Paclitaxel inhibits mRNA transport in axons

Autor: Ilja Bobylev, Abhijeet R. Joshi, Mohammed Barham, Christian Ritter, Wolfram F. Neiss, Ahmet Höke, Helmar C. Lehmann

Publikováno v: Neurobiology of Disease, Vol 82, Iss , Pp 321-331 (2015)

Paclitaxel is an integral component of solid tumor treatment. This chemotherapeutic agent provokes an often irreversible peripheral sensory neuropathy with pathological features of distal axonal degeneration. Current pathological concepts assume that

Externí odkaz: https://doaj.org/article/675f3519d420486787f49c96e3f94103

Impact of drug formulations on kinetics and toxicity in a preclinical model of paclitaxel-induced neuropathy

Autor: Ilja Bobylev, Abhijeet R. Joshi, Martin H. J. Wiesen, Ines Klein, Virginia Albert, Carsten Müller, Helmar C. Lehmann

Publikováno v: Journal of the peripheral nervous system : JPNSREFERENCES. 26(2)

Background and aims Peripheral neuropathy is a common side effect of paclitaxel. Clinical studies suggest that different paclitaxel formulations influence the severity and time course of paclitaxel-induced peripheral neuropathy. We compared two pacli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507d82736189aa11a41efa1e4fe713a0
https://pubmed.ncbi.nlm.nih.gov/33683765

Mapping axon initial segment structure and function by multiplexed proximity biotinylation

Autor: Matthew N. Rasband, Christophe Leterrier, Juan A. Oses-Prieto, Brian C. Lim, Cameron Smith, Abhijeet R. Joshi, Matthias Koenning, Donna Palmer, Philip Ng, Hamdan Hamdan, Tomohiro Torii, Alma L. Burlingame

Publikováno v: Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-019-13658-5⟩
Nature Communications, 2020, 11 (1), ⟨10.1038/s41467-019-13658-5⟩
BASE-Bielefeld Academic Search Engine

Axon initial segments (AISs) generate action potentials and regulate the polarized distribution of proteins, lipids, and organelles in neurons. While the mechanisms of AIS Na+ and K+ channel clustering are understood, the molecular mechanisms that st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fbdd0bc7adf2d7e52eb9d35ecc18b4f
https://escholarship.org/uc/item/6gb3n4f6

Paclitaxel inhibits mRNA transport in axons

Autor: Helmar C. Lehmann, Abhijeet R. Joshi, Wolfram F. Neiss, Christian Ritter, Mohammed Barham, Ilja Bobylev, Ahmet Hoke

Publikováno v: Neurobiology of Disease, Vol 82, Iss, Pp 321-331 (2015)

Paclitaxel is an integral component of solid tumor treatment. This chemotherapeutic agent provokes an often irreversible peripheral sensory neuropathy with pathological features of distal axonal degeneration. Current pathological concepts assume that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310648bc51af92d67830d14c51689df3
https://doi.org/10.1016/j.nbd.2015.07.006

Impact of Age and Polytherapy on Fingolimod Induced Bradycardia: a Preclinical Study

Autor: Toni Schneider, Christian Ritter, Abhijeet R. Joshi, Helmar C. Lehmann, Ilja Bobylev, Martin K.R. Svačina

Publikováno v: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 12(1)

Fingolimod is a an oral disease modifying drug for relapsing remitting multiple sclerosis (MS) preventing egress of B and T cells from lymph nodes. Relevant first dose adverse events include bradycardia and atrioventricular conduction slowing. Cardia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547d16a2691b6318e823cff7f75c6c16
https://pubmed.ncbi.nlm.nih.gov/28150133