Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Abel Jacobus Bronkhorst"'
Publikováno v:
Tumor Biology, Vol 42 (2020)
In vitro characterization of cell-free DNA using two-dimensional cell culture models is emerging as an important step toward an improved understanding of the physical and biological characteristics of cell-free DNA in human biology. However, precise
Externí odkaz:
https://doaj.org/article/47037875d3a9449d87c9abc652eae7d4
Comparison of methods for the quantification of cell-free DNA isolated from cell culture supernatant
Publikováno v:
Tumor Biology, Vol 41 (2019)
Gaining a better understanding of the biological properties of cell-free DNA constitutes an important step in the development of clinically meaningful cell-free DNA–based tests. Since the in vivo characterization of cell-free DNA is complicated by
Externí odkaz:
https://doaj.org/article/58467d036fcf40a3b0705a7992a1280b
Publikováno v:
Data in Brief, Vol 6, Iss , Pp 326-329 (2016)
Evaluating the kinetics of cell-free DNA (cfDNA) in the blood of cancer patients could be a strong auxiliary component to the molecular characterization of cfDNA, but its potential clinical significance is obscured by the absence of an analytical con
Externí odkaz:
https://doaj.org/article/b3e341c4c5f04732a94dec616b638b97
Autor:
Abel Jacobus Bronkhorst, Johannes F Wentzel, Vida Ungerer, Dimetrie L Peters, Janine Aucamp, Etienne Pierre de Villiers, Stefan Holdenrieder, Piet J Pretorius
Publikováno v:
Tumor Biology, Vol 40 (2018)
The true importance of cell-free DNA in human biology, together with the potential scale of its clinical utility, is tarnished by a lack of understanding of its composition and origin. In investigating the cell-free DNA present in the growth medium o
Externí odkaz:
https://doaj.org/article/97cf857cfc46473ca7562642d2ea3b1a
Publikováno v:
Journal of Laboratory Medicine. 46:283-294
Programmed cell death, accidental cell degradation and active extrusion constantly lead to the release of DNA fragments into human body fluids from virtually all cell and tissue types. It is widely accepted that these cell-free DNA (cfDNA) molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bf2e7d6539ab895c32464d8e9d822c2
https://doi.org/10.1515/labmed-2022-0031
https://doi.org/10.1515/labmed-2022-0031
Publikováno v:
Journal of Laboratory Medicine. 46:247-253
Early detection is crucial for optimal treatment and prognosis of cancer. New approaches for pan-cancer screening comprise the comprehensive characterization of circulating tumor DNA (ctDNA) in plasma by next generation sequencing and molecular profi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::459530a5b681f872bda5198f34dee12f
https://doi.org/10.1515/labmed-2022-0029
https://doi.org/10.1515/labmed-2022-0029
Publikováno v:
Journal of Laboratory Medicine. 46:207-224
Genomes of diverse origins are continuously shed into human body fluids in the form of fragmented cell-free DNA (cfDNA). These molecules maintain the genetic and epigenetic codes of their originating source, and often carry additional layers of uniqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61693bb7f3d901301ed9ff77822c5bb7
https://doi.org/10.1515/labmed-2022-0030
https://doi.org/10.1515/labmed-2022-0030
Autor:
Vida Ungerer, Stefan Holdenrieder, Priscilla Van den Ackerveken, Abel Jacobus Bronkhorst, Marielle Herzog
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Scientific Reports
Scientific Reports
Recent advances in basic research have unveiled several strategies for improving the sensitivity and specificity of cell-free DNA (cfDNA) based assays, which is a prerequisite for broadening its clinical use. Included among these strategies is levera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce929d5e2768e9b5128dbc7ec4ec5b34
https://doaj.org/article/3d21f76d3af146979aaf89c988ffa78d
https://doaj.org/article/3d21f76d3af146979aaf89c988ffa78d
Publikováno v:
Stem Cell Reports
Human stem cells bear a great potential for multiple therapeutic applications but at the same time constitute a major threat to human health in the form of cancer stem cells. The molecular processes that govern stem cell maintenance or differentiatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ab55c46ae1456f7c45d14419f4a20e
https://doi.org/10.1016/j.stemcr.2020.11.002
https://doi.org/10.1016/j.stemcr.2020.11.002
Autor:
Mark D. Pertile, Sonya Parpart-Li, Sarah R. Greytak, Muhammed Murtaza, Helen M. Moore, Kelly B. Engel, Abel Jacobus Bronkhorst
Publikováno v:
Clin Cancer Res
Circulating cell-free DNA (cfDNA) is rapidly transitioning from discovery research to an important tool in clinical decision making. However, the lack of harmonization of preanalytic practices across institutions may compromise the reproducibility of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b8c48b6ce37afe40522393a13aa3abd
https://doi.org/10.1158/1078-0432.ccr-19-3015
https://doi.org/10.1158/1078-0432.ccr-19-3015