Výsledky vyhledávání - "Abhijit Shukla"

Genome-scale screens identify JNK-JUN signaling as a barrier for pluripotency exit and endoderm differentiation

Publikováno v: Nature genetics

Human embryonic stem cells (ESCs) and human induced pluripotent stem cells hold great promise for cell-based therapies and drug discovery. However, homogeneous differentiation remains a major challenge, highlighting the need for understanding develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::595ec43a4e36057eb7153240d37e1277
https://pubmed.ncbi.nlm.nih.gov/31110351

Zobrazit plný text záznamu

Decoding the noncoding genome via large-scale CRISPR screens

Autor: Danwei Huangfu, Abhijit Shukla

Large portions of the human genome harbor functional noncoding elements, which can regulate a variety of biological processes and have important implications for disease risk and therapeutic outcomes. However, assigning specific functions to noncodin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4393a0dd5ee36ef931398a2642bacdf7
https://europepmc.org/articles/PMC6252135/

Zobrazit plný text záznamu

TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells

Autor: Nipun Verma, Danwei Huangfu, Louis C. Dore, Chuan He, Bobbie Pelham-Webb, Andrei V. Krivtsov, Federico Gonzalez, Olivier Elemento, Qing V. Li, Chan Jung Chang, Heng Pan, Virginia Teijeiro, Abhijit Shukla, Eirini P. Papapetrou

Publikováno v: Nature genetics

TET enzymes oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), which can lead to DNA demethylation. However, direct connections between TET-mediated DNA demethylation and transcriptional output are difficult to establish owing to chall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3636cb6a3dcb06221507924f5b7ba7
https://pubmed.ncbi.nlm.nih.gov/29255266

Zobrazit plný text záznamu

Sgf29p Facilitates the Recruitment of TATA Box Binding Protein but Does Not Alter SAGA’s Global Structural Integrity in Vivo

Autor: Abhijit Shukla, Geetha Durairaj, Shweta Lahudkar, Sukesh R. Bhaumik

Publikováno v: Biochemistry. 51:706-714

Although Sgf29p has been biochemically implicated as a component of SAGA (Spt-Ada-Gcn5 acetyltransferase), its precise mechanism of action in transcription is not clearly understood in vivo. Here, using a formaldehyde-based in vivo cross-linking and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f32e693bdb4a3c52eb14ad8a3bddc2
https://doi.org/10.1021/bi201708z

Zobrazit plný text záznamu

Role for Dpy-30 in ES Cell-Fate Specification by Regulation of H3K4 Methylation within Bivalent Domains

Autor: Abhijit Shukla, Xiaoling Wang, Robert G. Roeder, Wei Yi Chen, Bradley E. Bernstein, Hao Jiang

Publikováno v: Cell. 144(4):513-525

SummaryHistone H3K4 methylation is associated with active genes and, along with H3K27 methylation, is part of a bivalent chromatin mark that typifies poised developmental genes in embryonic stem cells (ESCs). However, its functional roles in ESC main

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d271c3c643032226575160943b28ae5

Zobrazit plný text záznamu

The mRNA cap-binding complex stimulates the formation of pre-initiation complex at the promoter via its interaction with Mot1p in vivo

Autor: Geetha Durairaj, Abhijit Shukla, Sukesh R. Bhaumik, Nadia Stanojevic, Shweta Lahudkar, Pratibha Bajwa

Publikováno v: Nucleic Acids Research

The cap-binding complex (CBC) binds to the cap structure of mRNA to protect it from exonucleases as well as to regulate downstream post-transcriptional events, translational initiation and nonsense-mediated mRNA decay. However, its role in regulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5164fbfddb9be5fbd4c193710a43455
http://europepmc.org/articles/PMC3064766

Zobrazit plný text záznamu

Regulation of Chromatin Assembly/Disassembly by Rtt109p, a Histone H3 Lys56-specific Acetyltransferase, in Vivo

Autor: Priyasri Chaurasia, Geetha Durairaj, Shweta Lahudkar, Sukesh R. Bhaumik, Shivani Malik, Abhijit Shukla

Publikováno v: Journal of Biological Chemistry. 285:30472-30479

Rtt109p, a histone acetyltransferase, associates with active genes and acetylates lysine 56 on histone H3 in Saccharomyces cerevisiae. However, the functional role of Rtt109p or H3 Lys(56) acetylation in chromatin assembly/disassembly (and hence gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27316b1974050eb485eca7f569ff931
https://doi.org/10.1074/jbc.m110.113225

Zobrazit plný text záznamu

Publisher Correction: TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells

Autor: Eirini P. Papapetrou, Chuan He, Danwei Huangfu, Andrei V. Krivtsov, Nipun Verma, Louis C. Dore, Qing V. Li, Heng Pan, Virginia Teijeiro, Federico Gonzalez, Abhijit Shukla, Olivier Elemento, Bobbie Pelham-Webb, Chan Jung Chang

Publikováno v: Nature Genetics. 50:764-764

In the version of this article initially published, in the Methods, the Gene Expression Omnibus accession code for H3K36me3 ChIP–seq data was incorrectly given as GSM1003585 instead of GSM733725. The error has been corrected in the HTML, PDF and pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca70fb539ad8beb18b61d958b3d1cc83
https://doi.org/10.1038/s41588-017-0024-5

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání