Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Abhinav, Diwan"'
Autor:
Abhinav Diwan
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 14 (2023)
Hypertrophic cardiomyopathy and pathological cardiac hypertrophy are characterized by mitochondrial structural and functional abnormalities. In this issue of the JCI, Zhuang et al. discovered 1-deoxynojirimycin (DNJ) through a screen of mitochondrial
Externí odkaz:
https://doaj.org/article/7435de1151cd441f9dd684579abfabbc
Autor:
Ping Yan, Ki-Wook Kim, Qingli Xiao, Xiucui Ma, Leah R. Czerniewski, Haiyan Liu, David R. Rawnsley, Yan Yan, Gwendalyn J. Randolph, Slava Epelman, Jin-Moo Lee, Abhinav Diwan
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 11 (2022)
Microglia, the parenchymal tissue macrophages in the brain, surround amyloid plaques in brains of individuals with Alzheimer’s disease (AD) but are ineffective at clearing amyloid to mitigate disease progression. Recent studies in mice indicate tha
Externí odkaz:
https://doaj.org/article/27704bd3066749ef9a3e3a8ea5e14f2b
Autor:
S Kusumvalli, Abhinav Diwan, Shiraz Pasha, Madhuri R Devale, Chava Deepak Chowdhary, Priyanki Saikia
Publikováno v:
Indian Journal of Dental Research, Vol 30, Iss 2, Pp 191-195 (2019)
Background: The advancement in the dentin regeneration aiming at the preservation of pulpal vitality has challenged the traditional concept of substituting diseased tooth with inert materials. Clinical studies, demonstrating preservation of pulpal vi
Externí odkaz:
https://doaj.org/article/de8799800e784197807e68cb953339b8
Autor:
Zhen Guo, Carla Valenzuela Ripoll, Antonino Picataggi, David R. Rawnsley, Mualla Ozcan, Julio A. Chirinos, Ezhilarasi Chendamarai, Amanda Girardi, Terrence Riehl, Hosannah Evie, Ahmed Diab, Attila Kovacs, Krzysztof Hyrc, Xiucui Ma, Aarti Asnani, Swapnil V. Shewale, Marielle Scherrer-Crosbie, Lauren Ashley Cowart, John S. Parks, Lei Zhao, David Gordon, Francisco Ramirez-Valle, Kenneth B. Margulies, Thomas P. Cappola, Ankit A. Desai, Lauren N. Pederson, Carmen Bergom, Nathan O. Stitziel, Michael P. Rettig, John F. DiPersio, Stefan Hajny, Christina Christoffersen, Abhinav Diwan, Ali Javaheri
Publikováno v:
JACC Basic Transl Sci
Guo, Z, Valenzuela Ripoll, C, Picataggi, A, Rawnsley, D R, Ozcan, M, Chirinos, J A, Chendamarai, E, Girardi, A, Riehl, T, Evie, H, Diab, A, Kovacs, A, Hyrc, K, Ma, X, Asnani, A, Shewale, S V, Scherrer-Crosbie, M, Cowart, L A, Parks, J S, Zhao, L, Gordon, D, Ramirez-Valle, F, Margulies, K B, Cappola, T P, Desai, A A, Pedersen, L N, Bergom, C, Stitziel, N O, Rettig, M P, DiPersio, J F, Hajny, S, Christoffersen, C, Diwan, A & Javaheri, A 2023, ' Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury ', JACC: Basic to Translational Science, vol. 8, no. 3, pp. 340-355 . https://doi.org/10.1016/j.jacbts.2022.09.010
Guo, Z, Valenzuela Ripoll, C, Picataggi, A, Rawnsley, D R, Ozcan, M, Chirinos, J A, Chendamarai, E, Girardi, A, Riehl, T, Evie, H, Diab, A, Kovacs, A, Hyrc, K, Ma, X, Asnani, A, Shewale, S V, Scherrer-Crosbie, M, Cowart, L A, Parks, J S, Zhao, L, Gordon, D, Ramirez-Valle, F, Margulies, K B, Cappola, T P, Desai, A A, Pedersen, L N, Bergom, C, Stitziel, N O, Rettig, M P, DiPersio, J F, Hajny, S, Christoffersen, C, Diwan, A & Javaheri, A 2023, ' Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury ', JACC: Basic to Translational Science, vol. 8, no. 3, pp. 340-355 . https://doi.org/10.1016/j.jacbts.2022.09.010
ObjectivesDetermine the role of apolipoprotein M (ApoM) in anthracycline (Dox) cardiotoxicity.BackgroundApoM binds the cardioprotective sphingolipid sphingosine-1-phosphate (S1P). Circulating ApoM is inversely associated with mortality in human heart
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Homeostasis in vertebrate systems is contingent on normal cardiac function. This, in turn, depends on intricate protein-based cellular machinery, both for contractile function, as well as, durability of cardiac myocytes. The cardiac small heat shock
Externí odkaz:
https://doaj.org/article/cca97ab1507a49dfad0b19286efb13fd
Autor:
David R. Rawnsley, Abhinav Diwan
Publikováno v:
EBioMedicine, Vol 56, Iss , Pp 102824- (2020)
Obesity is a global epidemic contributing to the rising prevalence of multiple disorders including metabolic syndrome, diabetes, fatty liver disease, cardiovascular and cerebrovascular disease, Alzheimer's disease and certain cancers. A renewed sense
Externí odkaz:
https://doaj.org/article/4004c46adaae4104a3bf297c742834af
Autor:
Rimpy Dhingra, Inna Rabinovich-Nikitin, Sonny Rothman, Matthew Guberman, Hongying Gang, Victoria Margulets, Davinder S. Jassal, Keshav Narayan Alagarsamy, Sanjiv Dhingra, Carla Valenzuela Ripoll, Filio Billia, Abhinav Diwan, Ali Javaheri, Lorrie A. Kirshenbaum
Publikováno v:
Circulation. 146:934-954
Background: Cytokines such as tumor necrosis factor-α (TNFα) have been implicated in cardiac dysfunction and toxicity associated with doxorubicin (DOX). Although TNFα can elicit different cellular responses, including survival or death, the mechan
Autor:
Qiuyun Pan, Ping Yan, Alexander B. Kim, Qingli Xiao, Gaurav Pandey, Hans Haecker, Slava Epelman, Abhinav Diwan, Jin-Moo Lee, Carl J. DeSelm
Substantial evidence suggests a role for immunotherapy in treating Alzheimer’s disease (AD). Several monoclonal antibodies targeting aggregated forms of beta amyloid (Aβ), have been shown to reduce amyloid plaques and in some cases, mitigate cogni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e351c52793971f9fafa24003615375c
https://doi.org/10.1101/2023.04.28.538637
https://doi.org/10.1101/2023.04.28.538637
Autor:
Ismail Sergin, Trent D. Evans, Xiangyu Zhang, Somashubhra Bhattacharya, Carl J. Stokes, Eric Song, Sahl Ali, Babak Dehestani, Karyn B. Holloway, Paul S. Micevych, Ali Javaheri, Jan R. Crowley, Andrea Ballabio, Joel D. Schilling, Slava Epelman, Conrad C. Weihl, Abhinav Diwan, Daping Fan, Mohamed A. Zayed, Babak Razani
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-20 (2017)
Dysfunction of autophagy in plaque macrophages aggravates atherosclerosis. Here the authors show that induction of macrophage autophagy–lysosomal biogenesis either genetically by overexpression of the master transcriptional regulator of this proces
Externí odkaz:
https://doaj.org/article/2386c202410647229c348496bc117d5b
Autor:
John T Murphy, Haiyan Liu, Xiucui Ma, Alex Shaver, Brian M Egan, Clara Oh, Alexander Boyko, Travis Mazer, Samuel Ang, Rohan Khopkar, Ali Javaheri, Sandeep Kumar, Xuntian Jiang, Daniel Ory, Kartik Mani, Scot J Matkovich, Kerry Kornfeld, Abhinav Diwan
Publikováno v:
PLoS Biology, Vol 17, Iss 5, p e3000245 (2019)
Lysosomes are ubiquitous acidified organelles that degrade intracellular and extracellular material trafficked via multiple pathways. Lysosomes also sense cellular nutrient levels to regulate target of rapamycin (TOR) kinase, a signaling enzyme that
Externí odkaz:
https://doaj.org/article/c52633b4ef644f0ebfbbc8300d13c9c3