Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Abhinav Luthra"'
Autor:
Alan C. Cheng, Elizabeth M. Doherty, Sheree Johnstone, Erin F. DiMauro, Jennifer Dao, Abhinav Luthra, Jay Ye, Jie Tang, Thomas Nixey, Xiaoshan Min, Philip Tagari, Les P. Miranda, Zhulun Wang
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract Small molecules and antibodies each have advantages and limitations as therapeutics. Here, we present for the first time to our knowledge, the structure-guided design of “chemibodies” as small molecule-antibody hybrids that offer dual re
Externí odkaz:
https://doaj.org/article/03c054e59aee48aa9fd15ab0e960b901
Autor:
Chris Yallop, Ziv Sandalon, Sarwat Cheema, Stephen Whitney, Abhinav Luthra, Menzo J. E. Havenga, Wilfried A.M. Bakker, James C. Richardson
Publikováno v:
Biologicals
The HIV-1 derived gp145 protein is being investigated by research groups as preclinical studies have shown high promise for this protein as a vaccine against HIV. However, one of the main challenges with manufacturing this promising protein has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0a747dad8ae15f3d01a6813d9760cd
https://doi.org/10.1016/j.biologicals.2021.07.004
https://doi.org/10.1016/j.biologicals.2021.07.004
Autor:
Tao Jing, Sarwat Cheema, Menzo J. E. Havenga, Nathalie Veith, Femke Hoeksema, Wilfried A.M. Bakker, Yi Zhao, Remco A. Spanjaard, Lars Kober, Yiding Wang, Abhinav Luthra, Chris Yallop
Publikováno v:
Protein Expression and Purification. 186:105920
Many proteins produced in CHO cells need evaluation for their clinical and commercial potential. Traditional methods based on stable clone generation are slow and unsuitable for screening larger numbers of proteins, while transient expression technol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93a435642ba951b3564d4cd650a2061a
https://doi.org/10.1016/j.pep.2021.105920
https://doi.org/10.1016/j.pep.2021.105920
Publikováno v:
Journal of the American Chemical Society
CYP19A1, or aromatase, a cytochrome P450 responsible for estrogen biosynthesis in humans, is an important therapeutic target for the treatment of breast cancer. There is still controversy surrounding the identity of reaction intermediate that catalyz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f7a4a71b6b26dd170c5e40cdcd0cc2
https://doi.org/10.1021/ja500054c
https://doi.org/10.1021/ja500054c
Autor:
Jennifer Dao, Erin F. DiMauro, Elizabeth M. Doherty, Jie Tang, Philip Tagari, Alan C. Cheng, Jing Ye, Les P. Miranda, Xiaoshan Min, Thomas Nixey, Zhulun Wang, Abhinav Luthra, Sheree Johnstone
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 75:a220-a220
Small molecules and antibodies each have advantages and limitations as therapeutics. Here, we present for the first time to our knowledge, the structure-guided design of "chemibodies" as small molecule-antibody hybrids that offer dual recognition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac612407bf2375fd9f4c06016e1adc3e
https://doi.org/10.1107/s0108767319097836
https://doi.org/10.1107/s0108767319097836
Publikováno v:
Analytical Chemistry. 83:5394-5399
Temperature derivative spectroscopy (TDS), a type of relaxation spectroscopy, is a powerful tool to study protein dynamics (Berendzen, J.; Braunstein, D. Proc. Natl. Acad. Sci. U. S. A. 1990, 87, 1). We developed the version of temperature derivative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40119b6282a5f3467fcd521eb7733c8
https://doi.org/10.1021/ac2009349
https://doi.org/10.1021/ac2009349
Autor:
Utpal Bora, Angad Singh, Abhinav Luthra, Naresh Kasoju, Shahin S. Ali, Hallihosur Sharanabasava, Abhishek Sahu
Publikováno v:
Food Research International. 41:1-15
Currently there has been an increased interest globally to identify antioxidant compounds that are pharmacologically potent and have low or no side effects for use in preventive medicine and the food industry. As plants produce significant amount of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fabf41dd1cc29c63adaa34020c523237
https://doi.org/10.1016/j.foodres.2007.10.001
https://doi.org/10.1016/j.foodres.2007.10.001
Publikováno v:
Journal of Biosciences. 32:883-889
Inter-residue potentials are extensively used in the design and evaluation of protein structures. However,dealing with all (20 x 20) interactions becomes computationally difficult in extensive investigations. Hence, it is desirable to reduce the alph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf570f37b246b25c3ce18e75ed425198
https://doi.org/10.1007/s12038-007-0088-y
https://doi.org/10.1007/s12038-007-0088-y
Publikováno v:
Methods in Molecular Biology ISBN: 9781627033206
Cytochromes P450 from eukaryotes and their native redox partners cytochrome P450 reductases both belong to the class of monotopic membrane proteins containing one transmembrane anchor. Incorporation into the lipid bilayer significantly affects their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d097e26a097a4a46ae5c6a48b9b8d1f6
https://doi.org/10.1007/978-1-62703-321-3_10
https://doi.org/10.1007/978-1-62703-321-3_10
Publikováno v:
Archives of biochemistry and biophysics. 507(1)
Cytochromes P450 constitute a broad class of heme monooxygenase enzymes with more than 11,500 isozymes which have been identified in organisms from all biological kingdoms [1]. These enzymes are responsible for catalyzing dozens chemical oxidative tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f14d771694e89761fa7dae9c3a782dd
https://pubmed.ncbi.nlm.nih.gov/21167809
https://pubmed.ncbi.nlm.nih.gov/21167809