Dendritic Cell-Mediated Cross-Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARS-CoV-2.

Autor: Lázaro-Gorines R; Cancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, 28041, Spain.; Immuno-Oncology and Immunotherapy Group, Instituto de Investigación Sanitaria 12 de Octubre (imas12), Madrid, 28041, Spain.; H12O-CNIO Cancer Immunotherapy Clinical Research Unit, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, 28029, Spain., Pérez P; Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, 28049, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Madrid, 28029, Spain., Heras-Murillo I; Immunobiology lab, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, 28029, Spain., Adán-Barrientos I; Immunobiology lab, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, 28029, Spain., Albericio G; Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, 28049, Spain., Astorgano D; Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, 28049, Spain., Flores S; Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, 28049, Spain., Luczkowiak J; Virology and HIV/AIDS Group, Instituto de Investigación Sanitaria 12 de Octubre (imas12), Madrid, 28041, Spain., Labiod N; Virology and HIV/AIDS Group, Instituto de Investigación Sanitaria 12 de Octubre (imas12), Madrid, 28041, Spain., Harwood SL; Department of Molecular Biology and Genetics - Protein Science, Aarhus University, Aarhus, 80000, Denmark., Segura-Tudela A; Cancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, 28041, Spain.; Immuno-Oncology and Immunotherapy Group, Instituto de Investigación Sanitaria 12 de Octubre (imas12), Madrid, 28041, Spain.; H12O-CNIO Cancer Immunotherapy Clinical Research Unit, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, 28029, Spain., Rubio-Pérez L; Cancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, 28041, Spain.; Immuno-Oncology and Immunotherapy Group, Instituto de Investigación Sanitaria 12 de Octubre (imas12), Madrid, 28041, Spain.; H12O-CNIO Cancer Immunotherapy Clinical Research Unit, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, 28029, Spain.; Chair for Immunology UFV/Merck, Universidad Francisco de Vitoria (UFV), Pozuelo de Alarcón, Madrid, 28223, Spain., Nugraha Y; Protein Crystallography Unit, Structural Biology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, 28029, Spain., Shang X; Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD, 20850, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Li Y; Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD, 20850, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.; The Center for Biomolecular Therapeutics, Rockville, MD, 20850, USA., Alfonso C; Centro de Investigaciones Biológicas Margarita Salas (CIB), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, 28040, Spain., Adipietro KA; The Center for Biomolecular Therapeutics, Rockville, MD, 20850, USA.; Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Abeyawardhane DL; Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD, 20850, USA.; The Center for Biomolecular Therapeutics, Rockville, MD, 20850, USA.; Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Navarro R; Department of Antibody Engineering, Leadartis SL, Tres Cantos, Madrid, 28002, Spain., Compte M; Department of Antibody Engineering, Leadartis SL, Tres Cantos, Madrid, 28002, Spain., Yu W; Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD, 20850, USA., MacKerell AD Jr; Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD, 20850, USA.; Computer Aided Drug Design Center, Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, 21201, USA.; Center for Biomolecular Therapeutics (CBT), University of Maryland School of Medicine, Baltimore, MD 21201, USA., Sanz L; Molecular Immunology Unit, Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, 28220, Spain., Weber DJ; Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD, 20850, USA.; The Center for Biomolecular Therapeutics, Rockville, MD, 20850, USA., Blanco FJ; Centro de Investigaciones Biológicas Margarita Salas (CIB), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, 28040, Spain., Esteban M; Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, 28049, Spain., Pozharski E; Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD, 20850, USA.; The Center for Biomolecular Therapeutics, Rockville, MD, 20850, USA., Godoy-Ruiz R; Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD, 20850, USA.; The Center for Biomolecular Therapeutics, Rockville, MD, 20850, USA., Muñoz IG; Protein Crystallography Unit, Structural Biology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, 28029, Spain., Delgado R; Virology and HIV/AIDS Group, Instituto de Investigación Sanitaria 12 de Octubre (imas12), Madrid, 28041, Spain.; Department of Microbiology, Hospital Universitario 12 de Octubre, Madrid, 28041, Spain.; Department of Medicine, Universidad Complutense de Madrid, Madrid, 28040, Spain., Sancho D; Immunobiology lab, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, 28029, Spain., García-Arriaza J; Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, 28049, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Madrid, 28029, Spain., Álvarez-Vallina L; Cancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, 28041, Spain.; Immuno-Oncology and Immunotherapy Group, Instituto de Investigación Sanitaria 12 de Octubre (imas12), Madrid, 28041, Spain.; H12O-CNIO Cancer Immunotherapy Clinical Research Unit, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, 28029, Spain.; Chair for Immunology UFV/Merck, Universidad Francisco de Vitoria (UFV), Pozuelo de Alarcón, Madrid, 28223, Spain.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2023 Dec; Vol. 10 (34), pp. e2304818. Date of Electronic Publication: 2023 Oct 20.

The Importance of Therapeutically Targeting the Binary Toxin from Clostridioides difficile .

Autor: Abeyawardhane DL; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.; Baltimore-Institute for Bioscience and Biotechnology Research, University of Maryland-Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA.; The Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Godoy-Ruiz R; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.; Baltimore-Institute for Bioscience and Biotechnology Research, University of Maryland-Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA.; The Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Adipietro KA; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.; The Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Varney KM; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.; Baltimore-Institute for Bioscience and Biotechnology Research, University of Maryland-Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA.; The Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Rustandi RR; Merck & Co., Inc., Kenilworth, NJ 07033, USA., Pozharski E; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.; Baltimore-Institute for Bioscience and Biotechnology Research, University of Maryland-Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA.; The Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Weber DJ; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.; Baltimore-Institute for Bioscience and Biotechnology Research, University of Maryland-Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA.; The Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2021 Mar 13; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 13.

Biometals as conformational modulators of α-synuclein photochemical crosslinking.

Autor: Abeyawardhane DL; Department of Chemistry, Virginia Commonwealth University, Richmond, VA, 23284, USA., Curry AM; Department of Chemistry, Virginia Commonwealth University, Richmond, VA, 23284, USA., Forney AK; Department of Chemistry, Virginia Commonwealth University, Richmond, VA, 23284, USA., Roberts JW; Department of Chemistry, Virginia Commonwealth University, Richmond, VA, 23284, USA., Lucas HR; Department of Chemistry, Virginia Commonwealth University, Richmond, VA, 23284, USA. hrlucas@vcu.edu.

Publikováno v: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry [J Biol Inorg Chem] 2019 Dec; Vol. 24 (8), pp. 1261-1268. Date of Electronic Publication: 2019 Nov 14.

C-Terminal Cu ^II Coordination to α-Synuclein Enhances Aggregation.

Autor: Abeyawardhane DL; Department of Chemistry , Virginia Commonwealth University , Richmond , Virginia 23284 , United States., Heitger DR; Department of Chemistry , Virginia Commonwealth University , Richmond , Virginia 23284 , United States., Fernández RD; Department of Chemistry , Virginia Commonwealth University , Richmond , Virginia 23284 , United States., Forney AK; Department of Chemistry , Virginia Commonwealth University , Richmond , Virginia 23284 , United States., Lucas HR; Department of Chemistry , Virginia Commonwealth University , Richmond , Virginia 23284 , United States.

Publikováno v: ACS chemical neuroscience [ACS Chem Neurosci] 2019 Mar 20; Vol. 10 (3), pp. 1402-1410. Date of Electronic Publication: 2018 Nov 13.

Iron Redox Chemistry Promotes Antiparallel Oligomerization of α-Synuclein.

Autor: Abeyawardhane DL; Department of Chemistry , Virginia Commonwealth University , Richmond , Virginia 23284 , United States., Fernández RD; Department of Chemistry , Virginia Commonwealth University , Richmond , Virginia 23284 , United States., Murgas CJ; Department of Chemistry , Virginia Commonwealth University , Richmond , Virginia 23284 , United States., Heitger DR; Department of Chemistry , Virginia Commonwealth University , Richmond , Virginia 23284 , United States., Forney AK; Department of Chemistry , Virginia Commonwealth University , Richmond , Virginia 23284 , United States., Crozier MK; Department of Chemistry , Virginia Commonwealth University , Richmond , Virginia 23284 , United States., Lucas HR; Department of Chemistry , Virginia Commonwealth University , Richmond , Virginia 23284 , United States.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2018 Apr 18; Vol. 140 (15), pp. 5028-5032. Date of Electronic Publication: 2018 Apr 09.