Zobrazeno 1 - 10
of 281
pro vyhledávání: '"Abhimanyu Garg"'
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109517- (2024)
Summary: Both humans and mice with congenital generalized lipodystrophy due to AGPAT2 deficiency develop diabetes mellitus, insulin resistance, and hepatic steatosis, which have been attributed to the near total loss of adipose tissue (AT). Here, we
Externí odkaz:
https://doaj.org/article/3b46cd7f3a354f9a9e35118f7af216af
Autor:
Anil K. Agarwal, Katie Tunison, Goncalo Vale, Jeffrey G. McDonald, Xilong Li, Jay D. Horton, Abhimanyu Garg
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108653- (2024)
Summary: AGPAT2, a critical enzyme involved in the biosynthesis of phospholipids and triacylglycerol (TAG), is highly expressed in adipose tissue (AT). Whether overexpression of AGPAT2 in AT will result in increased TAG synthesis (obesity) and its me
Externí odkaz:
https://doaj.org/article/380c5aacd5c3490d8b8b1f8961965494
Autor:
Anil K. Agarwal, Katie Tunison, Goncalo Vale, Jeffrey G. McDonald, Xilong Li, Philipp E. Scherer, Jay D. Horton, Abhimanyu Garg
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107806- (2023)
Summary: Genetic loss of Agpat2 in humans and mice results in congenital generalized lipodystrophy with near-total loss of adipose tissue and predisposition to develop insulin resistance, diabetes mellitus, hepatic steatosis, and hypertriglyceridemia
Externí odkaz:
https://doaj.org/article/cbfdbaa2bfeb492e96fa08ae536cb1d7
Autor:
Abhimanyu Garg, Wee-Teik Keng, Zhenkang Chen, Adwait Amod Sathe, Chao Xing, Pavithira Devi Kailasam, Yanqiu Shao, Nicholas P. Lesner, Claire B. Llamas, Anil K. Agarwal, Prashant Mishra
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 23 (2022)
Multiple genetic loci have been reported for progeroid syndromes. However, the molecular defects in some extremely rare forms of progeria have yet to be elucidated. Here, we report a 21-year-old man of Chinese ancestry who has an autosomal recessive
Externí odkaz:
https://doaj.org/article/486f4ee4357c45cca2ea1e35adcccde2
Publikováno v:
Journal of Family Medicine and Primary Care, Vol 11, Iss 10, Pp 6590-6592 (2022)
Pulmonary tuberculosis has diverse clinical presentations. Cysts in the lung can arise due to large number of causes out of which tuberculosis is very rare. We report two immunocompetent cases of pulmonary tuberculosis who presented with multiple cys
Externí odkaz:
https://doaj.org/article/ecfb8745762e4b3590e54cb322d0f15e
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 12, Pp 2057-2073 (2019)
Loss of dysferlin (DYSF) protein in humans results in limb-girdle muscular dystrophy 2B, characterized by progressive loss of muscles in the distal limbs with impaired locomotion. The DYSF-null (Bla/J) mouse develops severe steatotic muscles upon agi
Externí odkaz:
https://doaj.org/article/01824c417299449abe889821f573f51a
Autor:
Amit Saha MD, Abhimanyu Garg MD
Publikováno v:
Journal of Investigative Medicine High Impact Case Reports, Vol 9 (2021)
Statins are recommended for first-line management of elevated cholesterol in the primary and secondary prevention of atherosclerotic cardiovascular disease. Statins may occasionally be associated with mild transaminase elevations but can also result
Externí odkaz:
https://doaj.org/article/8820e37feb2d4c22a724ebdabe724285
Autor:
Kelly M. Cautivo, Carlos O. Lizama, Pablo J. Tapia, Anil K. Agarwal, Abhimanyu Garg, Jay D. Horton, Víctor A. Cortés
Publikováno v:
Molecular Metabolism, Vol 5, Iss 7, Pp 491-505 (2016)
Objective: Characterize the cellular and molecular events responsible for lipodystrophy in AGPAT2 deficient mice. Methods: Adipose tissue and differentiated MEF were assessed using light and electron microscopy, followed by protein (immunoblots) and
Externí odkaz:
https://doaj.org/article/9036d9b500c24e3b97bd10245a6e2e3c
Autor:
Anil K. Agarwal, Katie Tunison, Jasbir S. Dalal, Chi-Liang Eric Yen, Robert V. Jr.Farese, Jay D. Horton, Abhimanyu Garg
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 4, Pp 616-630 (2016)
Reducing triacylglycerol (TAG) in the liver continues to pose a challenge in states of nonalcoholic hepatic steatosis. Monoacylglycerol O-acyltransferase (MOGAT) enzymes convert monoacylglycerol (MAG) to diacylglycerol, a precursor for TAG synthesis,
Externí odkaz:
https://doaj.org/article/586f580d3361487a93cbfa07730bf26c
Autor:
Víctor A. Cortés, Kelly M. Cautivo, Shunxing Rong, Abhimanyu Garg, Jay D. Horton, Anil K. Agarwal
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 2, Pp 276-288 (2014)
Leptin is essential for energy homeostasis and regulation of food intake. Patients with congenital generalized lipodystrophy (CGL) due to mutations in 1-acylglycerol-3-phosphate-O-acyltransferase 2 (AGPAT2) and the CGL murine model (Agpat2−/− mic
Externí odkaz:
https://doaj.org/article/01deecd765a8409e813e92cd41137ed9