Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Abhijeet Kapoor"'
Autor:
Allan I. Paxson, Loren H. Chang, Jaime M. C. Gard, William L. Harryman, Colin S. Nelson, Stella B. Salmon, Kendra D. Marr, Leah M. Wachsmuth, Anita Ramanathan, Jing Ran, Abhijeet Kapoor, Juan J. Marugan, Mark J. Henderson, Tino W. Sanchez, Anne E. Cress
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
In 2023, approximately 288,300 new diagnoses of prostate cancer will occur, with 34,700 disease-related deaths. Death from prostate cancer is associated with metastasis, enabled by progression of tumor phenotypes and successful extracapsular extensio
Externí odkaz:
https://doaj.org/article/a456044366374dd1a817306440c69162
Autor:
Sandip Basak, Yvonne Gicheru, Abhijeet Kapoor, Megan L. Mayer, Marta Filizola, Sudha Chakrapani
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Serotonin receptors (5-HT3R) belong to the pentameric ligand-gated ion channel superfamily and mediate excitatory postsynaptic signaling. Here the authors present the high-resolution cryo-EM structure of 5-HT3AR bound with the competitive antagonist
Externí odkaz:
https://doaj.org/article/b766ed4a222d442488eb15a659c8ec8c
Autor:
Sandip Basak, Arvind Kumar, Steven Ramsey, Eric Gibbs, Abhijeet Kapoor, Marta Filizola, Sudha Chakrapani
Publikováno v:
eLife, Vol 9 (2020)
Serotonin receptors (5-HT3AR) play a crucial role in regulating gut movement, and are the principal target of setrons, a class of high-affinity competitive antagonists, used in the management of nausea and vomiting associated with radiation and chemo
Externí odkaz:
https://doaj.org/article/ff96e1ad8c044f679da8e43683623a1d
Autor:
Taylor ET Hughes, John Smith Del Rosario, Abhijeet Kapoor, Aysenur Torun Yazici, Yevgen Yudin, Edwin C Fluck III, Marta Filizola, Tibor Rohacs, Vera Y Moiseenkova-Bell
Publikováno v:
eLife, Vol 8 (2019)
Transient receptor potential vanilloid 5 (TRPV5) is a highly calcium selective ion channel that acts as the rate-limiting step of calcium reabsorption in the kidney. The lack of potent, specific modulators of TRPV5 has limited the ability to probe th
Externí odkaz:
https://doaj.org/article/a82f5f6720e94648810a1aa64e4d1450
Autor:
Abhijeet Kapoor, Alex Travesset
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e108846 (2014)
HRAS regulates cell growth promoting signaling processes by cycling between active (GTP-bound) and inactive (GDP-bound) states. Understanding the transition mechanism is central for the design of small molecules to inhibit the formation of RAS-driven
Externí odkaz:
https://doaj.org/article/b283a0ce0bc74cd28c4e31fc762743ce
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26509 (2011)
Human dopamine β-hydroxylase (DBH) is an important therapeutic target for complex traits. Several single nucleotide polymorphisms (SNPs) have also been identified in DBH with potential adverse physiological effect. However, difficulty in obtaining d
Externí odkaz:
https://doaj.org/article/1aa67441010040a2b8cd888b2651892a
Publikováno v:
In Journal of Oral Biology and Craniofacial Research September-October 2022 12(5):547-551
Autor:
Samir Parekh, Aneel K. Aggarwal, Marta Filizola, Jian Jin, Lapo Alinari, Adrian Wiestner, Youssef Youssef, Alessandro Laganà, Fanye Meng, Donna Edwards, H. Ümit Kaniskan, Clement Lee, Paola Bisignano, Abhijeet Kapoor, Rinku Jain, Violetta V. Leshchenko, Stephanie Christie, Shashidhar S. Jatiani
Supplemental Figures, Tables, Methods and References
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef9cb4d8d753100930ecad8482c9466
https://doi.org/10.1158/1078-0432.22480592
https://doi.org/10.1158/1078-0432.22480592
Autor:
Samir Parekh, Aneel K. Aggarwal, Marta Filizola, Jian Jin, Lapo Alinari, Adrian Wiestner, Youssef Youssef, Alessandro Laganà, Fanye Meng, Donna Edwards, H. Ümit Kaniskan, Clement Lee, Paola Bisignano, Abhijeet Kapoor, Rinku Jain, Violetta V. Leshchenko, Stephanie Christie, Shashidhar S. Jatiani
Purpose:Mantle cell lymphoma (MCL) is a fatal subtype of non–Hodgkin lymphoma. SOX11 transcription factor is overexpressed in the majority of nodal MCL. We have previously reported that B cell–specific overexpression of SOX11 promotes MCL pathoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f82f638734e360c97d22cab8ae4c43e
https://doi.org/10.1158/1078-0432.c.6530477
https://doi.org/10.1158/1078-0432.c.6530477
Autor:
Ashley E. Owens, Michael J. Iannotti, Tino W. Sanchez, Ty Voss, Abhijeet Kapoor, Matthew D. Hall, Juan J. Marugan, Sam Michael, Noel Southall, Mark J. Henderson
Publikováno v:
ACS Chem Biol
Cellular thermal shift assay (CETSA) is a valuable method to confirm target engagement within a complex cellular environment, by detecting changes in a protein's thermal stability upon ligand binding. The classical CETSA method measures changes in th