Výsledky vyhledávání - "Abhay Uthale"

Elevated USP9X drives early-to-late-stage oral tumorigenesis via stabilisation of anti-apoptotic MCL-1 protein and impacts outcome in oral cancers

Autor: Swapnil Oak, Prajakta Kalkar, Sushil S Pawar, Prasad Sulkshane, Abhay Uthale, Tanuja Teni, Sudhir Nair, Rahul Patil, Priyanka Rajput, Harshada Wani, Sagar Pawar, Rohit Waghole, Pallavi Rane

Publikováno v: Br J Cancer

Background Overexpression of anti-apoptotic MCL-1 protein in oral squamous cell carcinoma (OSCC) is linked to disease progression, therapy resistance and poor outcome. Despite its characteristic short half-life owing to ubiquitin-proteasome-dependent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd4c199aab7451be7b431903611ec81
https://doi.org/10.1038/s41416-021-01421-x

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Identification of bicyclic compounds that act as dual inhibitors of Bcl-2 and Mcl-1

Autor: Abhay Uthale, Aarti Anantram, Prasad Sulkshane, Mariam Degani, Tanuja Teni

Publikováno v: Molecular diversity.

Elevated expression of anti-apoptotic proteins, such as Bcl-2 and Mcl-1 contributes to poor prognosis and resistance to current treatment modalities in multiple cancers. Here, we report the design, synthesis and characterization of benzimidazole chal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac6f11df3fc32047501a191772c49cc
https://pubmed.ncbi.nlm.nih.gov/35909144

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