Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Abel Sanchez-Aguilera"'
Publikováno v:
Repisalud
Instituto de Salud Carlos III (ISCIII)
Cellular and Molecular Life Sciences
Instituto de Salud Carlos III (ISCIII)
Cellular and Molecular Life Sciences
Research in the last decade has shown that hematopoietic stem cells (HSCs) interact with and are modulated by a complex multicellular microenvironment in the bone marrow, which includes both the HSC progeny and multiple non-hematopoietic cell types.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5af7af64019da8543acf93118b9fbf5
https://doi.org/10.1007/s00018-016-2306-y
https://doi.org/10.1007/s00018-016-2306-y
Publikováno v:
Annals of the New York Academy of Sciences. 1335:32-44
The interactions of stromal cells with hematopoietic cells in the bone marrow have long been a subject of research, but only recently have technologies allowed us to dissect them at the stem cell level. On the other hand, limitations of these technic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13714f50bae9bd54724e170260006b4f
https://doi.org/10.1111/nyas.12641
https://doi.org/10.1111/nyas.12641
Autor:
Sandra Muntión, Joan Isern, Pontus Lundberg, Jürg Schwaller, Xavier Langa, Radek C. Skoda, Simón Méndez-Ferrer, Alexandar Tzankov, Lorena Arranz, Abel Sanchez-Aguilera, Daniel Martín-Pérez, Dar-Ming Lai, Yi-Shiuan Tzeng
Publikováno v:
Nature
Myeloproliferative neoplasms (MPNs) are diseases caused by mutations in the haematopoietic stem cell (HSC) compartment. Most MPN patients have a common acquired mutation of Janus kinase 2 (JAK2) gene in HSCs that renders this kinase constitutively ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d77372151fca3204e16d049ff7e64f3
https://doi.org/10.1038/nature13383
https://doi.org/10.1038/nature13383
Autor:
Lucia Kubovcakova, Jürg Schwaller, Xavier Langa, Joan Isern, Simón Méndez-Ferrer, Andrés García-García, Vaia Stavropoulou, Daniel Martín-Pérez, Abel Sanchez-Aguilera, Radek C. Skoda, Lorena Arranz, Sandra Martín-Salamanca
Publikováno v:
Cell Stem Cell
Cell stem cell
Europe PubMed Central
Cell stem cell
Europe PubMed Central
Summary Estrogens are potent regulators of mature hematopoietic cells; however, their effects on primitive and malignant hematopoietic cells remain unclear. Using genetic and pharmacological approaches, we observed differential expression and functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da2b753aa514a86c27c390884fa220e
Autor:
David T. Scadden, Cristina Lo Celso, Kristina Brumme, Subhanjan Mondal, Hongbo R. Luo, Adrienne M. Dorrance, Francesca Ferraro, Abel Sanchez-Aguilera, Yun-Jung Lee, David A. Williams, Chaekyun Kim
Publikováno v:
Proceedings of the National Academy of Sciences. 108:9607-9612
Engraftment and maintenance of hematopoietic stem and progenitor cells (HSPC) depend on their ability to respond to extracellular signals from the bone marrow microenvironment, but the critical intracellular pathways integrating these signals remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7530dc2a7a63ac77c63c0eed5b7516df
https://doi.org/10.1073/pnas.1102018108
https://doi.org/10.1073/pnas.1102018108
mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization
Autor:
Shan Jiang, Lynda Chin, Boyi Gan, David A. Williams, Abel Sanchez-Aguilera, Ergun Sahin, Kenneth L. Scott, David J. Kwiatkowski, Ronald A. DePinho
Publikováno v:
Proceedings of the National Academy of Sciences. 105:19384-19389
The Tuberous Sclerosis Complex component, TSC1, functions as a tumor suppressor via its regulation of diverse cellular processes, particularly cell growth. TSC1 exists in a complex with TSC2 and functions primarily as a key negative regulator of mamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06edb668287c6bd431ebb8f746802bd3
https://doi.org/10.1073/pnas.0810584105
https://doi.org/10.1073/pnas.0810584105
Publikováno v:
Molecularcellular oncology. 3(1)
We recently reported that estrogens regulate survival, proliferation, and self-renewal of hematopoietic stem cells and progenitors via estrogen receptor-α activation. Through its proapoptotic effect on malignant progenitors, tamoxifen treatment bloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b03aa167c511d7e61c727cc51cdc542c
https://pubmed.ncbi.nlm.nih.gov/27308525
https://pubmed.ncbi.nlm.nih.gov/27308525
Autor:
Alexandar Tzankov, Juerg Schwaller, Simón Méndez-Ferrer, Abel Sanchez-Aguilera, Daniel Martín-Pérez, Claire Fielding, Dorian Forte, María García-Fernández, Vaya Stavropoulou
Publikováno v:
Blood. 130:94-94
Modulation of oxidative stress as well as metabolic adjustments are key aspects in cancer stem cell-derived diseases, such as acute myelogenous leukemia (AML). Metabolic reprogramming in leukemia seems to be influenced by the crosstalk of malignant c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::790687ee5c510c9403446d5d30cd91a0
https://doi.org/10.1182/blood.v130.suppl_1.94.94
https://doi.org/10.1182/blood.v130.suppl_1.94.94
Autor:
Simón Méndez-Ferrer, Vaia Stavropoulou, Abel Sanchez-Aguilera, Alexandar Tzankov, Daniel Martín-Pérez, Jürg Schwaller
Publikováno v:
Cancer Research. 76:IA23-IA23
Myeloproliferative neoplasms (MPNs) are hematological malignancies originated by hematopoietic stem cells (HSCs) carrying mutations, most frequently in JAK2, CALR or MPL genes. These diseases, which cannot be cured in most cases, are characterized by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::987844a92961901501ebb8d46a2dc602
https://doi.org/10.1158/1538-7445.fbcr15-ia23
https://doi.org/10.1158/1538-7445.fbcr15-ia23
Autor:
Ashley M. Ficker, Xosé R. Bustelo, Shuhong Shen, Susan K. Dunn, Rebecca A. Santho, Amitava Sengupta, David A. Williams, Abel Sanchez-Aguilera, Jose A. Cancelas, Yi Zheng, Michael W. Deininger, Malav Madhu, Xabier Agirre, Jorden Arnett, John P. Perentesis, Kyung Hee Chang, Ashley M. Kuenzi
Publikováno v:
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
Blood; Vol 120
instname
Blood; Vol 120
Despite the introduction of tyrosine kinase inhibitor therapy, the prognosis for p190-BCR-ABL+ acute lymphoblastic leukemia remains poor. In the present study, we present the cellular and molecular roles of the Rho GTPase guanine nucleotide exchange
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89bb79e67ed950197b4c411ac2f78f14
https://hdl.handle.net/10171/36318
https://hdl.handle.net/10171/36318
