Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Abhay Kotecha"'
Autor:
Victoria I. Cushing, Adrian F. Koh, Junjie Feng, Kaste Jurgaityte, Alexander Bondke, Sebastian H. B. Kroll, Marion Barbazanges, Bodo Scheiper, Ash K. Bahl, Anthony G. M. Barrett, Simak Ali, Abhay Kotecha, Basil J. Greber
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Rational design of next-generation therapeutics can be facilitated by high-resolution structures of drug targets bound to small-molecule inhibitors. However, application of structure-based methods to macromolecules refractory to crystallizat
Externí odkaz:
https://doaj.org/article/a393bf7c13c14f7a93881e19f56dabfa
Autor:
Airi Tarutani, Sofia Lövestam, Xianjun Zhang, Abhay Kotecha, Andrew C. Robinson, David M. A. Mann, Yuko Saito, Shigeo Murayama, Taisuke Tomita, Michel Goedert, Sjors H. W. Scheres, Masato Hasegawa
Publikováno v:
FEBS Open Bio, Vol 13, Iss 8, Pp 1394-1404 (2023)
The formation of amyloid filaments through templated seeding is believed to underlie the propagation of pathology in most human neurodegenerative diseases. A widely used model system to study this process is to seed amyloid filament formation in cult
Externí odkaz:
https://doaj.org/article/e6a04ddc628d42669dccef432f209b08
Autor:
Kimberly A Dolan, Mandira Dutta, David M Kern, Abhay Kotecha, Gregory A Voth, Stephen G Brohawn
Publikováno v:
eLife, Vol 11 (2022)
SARS-CoV-2 encodes four structural proteins incorporated into virions, spike (S), envelope (E), nucleocapsid (N), and membrane (M). M plays an essential role in viral assembly by organizing other structural proteins through physical interactions and
Externí odkaz:
https://doaj.org/article/e30b73ef0ebc4151b16b3ceff1fe0988
Autor:
Luiza Mendonça, Dapeng Sun, Jiying Ning, Jiwei Liu, Abhay Kotecha, Mateusz Olek, Thomas Frosio, Xiaofeng Fu, Benjamin A. Himes, Alex B. Kleinpeter, Eric O. Freed, Jing Zhou, Christopher Aiken, Peijun Zhang
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Mendonça et al. determine the structures of both in vitro assemblies of the HIV structural precursor protein Gag and Gag viral-like particles (VLPs) to 4.2 Å and 4.5 Å resolutions, using cryo-electron tomography and subtomogram averaging. This stu
Externí odkaz:
https://doaj.org/article/9ab2d7c26554447ba2a91fac3949925b
Autor:
Max Renner, Wanwisa Dejnirattisai, Loïc Carrique, Itziar Serna Martin, Dimple Karia, Serban L. Ilca, Shu F. Ho, Abhay Kotecha, Jeremy R. Keown, Juthathip Mongkolsapaya, Gavin R. Screaton, Jonathan M. Grimes
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Here, the authors provide cryo-EM structures of mature and immature Spondweni virus, defining the furin recognition site at high resolution, and identifying a lipid that binds E upon capsid maturation and is also present in Zika and Dengue virions.
Externí odkaz:
https://doaj.org/article/c1e60ed8086c474ea0ccecd7e38b5686
Publikováno v:
IUCrJ, Vol 9, Iss 6, Pp 713-714 (2022)
Externí odkaz:
https://doaj.org/article/d42d5d5932c94100934fae1fd5add1ee
Autor:
Sofia Lövestam, Fujiet Adrian Koh, Bart van Knippenberg, Abhay Kotecha, Alexey G Murzin, Michel Goedert, Sjors HW Scheres
Publikováno v:
eLife, Vol 11 (2022)
Abundant filamentous inclusions of tau are characteristic of more than 20 neurodegenerative diseases that are collectively termed tauopathies. Electron cryo-microscopy (cryo-EM) structures of tau amyloid filaments from human brain revealed that disti
Externí odkaz:
https://doaj.org/article/5a43a79ce71b4064afeb8da1c61ff062
Autor:
Kuan-Ying A. Huang, Daming Zhou, Elizabeth E. Fry, Abhay Kotecha, Peng-Nien Huang, Shu-Li Yang, Kuo-Chien Tsao, Yhu-Chering Huang, Tzou-Yien Lin, Jingshan Ren, David I. Stuart
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
To date, no therapeutic agents against enterovirus 71, the causative agent of hand, foot and mouth disease, exist. Here, using Cryo-EM Huang et al. characterize two plasmablast-derived plateau-binding neutralizing antibodies conferring effective prot
Externí odkaz:
https://doaj.org/article/4b4769b88b7b49b0ba87e9ad7d89cbcd
Autor:
Geoff Sutton, Dapeng Sun, Xiaofeng Fu, Abhay Kotecha, Corey W. Hecksel, Daniel K. Clare, Peijun Zhang, David I. Stuart, Mark Boyce
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Reoviridae undergo a complex assembly pathway in the host cell. Here the authors use cryo-electron tomography to visualize the assembly stages of mammalian orthoreovirus revealing a single shelled intermediate with gross similarity to an early assemb
Externí odkaz:
https://doaj.org/article/08db4ba63126425986073b664fcf412b
Autor:
Yuguang Zhao, Daming Zhou, Tao Ni, Dimple Karia, Abhay Kotecha, Xiangxi Wang, Zihe Rao, E. Yvonne Jones, Elizabeth E. Fry, Jingshan Ren, David I. Stuart
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Here, the authors provide the structure of mature Coxsackie Virus A10 alone and in complex with its receptor KREMEN1, and of A-particles. This shows how the receptor spans the viral canyon and suggests that receptor binding triggers pocket factor rel
Externí odkaz:
https://doaj.org/article/be45168770654d1e8ea295697ed054b8