Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Abena S. Agyeman"'
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Following a comprehensive and coordinated effort between CBER and CDER, FDA established a table of acceptable surrogate endpoints (SEs) to support drug marketing applications. The publicly accessible SE Table was first published in 2018 as a response
Externí odkaz:
https://doaj.org/article/9d138317cdc44e908bd0cdcf5fb67a24
Publikováno v:
Cancer Research. 73:P4-16
Background: Few promising molecular targets exist for chemoresistant triple negative breast cancer (TNBC). Our laboratory has previously demonstrated that a subset of TNBCs express high glucocorticoid receptor (GR) levels. In breast epithelial cells,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::118b9421fcb628f47229fba288141873
https://doi.org/10.1158/0008-5472.sabcs13-p4-16-05
https://doi.org/10.1158/0008-5472.sabcs13-p4-16-05
Autor:
Ben A. Hall, Paul A. Volden, Mark C. Harbeck, Larissa Belova, Deanna R. Brickley, Abena S. Agyeman, Wei Wu, Michael W. Roe, Richard F. Kopp, Suzanne D. Conzen
Publikováno v:
Journal of Biological Chemistry. 288:32708-32719
Serum and glucocorticoid-regulated kinase 1 (SGK1) encodes a phosphatidylinositol 3-kinase-dependent serine/threonine kinase that is rapidly induced in response to cellular stressors and is an important cell survival signal. Previous studies have sug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4801150e44df0ee7fc99dd728cce73d
https://doi.org/10.1074/jbc.m113.507210
https://doi.org/10.1074/jbc.m113.507210
Autor:
Patrick G. Shaw, Akhilesh Pandey, Raghothama Chaerkady, Thomas W. Kensler, Nancy E. Davidson, Kala Visvanathan, Abena S. Agyeman
Publikováno v:
Breast Cancer Research and Treatment. 132:175-187
Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, is a potent inhibitor of experimental mammary carcinogenesis and may be an effective, safe chemopreventive agent for use in humans. SFN acts in part on the Keap1/Nrf2 pathway to r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb71e195d263626c2188836fc1ba2501
https://doi.org/10.1007/s10549-011-1536-9
https://doi.org/10.1007/s10549-011-1536-9
Autor:
Barry L. Fanburg, Michael J. Segel, Ruben D. Chevere, Jill M. Angelosanto, Regina M. Day, Yuichiro J. Suzuki, Abena S. Agyeman
Publikováno v:
Biochemical Pharmacology. 71:386-397
The chronic phase of pulmonary arterial hypertension (PAH) is associated with vascular remodeling, especially thickening of the smooth muscle layer of large pulmonary arteries and muscularization of small pulmonary vessels, which normally have no ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a212aeb90ac5e8d82fd69a1b028dfe
https://doi.org/10.1016/j.bcp.2005.10.035
https://doi.org/10.1016/j.bcp.2005.10.035
Autor:
Amy Simon, Barry L. Fanburg, Brent H. Cochran, Satoe Takahashi, Bathsheeba Andrahbi, Regina M. Day, Mariano Severgnini, Liliana M. Rozo, Abena S. Agyeman
Publikováno v:
Cell Biochemistry and Biophysics. 42:263-276
Serotonin (5-HT) stimulates superoxide release, phosphorylation of p42/p44 mitogen-activated protein kinase (MAPK), and DNA synthesis in bovine pulmonary artery smooth muscle cells. Both p42/p44 MAPK and reactive oxygen species (ROS) generation are r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0287da0e1fa0e3c4476cfc8173f0f614
https://doi.org/10.1385/cbb:42:3:263
https://doi.org/10.1385/cbb:42:3:263
Publikováno v:
Cancer Research. 76:3100-3100
Glucocorticoid receptor (GR) activity in triple-negative breast cancer (TNBC) is associated with cell survival and chemotherapy resistance. Targetable molecular drivers for TNBC have been difficult to identify and therefore standard treatment remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1298ec8af2777d4e728f30b9c21d4226
https://doi.org/10.1158/1538-7445.am2016-3100
https://doi.org/10.1158/1538-7445.am2016-3100
Autor:
Patricia A. Egner, Abena S. Agyeman, John D. Groopman, Jianguo Chen, Paul Talalay, Kala Visvanathan, Jed W. Fahey, Thomas W. Kensler, Tao Yang Chen
Publikováno v:
Natural Products in Cancer Prevention and Therapy ISBN: 9783642345746
Sulforaphane is a promising agent under preclinical evaluation in many models of disease prevention. This bioactive phytochemical affects many molecular targets in cellular and animal models; however, amongst the most sensitive is Keap1, a key sensor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd0b507f2f6575ae55cddaceffeb3e1
https://doi.org/10.1007/128_2012_339
https://doi.org/10.1007/128_2012_339
Autor:
Lâle Aka Burk, Wing-Yee Yeung, Carolyn M. Turcotte, Adam C. Hall, Abena S. Agyeman, Brooke A. Betts
Publikováno v:
European journal of pharmacology. 506(1)
Effects of common monoterpenoid alcohols and ketones were investigated on recombinant human gamma-aminobutyric acid A (GABAA; alpha1beta2gamma2s) and glycine (alpha1 homomers) receptors expressed in Xenopus oocytes. GABA currents were enhanced by coa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274c0aa8eaf3cc49c83dd74f528e90af
https://pubmed.ncbi.nlm.nih.gov/15588619
https://pubmed.ncbi.nlm.nih.gov/15588619
Autor:
Harrys K.C. Jacob, Nancy E. Davidson, Kala Visvanathan, Abena S. Agyeman, Akhilesh Pandey, Thomas W. Kensler, Patrick G. Shaw, Raghothama Chaerkady
Publikováno v:
Cancer Prevention Research. 3:A47-A47
The goal of this study is the discovery of biomarkers reflecting the pharmacodynamic action of sulforaphane (SFN), initially using normal human mammary epithelial MCF10A cells and then in tissue obtained from healthy patients undergoing reduction mam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38c2d94a846ba130003054982d9ba7fc
https://doi.org/10.1158/1940-6207.prev-10-a47
https://doi.org/10.1158/1940-6207.prev-10-a47