Výsledky vyhledávání - "Abhilash Gadi"

Akademický článek

Autor: Tea Shavlakadze, Kun Xiong, Shawn Mishra, Corissa McEwen, Abhilash Gadi, Matthew Wakai, Hunter Salmon, Michael J. Stec, Nicole Negron, Min Ni, Yi Wei, Gurinder S. Atwal, Yu Bai, David J. Glass

Publikováno v: Skeletal Muscle, Vol 13, Iss 1, Pp 1-15 (2023)

Abstract Background As a result of aging, skeletal muscle undergoes atrophy and a decrease in function. This age-related skeletal muscle weakness is known as “sarcopenia”. Sarcopenia is part of the frailty observed in humans. In order to discover

Externí odkaz: https://doaj.org/article/a43926fa120c4d5db9e644d5c5986045

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Supplementary Figures 1-4 from Inflammatory Breast Cancer Promotes Development of M2 Tumor-Associated Macrophages and Cancer Mesenchymal Cells through a Complex Chemokine Network

Autor: Robert J. Schneider, Hua Zhong, Shah Giashuddin, Rezina Arju, Beth Walters, Viviana Volta, Abhilash Gadi, Amanda Valeta-Magara

FS1: Four panels (A-D) demonstrating that SUM190 cells are enriched in cancer stem-like cells, shown by immunoblot analysis, cell flow cytometry and by increased cell invasion. FS2: Three panels (A-C) showing that co-culture of IBC cells with monocyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53fe3b3aa0732602bfe9aae2caa06b95
https://doi.org/10.1158/0008-5472.22418931

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Supplementary Tables from Inflammatory Breast Cancer Promotes Development of M2 Tumor-Associated Macrophages and Cancer Mesenchymal Cells through a Complex Chemokine Network

Autor: Robert J. Schneider, Hua Zhong, Shah Giashuddin, Rezina Arju, Beth Walters, Viviana Volta, Abhilash Gadi, Amanda Valeta-Magara

TS1 describes the characteristics of the cell lines used in this study, including hormone receptor status and type of breast cancer. TS2 lists the antibodies used and the method by which immunohistochemistry stained breast cancer specimens were score

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5acd0fdfae7012857e9eb219c491ea51
https://doi.org/10.1158/0008-5472.22418925.v1

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Nanopore Identification of Single Nucleotide Mutations in Circulating Tumor DNA by Multiplexed Ligation

Autor: Abhilash Gadi, Amit Meller, Robert J. Schneider, Nitza Burck, Michelle Patkin Nehrer, Tal Gilboa

Publikováno v: Clinical Chemistry

Background Circulating tumor DNAs (ctDNAs) are highly promising cancer biomarkers, potentially applicable for noninvasive liquid biopsy and disease monitoring. However, to date, sequencing of ctDNAs has proven to be challenging primarily due to small

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc22fb60d5f9ca41558fc2670235f711
https://doi.org/10.1093/clinchem/hvaa328

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The Activin/FLRG Pathway Associates with Poor COVID-19 Outcomes in Hospitalized Patients

Autor: Lori G Morton, Adelekan Oyejide, Qian Zhang, Li Pan, David J. Glass, Sara Hamon, Jianing Xu, Anita Boyapati, Dharani Ajithdoss, Tea Shavlakadze, Christos A. Kyratsous, Matthew F. Wipperman, Matthew Wakai, Raphael Simonson, Megan McAleavy, Abhilash Gadi, Peter J. Ehmann

Publikováno v: Molecular and Cellular Biology

A subset of hospitalized COVID-19 patients, particularly the aged and those with comorbidities, develop the most severe form of the disease, characterized by acute respiratory disease syndrome (ARDS), coincident with experiencing a “cytokine storm.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a59724a06977a486eaf71e3e3019dda9
https://doi.org/10.1128/mcb.00467-21

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The Effect of Fluid Flow Shear Stress and Substrate Stiffness on Yes-Associated Protein (YAP) Activity and Osteogenesis in Murine Osteosarcoma Cells

Autor: Upal Basu-Roy, Alka Mansukhani, Oran D. Kennedy, Thomas R. Coughlin, Ali Sana, Abhilash Gadi, Caroline M. Curtin, Kevin Voss

Publikováno v: Cancers, Vol 13, Iss 3128, p 3128 (2021)
Cancers
Volume 13
Issue 13

Osteosarcoma (OS) is an aggressive bone cancer originating in the mesenchymal lineage. Prognosis for metastatic disease is poor, with a mortality rate of approximately 40%
OS is an aggressive disease for which new treatments are needed. All bone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9977dea2d4798a781be93a46801d19
https://www.mdpi.com/2072-6694/13/13/3128

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Inflammatory Breast Cancer Promotes Development of M2 Tumor-Associated Macrophages and Cancer Mesenchymal Cells through a Complex Chemokine Network

Autor: Amanda Valeta-Magara, Beth Walters, Viviana Volta, Shah Giashuddin, Hua Zhong, Robert J. Schneider, Rezina Arju, Abhilash Gadi

Publikováno v: Cancer Res

Inflammatory breast cancer (IBC) is a highly aggressive form of breast cancer that displays profound cancer stem cell (CSC) and mesenchymal features that promote rapid metastasis. Another hallmark of IBC is high infiltration of M2 tumor-associated (i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d914529dcd5ba4c829183c752ccd7ae
https://doi.org/10.1158/0008-5472.can-17-2158

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mTORC1/2 inhibition re-sensitizes platinum-resistant ovarian cancer by disrupting selective translation of DNA damage and survival mRNAs

Autor: Abhilash Gadi, Amanda Ernlund, Gizelka David-West, Robert J. Schneider

Publikováno v: Oncotarget. 9:33064-33076

// Gizelka David-West 1,4,* , Amanda Ernlund 2,* , Abhilash Gadi 2 and Robert J. Schneider 2,3 1 Division of Gynecologic Oncology, New York University School of Medicine, New York, NY, USA 2 Department of Microbiology, New York University School of M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285ae4ecbd4816762ae0f57d839db1a4
https://doi.org/10.18632/oncotarget.25869

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Myeloid Zinc Finger 1 and GA Binding Protein Co-Operate with Sox2 in Regulating the Expression of Yes-Associated Protein 1 in Cancer Cells

Autor: Alka Mansukhani, Upal Roy, Narendra Verma, Abhilash Gadi, Giulia Maurizi, Claudio Basilico

Publikováno v: Stem Cells. 35:2340-2350

The transcription factor (TF) yes-associated protein 1 (YAP1) is a major effector of the tumor suppressive Hippo signaling pathway and is also necessary to maintain pluripotency in embryonic stem cells. Elevated levels of YAP1 expression antagonize t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f42f2a348090eba0d0bf9c340d2bbcae
https://doi.org/10.1002/stem.2705

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Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM

Autor: Nina Ripin, Julien Boudet, Malgorzata M. Duszczyk, Alexandra Hinniger, Michael Faller, Miroslav Krepl, Abhilash Gadi, Robert J. Schneider, Jiří Šponer, Nicole C. Meisner-Kober, Frédéric H.-T. Allain

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 116 (8)

Human antigen R (HuR) is a key regulator of cellular mRNAs containing adenylate/uridylate–rich elements (AU-rich elements; AREs). These are a major class of cis elements within 3′ untranslated regions, targeting these mRNAs for rapid degradation.

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