vaccine and drug development. How the structure dynamics of the full-length spikes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ea025121afa6897b20756720a3df988
https://doi.org/10.21203/rs.3.rs-2553619/v1
https://doi.org/10.21203/rs.3.rs-2553619/v1
Publikováno v:
Cancer Research. 83:5376-5376
The ability to accurately identify peptide ligands for a given major histocompatibility complex class I (MHC-I) molecule has immense value for targeted anticancer therapeutics. However, the highly polymorphic nature of the MHC-I protein makes univers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65f832dd62c451978b6494330a636320
https://doi.org/10.1158/1538-7445.am2023-5376
https://doi.org/10.1158/1538-7445.am2023-5376