Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Abhilash K. Ravindranath"'
CD44 promotes multi-drug resistance by protecting P-glycoprotein from FBXO21-mediated ubiquitination
Autor:
Roman P. Wernyj, Abhilash K. Ravindranath, Lorna Rodriguez-Rodriguez, Muthu N. Kumaran, Swayamjot Kaur, Elaine T. Lim, Rigel Chan, Karl E. Miletti-González, Kiran Madura
Publikováno v:
Oncotarget
Here we demonstrate that a ubiquitin E3-ligase, FBXO21, targets the multidrug resistance transporter, ABCB1, also known as P-glycoprotein (P-gp), for proteasomal degradation. We also show that the Ser291-phosphorylated form of the multifunctional pro
Autor:
Marina Chekmareva, Roman P. Wernyj, Kathleen W. Scotto, Muthu N. Kumaran, Gregory D. Miles, Elaine T. Lim, Karl E. Miletti-González, Michael Reiss, Kyle A. Murphy, Elisa V. Bandera, Swayamjot Kaur, Rigel Chan, Debra S. Heller, David J. Foran, Wenjin Chen, Abhilash K. Ravindranath, Lorna Rodriguez-Rodriguez
Publikováno v:
Journal of Biological Chemistry. 287:18995-19007
CD44 is a multifunctional cell receptor that conveys a cancer phenotype, regulates macrophage inflammatory gene expression and vascular gene activation in proatherogenic environments, and is also a marker of many cancer stem cells. CD44 undergoes seq
Autor:
Abhilash K. Ravindranath, Lorna Rodriguez-Rodriguez, Neelakandan Muthukumaran, Karl E. Miletti-González
Publikováno v:
Molecular Cancer Research. 4:511-520
Chronic inflammation is implicated in the pathophysiology of ovarian cancer. Tumor necrosis factor-α (TNF-α), a major inflammatory cytokine, is abundant in the ovarian cancer microenvironment. TNF-α modulates the expression of CD44 in normal T lym
Autor:
Ed Croze, William A. Clark, Weigang Tang, Serge Y. Fuchs, K.G. Suresh Kumar, Abhilash K. Ravindranath
Publikováno v:
The EMBO journal. 22(20)
Down-regulation of activated signaling receptors in response to their ligands plays a key role in restricting the extent and duration of the signaling. Mechanisms underlying down-regulation of the type I interferon receptor consisting of IFNAR1 and I
Autor:
Abhilash K. Ravindranath, Lorna Rodriguez-Rodriguez, Kyle A. Murphy, Swayamjot Kaur, Karl E. Miletti
Publikováno v:
Cancer Research. 74:758-758
The main causes of treatment failure and mortality in cancer are metastases and the development of drug resistance. CD44 and P-gp are two membrane proteins well-known determinants of metastases and drug resistance respectively. We and others have sho
Publikováno v:
Cancer Research. 72:4226-4226
Drug resistance and metastases are major causes of treatment failure in cancer. These two important but not clearly related aspects in the biology of cancer have been extensively studied, but not until recently has there been evidence that these phen
Autor:
Christine L. Hostetter, Karl E. Miletti-González, Neelakandan Muthukumaran, Judith C. Keen, Abhilash K. Ravindranath, Lorna Rodriguez-Rodriguez
Publikováno v:
Cancer Research. 71:3078-3078
CD44, a major hyaluronic acid (HA) receptor, is involved in cell migration, metastasis and tumor progression. While in normal ovarian epithelium CD44 is not expressed, ovarian carcinoma cells express multiple CD44 isoforms as the tumor progresses and