Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Abhisek Bhattacharya"'
Autor:
François Van Laethem, Abhisek Bhattacharya, Marco Craveiro, Jinghua Lu, Peter D. Sun, Alfred Singer
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Understanding the generation of an MHC-restricted T cell repertoire is the cornerstone of modern T cell immunology. The unique ability of αβT cells to only recognize peptide antigens presented by MHC molecules but not conformational antigens is ref
Externí odkaz:
https://doaj.org/article/76e87e0eec1242be99fc58fb598e83f1
Autor:
Jinghua Lu, François Van Laethem, Abhisek Bhattacharya, Marco Craveiro, Ingrid Saba, Jonathan Chu, Nicholas C. Love, Anastasia Tikhonova, Sergei Radaev, Xiaoping Sun, Annette Ko, Tomer Arnon, Eric Shifrut, Nir Friedman, Nan-Ping Weng, Alfred Singer, Peter D. Sun
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
For T cells, functional antigen receptors are selected in the thymus from a pre-selection repertoire by interaction with self MHCs. Here the authors show that specific, non-germline coded features located in the complementarity determining region 3 o
Externí odkaz:
https://doaj.org/article/2135b8948a994dbda344f75d21b684fb
Autor:
François Van Laethem, Ingrid Saba, Jinghua Lu, Abhisek Bhattacharya, Xuguang Tai, Terry I. Guinter, Britta Engelhardt, Amala Alag, Mirelle Rojano, Jennifer M. Ashe, Ken-ichi Hanada, James C. Yang, Peter D. Sun, Alfred Singer
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
MHC-independent αβTCRs (TCRs) recognize conformational epitopes on native self-proteins and arise in mice lacking both MHC and CD4/CD8 coreceptor proteins. Although naturally generated in the thymus, these TCRs resemble re-engineered therapeutic ch
Externí odkaz:
https://doaj.org/article/8782eccbbb154dcb86bc5b3f712336d7
Autor:
Abhisek Bhattacharya, Qin Wei, Jin Na Shin, Elmoataz Abdel Fattah, Diana L. Bonilla, Qian Xiang, N. Tony Eissa
Publikováno v:
Cell Reports, Vol 12, Iss 11, Pp 1731-1739 (2015)
Autophagy, an intracellular degradation and energy recycling mechanism, is emerging as an important regulator of immune responses. However, the role of autophagy in regulating neutrophil functions is not known. We investigated neutrophil biology usin
Externí odkaz:
https://doaj.org/article/59c3ed9d92ff431aaeffa0e32cc0a222
Autor:
Lang Rao, Yi Xu, Lucas Charles Reineke, Abhisek Bhattacharya, Alexey Tyryshkin, Jin Na Shin, N. Tony Eissa
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 12, p 4318 (2020)
Alpha one antitrypsin (α1AT), a serine proteinase inhibitor primarily produced by the liver, protects pulmonary tissue from neutrophil elastase digestion. Mutations of the SERPINA1 gene results in a misfolded α1AT protein which aggregates inside he
Externí odkaz:
https://doaj.org/article/12d34421b508451da5850de14fbf8543
Lymphangioleiomyomatosis (LAM) is a progressive cystic lung disease affecting some women with tuberous sclerosis complex (TSC). Sporadic LAM can develop in women without TSC, owing to somatic mutations in the TSC2 gene. Accumulating evidence supports
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79e3aaf6c65a33a62672cd145398bddb
https://doi.org/10.1158/0008-5472.c.6505995
https://doi.org/10.1158/0008-5472.c.6505995
Increased phospho-Src in LAM lungs (Figure S1); Enhanced activation of Src, STAT3 and Snail in human LAM cells (Figure S2); mTOR activation in TSC2-deficient cells (Figure S3); Src kinase is activated in TSC2-deficient cells (Figure S4); Knockdown of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab71a542f2b66916c1421fb834270448
https://doi.org/10.1158/0008-5472.22402134.v1
https://doi.org/10.1158/0008-5472.22402134.v1
Autor:
Miho Shinzawa, E. Ashley Moseman, Selamawit Gossa, Yasuko Mano, Abhisek Bhattacharya, Terry Guinter, Amala Alag, Xiongfong Chen, Maggie Cam, Dorian B. McGavern, Batu Erman, Alfred Singer
Publikováno v:
Nature immunology. 23(5)
T cell specificity and function are linked during development, as MHC-II-specific TCR signals generate CD4 helper T cells and MHC-I-specific TCR signals generate CD8 cytotoxic T cells, but the basis remains uncertain. We now report that switching cor
Autor:
Terry I. Guinter, Mirelle Rojano, Britta Engelhardt, Ingrid Saba, James Chih-Hsin Yang, Abhisek Bhattacharya, Jinghua Lu, Ken-ichi Hanada, Amala Alag, Alfred Singer, François Van Laethem, Peter D. Sun, Jennifer M. Ashe, Xuguang Tai
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Van Laethem, François; Saba, Ingrid; Lu, Jinghua; Bhattacharya, Abhisek; Tai, Xuguang; Guinter, Terry I; Engelhardt, Britta; Alag, Amala; Rojano, Mirelle; Ashe, Jennifer M; Hanada, Ken-Ichi; Yang, James C; Sun, Peter D; Singer, Alfred (2020). Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus. Frontiers in immunology, 11, p. 1216. Frontiers Research Foundation 10.3389/fimmu.2020.01216
Frontiers in Immunology, Vol 11 (2020)
Van Laethem, François; Saba, Ingrid; Lu, Jinghua; Bhattacharya, Abhisek; Tai, Xuguang; Guinter, Terry I; Engelhardt, Britta; Alag, Amala; Rojano, Mirelle; Ashe, Jennifer M; Hanada, Ken-Ichi; Yang, James C; Sun, Peter D; Singer, Alfred (2020). Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus. Frontiers in immunology, 11, p. 1216. Frontiers Research Foundation 10.3389/fimmu.2020.01216
MHC-independent αβTCRs (TCRs) recognize conformational epitopes on native self-proteins and arise in mice lacking both MHC and CD4/CD8 coreceptor proteins. Although naturally generated in the thymus, these TCRs resemble re-engineered therapeutic ch
Autor:
Jin Na Shin, N Tony Eissa, Abhisek Bhattacharya, Alexey Tyryshkin, Lucas C. Reineke, Yi Xu, Lang Rao
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 4318, p 4318 (2020)
Volume 21
Issue 12
International Journal of Molecular Sciences, Vol 21, Iss 4318, p 4318 (2020)
Volume 21
Issue 12
Alpha one antitrypsin (&alpha
1AT), a serine proteinase inhibitor primarily produced by the liver, protects pulmonary tissue from neutrophil elastase digestion. Mutations of the SERPINA1 gene results in a misfolded &alpha
1AT protein which
1AT), a serine proteinase inhibitor primarily produced by the liver, protects pulmonary tissue from neutrophil elastase digestion. Mutations of the SERPINA1 gene results in a misfolded &alpha
1AT protein which