Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Abhimanyu Paraskar"'
Autor:
Dimitri Y. Chirgadze, R. A. Mashelkar, Ermanno Gherardi, Rania Harfouche, Rituparna Sinha Roy, Arthur Rowe, Pooja R. Vasudevan, Shivani Soni, Dirk M. Hentschel, Abhimanyu Paraskar, Tom L. Blundell, Shiladitya Sengupta, Hugo de Jonge, Oliver Holmes
Publikováno v:
Proceedings of the National Academy of Sciences; Vol 107
Therapeutic angiogenesis is an emerging paradigm for the management of ischemic pathologies. Proangiogenic Therapy is limited, however, by the current inability to deliver angiogenic factors in a sustained manner at the site of pathology. In this stu
Autor:
Kenneth T. Chin, Innocent Jayawardene, Bhaskar Roy, Shiladitya Sengupta, Katherine W. Muto, Shivani Soni, Raghunath Anant Mashelkar, Chitra Amarasiriwardena, Michael S. Oh, Yamicia D. Connor, Ashish Kulkarni, Daniela M. Dinulescu, Ambarish Pandey, Sasmit Sarangi, Joseph V. Bonventre, Poulomi Sengupta, Jawahar Kopparam, Abhimanyu Paraskar, Sudipta Basu, Nicola Lupoli, Venkata S. Sabbisetti
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 109(28)
Nanoscale drug delivery vehicles have been harnessed extensively as carriers for cancer chemotherapeutics. However, traditional pharmaceutical approaches for nanoformulation have been a challenge with molecules that exhibit incompatible physicochemic
Publikováno v:
Nanotechnology. 23(7)
Nanoscale drug delivery vehicles have been extensively studied as carriers for cancer chemotherapeutics. However, the formulation of platinum chemotherapeutics in nanoparticles has been a challenge arising from their physicochemical properties. There
Autor:
Shivani Soni, Abhimanyu Paraskar, Sudipta Basu, Shiladitya Sengupta, Rituparna Sinha Roy, Nicola Lupoli, Shyam Srivats, Chitra Amarasiriwardena
The use of cisplatin, a first line chemotherapy for most cancers, is dose-limited due to nephrotoxicity. While this toxicity can be addressed through nanotechnology, previous attempts at engineering cisplatin nanoparticles have been limited by the im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be6f30a2578333c0cb2c55f52333af6
https://europepmc.org/articles/PMC3158969/
https://europepmc.org/articles/PMC3158969/
Autor:
Abhimanyu Paraskar
We demonstrate that the rational engineering of a polymer inspired by the bioactivation of cisplatin and oxaliplatin enables the engineering of a unique nanoplatinates, which improves antitumor efficacy of cisplatin by capitalizing on the inherent pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b72ba811d3247004a6c52dd62777476f
https://doi.org/10.21236/ada551414
https://doi.org/10.21236/ada551414
Autor:
Shiladitya Sengupta, Padmaparna Chaudhuri, Shivani Soni, Kenneth T. Chin, Basar Bilgicer, Katherine W. Muto, Michael W. Handlogten, Nathan J. Alves, Abhimanyu Paraskar, Julia Berkowitz, R. A. Mashelkar, Daniela M. Dinulescu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 107(28)
Cisplatin is a first line chemotherapy for most types of cancer. However, its use is dose-limited due to severe nephrotoxicity. Here we report the rational engineering of a novel nanoplatinate inspired by the mechanisms underlying cisplatin bioactiva
Autor:
Shivani Soni, Shiladitya Sengupta, Pooja R. Vasudevan, Abhimanyu Paraskar, Rania Harfouche, Rituparna Sinha Roy
Publikováno v:
The FASEB Journal. 24
Therapeutic angiogenesis is an emerging concept that can potentially be harnessed for management of ischemic pathologies. Hepatocyte growth factor/scatter factor (HGF/SF) promotes angiogenesis but ...
Publikováno v:
ACS nano. 3(9)
In the present study, we report the novel application of polyhydroxylated fullerenes (fullerenols) in cancer drug delivery. The facile synthetic procedure for generating multiple hydroxyl groups on the fullerene cage offers scope for high drug loadin
Publikováno v:
Cancer Research. 70:3520-3520
Cis-diamminedichloroplatinum (II) (CDDP) is a platinum based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas, lymphomas, and germ cell tumors. There are two major concerns of cisplatin based chemotherapy:
Publikováno v:
Cancer Research. 70:5488-5488
The use of nanovectors holds the potential to revolutionize cancer chemotherapy by specifically targeting tumor. A number of polymeric nanovectors are currently in development or in clinics, and are dramatically altering the pharmacodynamics and phar