Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Abel Silva-Garcia"'
Publikováno v:
Drug Design, Development and Therapy. 12:1599-1607
Mira P Patel,1 Vincent Siu,1 Abel Silva-Garcia,1 Qing Xu,2 Zhe Li,2 Donna Oksenberg1 1Biology Department, Global Blood Therapeutics Inc., South San Francisco, CA, USA; 2Chemistry Department, Global Blood Therapeutics Inc., South San Francisco, CA, US
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2935e44494dd6b93c21c4a5127af941e
https://doi.org/10.2147/dddt.s157570
https://doi.org/10.2147/dddt.s157570
Autor:
Ying Zhang, James R. Partridge, Qiong Xu, Peter Rademacher, Zhe Li, Andreas Betz, Haijuan Shi, Hing Sham, Abel Silva-Garcia, Li Zhang, Xubo Ma, Bin Liu, Qing Xu, Yuqing Shan, Yunjin Hu
Publikováno v:
ACS Medicinal Chemistry Letters. 8:185-190
A series of macrocyclic analogues were designed and synthesized based on the cocrystal structure of small molecule plasma kallikrein (pKal) inhibitor, 2, with the pKal protease domain. This led to the discovery of a potent macrocyclic pKal inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d537b94897348a671c4135a5641c88
https://doi.org/10.1021/acsmedchemlett.6b00384
https://doi.org/10.1021/acsmedchemlett.6b00384
Autor:
Brian Metcalf, Abel Silva-Garcia, Rebeca M. Choy, Zhe Li, James R. Partridge, Chul Yu, Hing Sham
Publikováno v:
Journal of structural biology. 206(2)
Plasma kallikrein (pKal) is a serine protease responsible for cleaving high-molecular-weight kininogen to produce the pro-inflammatory peptide, bradykinin. Unregulated pKal activity can lead to hereditary angioedema (HAE) following excess bradykinin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf88af62441dec56e6f6e2c4f69b8c55
https://pubmed.ncbi.nlm.nih.gov/30876891
https://pubmed.ncbi.nlm.nih.gov/30876891
Autor:
Athiwat Hutchaleelaha, Harris Jason R, Qing Xu, Donna Oksenberg, Matthew P. Jacobson, Carl Johnson, Larysa N. Patskovska, Zhe Li, Joyce James, Qing Lu, Paulvannan Kumar, Chihyuan Chuang, Donghong Xu, Yury Patskovsky, Lan Hua, Abel Silva-Garcia, Kobina Dufu, Brian Metcalf, Bradley P Morgan, James R. Partridge, Stephen L Gwaltney, Calvin Yee, Mira Patel, Steven C. Almo
We report the discovery of a new potent allosteric effector of sickle cell hemoglobin, GBT440 (36), that increases the affinity of hemoglobin for oxygen and consequently inhibits its polymerization when subjected to hypoxic conditions. Unlike earlier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474bb23099c36d4a59ac8cad2e76a0d7
https://europepmc.org/articles/PMC5346980/
https://europepmc.org/articles/PMC5346980/
Autor:
David R. Archer, Athiwat Hutchaleelaha, Mira Patel, Brian Metcalf, Larysa N. Patskovska, Chihyuan Chuang, Zhe Li, Qing Xu, Yury Patskovsky, Chengjing Zhou, Steven C. Almo, Donna Oksenberg, Abel Silva-Garcia, Uma Sinha, Kobina Dufu
Publikováno v:
British journal of haematology. 175(1)
Summary A major driver of the pathophysiology of sickle cell disease (SCD) is polymerization of deoxygenated haemoglobin S (HbS), which leads to sickling and destruction of red blood cells (RBCs) and end-organ damage. Pharmacologically increasing the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3da859d0033d27cb65d4d24bab32e93
https://pubmed.ncbi.nlm.nih.gov/27410726
https://pubmed.ncbi.nlm.nih.gov/27410726
Publikováno v:
Drug Design, Development & Therapy; 2018, Vol. 12, p1599-1607, 9p
Autor:
Oksenberg, Donna, Dufu, Kobina, Patel, Mira P., Chuang, Chihyuan, Li, Zhe, Xu, Qing, Silva‐Garcia, Abel, Zhou, Chengjing, Hutchaleelaha, Athiwat, Patskovska, Larysa, Patskovsky, Yury, Almo, Steven C., Sinha, Uma, Metcalf, Brian W., Archer, David R.
Publikováno v:
British Journal of Haematology; Oct2016, Vol. 175 Issue 1, p141-153, 13p, 4 Charts, 6 Graphs