Opportunities and Challenges in the Delivery of mRNA-Based Vaccines

Autor: Abishek Wadhwa, Anas Aljabbari, Abhijeet Lokras, Camilla Foged, Aneesh Thakur

Publikováno v: Pharmaceutics, Vol 12, Iss 2, p 102 (2020)

In the past few years, there has been increasing focus on the use of messenger RNA (mRNA) as a new therapeutic modality. Current clinical efforts encompassing mRNA-based drugs are directed toward infectious disease vaccines, cancer immunotherapies, t

Externí odkaz: https://doaj.org/article/0448043441a7465b892b92f6d65c2b5a

Simultaneous quantification of multiple RNA cargoes co-loaded into nanoparticle-based delivery systems

Autor: Abhijeet Lokras, Akash Chakravarty, Thomas Rades, Dennis Christensen, Henrik Franzyk, Aneesh Thakur, Camilla Foged

Publikováno v: Lokras, A G, Chakravarty, A, Rades, T, Christensen, D, Franzyk, H, Thakur, A & Foged, C 2022, ' Simultaneous quantification of multiple RNA cargoes co-loaded into nanoparticle-based delivery systems ', International Journal of Pharmaceutics, vol. 626, 122171 . https://doi.org/10.1016/j.ijpharm.2022.122171

Robust, sensitive, and versatile analytical methods are essential for quantification of RNA drug cargoes loaded into nanoparticle-based delivery systems. However, simultaneous quantification of multiple RNA cargoes co-loaded into nanoparticles remain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b92ba552f75e832293f398d2e715ff0
https://curis.ku.dk/ws/files/319401574/1_s2.0_S0378517322007256_main.pdf

Optimizing the Intracellular Delivery of Therapeutic Anti-inflammatory TNF-α siRNA to Activated Macrophages Using Lipidoid-Polymer Hybrid Nanoparticles

Autor: Kaushik Thanki, Abishek Wadhwa, Henrik Franzyk, Camilla Foged, Aneesh Thakur, Abhijeet Lokras

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 8 (2021)
Lokras, A, Thakur, A, Wadhwa, A, Thanki, K, Franzyk, H & Foged, C 2020, ' Optimizing the Intracellular Delivery of Therapeutic Anti-inflammatory TNF-α siRNA to Activated Macrophages Using Lipidoid-Polymer Hybrid Nanoparticles ', Frontiers in Bioengineering and Biotechnology, vol. 8, 601155 . https://doi.org/10.3389/fbioe.2020.601155
Frontiers in Bioengineering and Biotechnology

RNA interference (RNAi) has an unprecedented potential as a therapeutic strategy for reversibly silencing the expression of any gene. Therapeutic delivery of the RNAi mediator, i.e., small interfering RNA (siRNA), can be used to address diseases char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d7fc72eaecd6903b9a181ca1c23e048

Opportunities and Challenges in the Delivery of mRNA-Based Vaccines

Autor: Anas Aljabbari, Aneesh Thakur, Abhijeet Lokras, Abishek Wadhwa, Camilla Foged

Publikováno v: Pharmaceutics, Vol 12, Iss 2, p 102 (2020)
Pharmaceutics
Wadhwa, A, Aljabbari, A, Lokras, A, Foged, C & Thakur, A 2020, ' Opportunities and Challenges in the Delivery of mRNA-based Vaccines ', Pharmaceutics, vol. 12, no. 2, 102 . https://doi.org/10.3390/pharmaceutics12020102

In the past few years, there has been increasing focus on the use of messenger RNA (mRNA) as a new therapeutic modality. Current clinical efforts encompassing mRNA-based drugs are directed toward infectious disease vaccines, cancer immunotherapies, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be675f1768458671fba5a3b7c1f5d29b
https://www.mdpi.com/1999-4923/12/2/102

Identification of Factors of Importance for Spray Drying of Small Interfering RNA-Loaded Lipidoid-Polymer Hybrid Nanoparticles for Inhalation

Autor: Abhijeet Lokras, Guillermo Cano-Garcia, Fabrice Rose, Henrik Franzyk, Kaushik Thanki, Cypriane Dormenval, Aneesh Thakur, Camilla Foged, Abishek Wadhwa

Publikováno v: Pharmaceutical research. 36(10)

Background With the recent approval of the first small interfering RNA (siRNA) therapeutic formulated as nanoparticles, there is increased incentive for establishing the factors of importance for the design of stable solid dosage forms of such comple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599ad996a8632b1a802bda0a07fef335
https://pubmed.ncbi.nlm.nih.gov/31376020