Rapid and accurate remethylation of DNA in Dnmt3a- deficient hematopoietic cells with restoration of DNMT3A activity.

Autor: Li Y; Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA., Abel HJ; Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA., Cai M; Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA., LaValle TA; Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA., Yin T; Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA., Helton NM; Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA., Smith AM; Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA., Miller CA; Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA., Ley TJ; Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.

Publikováno v: Science advances [Sci Adv] 2024 Feb 02; Vol. 10 (5), pp. eadk8598. Date of Electronic Publication: 2024 Jan 31.

A draft human pangenome reference.

Autor: Liao WW; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.; Center for Genomic Health, Yale University School of Medicine, New Haven, CT, USA.; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, USA., Asri M; Genomics Institute, University of California, Santa Cruz, CA, USA., Ebler J; Institute for Medical Biometry and Bioinformatics, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; Center for Digital Medicine, Heinrich Heine University, Düsseldorf, Germany., Doerr D; Institute for Medical Biometry and Bioinformatics, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; Center for Digital Medicine, Heinrich Heine University, Düsseldorf, Germany., Haukness M; Genomics Institute, University of California, Santa Cruz, CA, USA., Hickey G; Genomics Institute, University of California, Santa Cruz, CA, USA., Lu S; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.; Center for Genomic Health, Yale University School of Medicine, New Haven, CT, USA., Lucas JK; Genomics Institute, University of California, Santa Cruz, CA, USA., Monlong J; Genomics Institute, University of California, Santa Cruz, CA, USA., Abel HJ; Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA., Buonaiuto S; Institute of Genetics and Biophysics, National Research Council, Naples, Italy., Chang XH; Genomics Institute, University of California, Santa Cruz, CA, USA., Cheng H; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Chu J; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA., Colonna V; Institute of Genetics and Biophysics, National Research Council, Naples, Italy.; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA., Eizenga JM; Genomics Institute, University of California, Santa Cruz, CA, USA., Feng X; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Fischer C; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA., Fulton RS; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Garg S; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Copenhagen, Denmark., Groza C; Quantitative Life Sciences, McGill University, Montréal, Québec, Canada., Guarracino A; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA.; Genomics Research Centre, Human Technopole, Milan, Italy., Harvey WT; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA., Heumos S; Quantitative Biology Center (QBiC), University of Tübingen, Tübingen, Germany.; Biomedical Data Science, Department of Computer Science, University of Tübingen, Tübingen, Germany., Howe K; Tree of Life, Wellcome Sanger Institute, Hinxton, Cambridge, UK., Jain M; Northeastern University, Boston, MA, USA., Lu TY; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, USA., Markello C; Genomics Institute, University of California, Santa Cruz, CA, USA., Martin FJ; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Mitchell MW; Coriell Institute for Medical Research, Camden, NJ, USA., Munson KM; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA., Mwaniki MN; Department of Computer Science, University of Pisa, Pisa, Italy., Novak AM; Genomics Institute, University of California, Santa Cruz, CA, USA., Olsen HE; Genomics Institute, University of California, Santa Cruz, CA, USA., Pesout T; Genomics Institute, University of California, Santa Cruz, CA, USA., Porubsky D; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA., Prins P; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA., Sibbesen JA; Center for Health Data Science, University of Copenhagen, Copenhagen, Denmark., Sirén J; Genomics Institute, University of California, Santa Cruz, CA, USA., Tomlinson C; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA., Villani F; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA., Vollger MR; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.; Division of Medical Genetics, University of Washington School of Medicine, Seattle, WA, USA., Antonacci-Fulton LL; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA., Baid G; Google, Mountain View, CA, USA., Baker CA; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA., Belyaeva A; Google, Mountain View, CA, USA., Billis K; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Carroll A; Google, Mountain View, CA, USA., Chang PC; Google, Mountain View, CA, USA., Cody S; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA., Cook DE; Google, Mountain View, CA, USA., Cook-Deegan RM; Barrett and O'Connor Washington Center, Arizona State University, Washington, DC, USA., Cornejo OE; Department of Ecology and Evolutionary Biology, University of California, Santa Cruz, CA, USA., Diekhans M; Genomics Institute, University of California, Santa Cruz, CA, USA., Ebert P; Institute for Medical Biometry and Bioinformatics, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; Center for Digital Medicine, Heinrich Heine University, Düsseldorf, Germany.; Core Unit Bioinformatics, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Fairley S; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Fedrigo O; Vertebrate Genome Laboratory, The Rockefeller University, New York, NY, USA., Felsenfeld AL; National Institutes of Health (NIH)-National Human Genome Research Institute, Bethesda, MD, USA., Formenti G; Vertebrate Genome Laboratory, The Rockefeller University, New York, NY, USA., Frankish A; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Gao Y; Center for Computational and Genomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Garrison NA; Institute for Society and Genetics, College of Letters and Science, University of California, Los Angeles, CA, USA.; Institute for Precision Health, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Giron CG; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Green RE; Department of Biomolecular Engineering, University of California, Santa Cruz, CA, USA.; Dovetail Genomics, Scotts Valley, CA, USA., Haggerty L; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Hoekzema K; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA., Hourlier T; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Ji HP; Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Kenny EE; Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Koenig BA; Program in Bioethics and Institute for Human Genetics, University of California, San Francisco, CA, USA., Kolesnikov A; Google, Mountain View, CA, USA., Korbel JO; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Kordosky J; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA., Koren S; Genome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Lee H; Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Lewis AP; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA., Magalhães H; Institute for Medical Biometry and Bioinformatics, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; Center for Digital Medicine, Heinrich Heine University, Düsseldorf, Germany., Marco-Sola S; Computer Sciences Department, Barcelona Supercomputing Center, Barcelona, Spain.; Departament d'Arquitectura de Computadors i Sistemes Operatius, Universitat Autònoma de Barcelona, Barcelona, Spain., Marijon P; Institute for Medical Biometry and Bioinformatics, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.; Center for Digital Medicine, Heinrich Heine University, Düsseldorf, Germany., McCartney A; Genome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., McDaniel J; Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD, USA., Mountcastle J; Vertebrate Genome Laboratory, The Rockefeller University, New York, NY, USA., Nattestad M; Google, Mountain View, CA, USA., Nurk S; Genome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Olson ND; Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD, USA., Popejoy AB; Department of Public Health Sciences, University of California, Davis, CA, USA., Puiu D; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA., Rautiainen M; Genome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Regier AA; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA., Rhie A; Genome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Sacco S; Department of Ecology and Evolutionary Biology, University of California, Santa Cruz, CA, USA., Sanders AD; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany., Schneider VA; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA., Schultz BI; National Institutes of Health (NIH)-National Human Genome Research Institute, Bethesda, MD, USA., Shafin K; Google, Mountain View, CA, USA., Smith MW; National Institutes of Health (NIH)-National Human Genome Research Institute, Bethesda, MD, USA., Sofia HJ; National Institutes of Health (NIH)-National Human Genome Research Institute, Bethesda, MD, USA., Abou Tayoun AN; Al Jalila Genomics Center of Excellence, Al Jalila Children's Specialty Hospital, Dubai, UAE.; Center for Genomic Discovery, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAE., Thibaud-Nissen F; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA., Tricomi FF; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Wagner J; Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD, USA., Walenz B; Genome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Wood JMD; Tree of Life, Wellcome Sanger Institute, Hinxton, Cambridge, UK., Zimin AV; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.; Center for Computational Biology, Johns Hopkins University, Baltimore, MD, USA., Bourque G; Department of Human Genetics, McGill University, Montréal, Québec, Canada.; Canadian Center for Computational Genomics, McGill University, Montréal, Québec, Canada.; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan., Chaisson MJP; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, USA., Flicek P; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Phillippy AM; Genome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Zook JM; Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD, USA., Eichler EE; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Haussler D; Genomics Institute, University of California, Santa Cruz, CA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Wang T; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Jarvis ED; Vertebrate Genome Laboratory, The Rockefeller University, New York, NY, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.; Laboratory of Neurogenetics of Language, The Rockefeller University, New York, NY, USA., Miga KH; Genomics Institute, University of California, Santa Cruz, CA, USA., Garrison E; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA. egarris5@uthsc.edu., Marschall T; Institute for Medical Biometry and Bioinformatics, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany. tobias.marschall@hhu.de.; Center for Digital Medicine, Heinrich Heine University, Düsseldorf, Germany. tobias.marschall@hhu.de., Hall IM; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. ira.hall@yale.edu.; Center for Genomic Health, Yale University School of Medicine, New Haven, CT, USA. ira.hall@yale.edu., Li H; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA. hli@jimmy.harvard.edu.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. hli@jimmy.harvard.edu., Paten B; Genomics Institute, University of California, Santa Cruz, CA, USA. bpaten@ucsc.edu.

Publikováno v: Nature [Nature] 2023 May; Vol. 617 (7960), pp. 312-324. Date of Electronic Publication: 2023 May 10.

Influence of dietary non-essential amino acid profile on growth performance and amino acid metabolism of Nile tilapia, Oreochromis niloticus (L.)

Autor: Gaye-Siessegger, J., Focken, U., Abel, Hj., Becker, K.

Publikováno v: In Comparative Biochemistry and Physiology, Part A 2007 146(1):71-77

Somatic Dnmt3a inactivation leads to slow, canonical DNA methylation loss in murine hematopoietic cells.

Autor: Smith AM; Division of Oncology, Section of Stem Cell Biology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Verdoni AM; Division of Oncology, Section of Stem Cell Biology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Abel HJ; Division of Oncology, Section of Stem Cell Biology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Chen DY; Division of Dermatology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Ketkar S; Division of Oncology, Section of Stem Cell Biology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Leight ER; Division of Oncology, Section of Stem Cell Biology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Miller CA; Division of Oncology, Section of Stem Cell Biology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Ley TJ; Division of Oncology, Section of Stem Cell Biology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

Publikováno v: IScience [iScience] 2022 Mar 03; Vol. 25 (4), pp. 104004. Date of Electronic Publication: 2022 Mar 03 (Print Publication: 2022).

Haplotype-resolved diverse human genomes and integrated analysis of structural variation.

Autor: Ebert P; Heinrich Heine University, Medical Faculty, Institute for Medical Biometry and Bioinformatics, Moorenstraße 20, 40225 Düsseldorf, Germany., Audano PA; Department of Genome Sciences, University of Washington School of Medicine, 3720 15th Avenue NE, Seattle, WA 98195-5065, USA., Zhu Q; The Jackson Laboratory for Genomic Medicine, 10 Discovery Drive, Farmington, CT 06032, USA., Rodriguez-Martin B; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Meyerhofstraße 1, 69117 Heidelberg, Germany., Porubsky D; Department of Genome Sciences, University of Washington School of Medicine, 3720 15th Avenue NE, Seattle, WA 98195-5065, USA., Bonder MJ; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Meyerhofstraße 1, 69117 Heidelberg, Germany.; Division of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Sulovari A; Department of Genome Sciences, University of Washington School of Medicine, 3720 15th Avenue NE, Seattle, WA 98195-5065, USA., Ebler J; Heinrich Heine University, Medical Faculty, Institute for Medical Biometry and Bioinformatics, Moorenstraße 20, 40225 Düsseldorf, Germany., Zhou W; Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, 100 Washtenaw Avenue, Ann Arbor, MI 48109, USA., Serra Mari R; Heinrich Heine University, Medical Faculty, Institute for Medical Biometry and Bioinformatics, Moorenstraße 20, 40225 Düsseldorf, Germany., Yilmaz F; The Jackson Laboratory for Genomic Medicine, 10 Discovery Drive, Farmington, CT 06032, USA., Zhao X; Center for Genomic Medicine, Massachusetts General Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics and Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Hsieh P; Department of Genome Sciences, University of Washington School of Medicine, 3720 15th Avenue NE, Seattle, WA 98195-5065, USA., Lee J; Bionano Genomics, San Diego, CA 92121, USA., Kumar S; Program in Computational Biology and Bioinformatics, Yale University, BASS 432 and 437, 266 Whitney Avenue, New Haven, CT 06520, USA., Lin J; School of Automation Science and Engineering, Faculty of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, China., Rausch T; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Meyerhofstraße 1, 69117 Heidelberg, Germany., Chen Y; Department of Genetics and Informatics Institute, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Ren J; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA., Santamarina M; Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.; Department of Zoology, Genetics, and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain., Höps W; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Meyerhofstraße 1, 69117 Heidelberg, Germany., Ashraf H; Heinrich Heine University, Medical Faculty, Institute for Medical Biometry and Bioinformatics, Moorenstraße 20, 40225 Düsseldorf, Germany., Chuang NT; Institute for Genome Sciences, University of Maryland School of Medicine, 670 W Baltimore Street, Baltimore, MD 21201, USA., Yang X; School of Computer Science and Technology, Faculty of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, China., Munson KM; Department of Genome Sciences, University of Washington School of Medicine, 3720 15th Avenue NE, Seattle, WA 98195-5065, USA., Lewis AP; Department of Genome Sciences, University of Washington School of Medicine, 3720 15th Avenue NE, Seattle, WA 98195-5065, USA., Fairley S; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK., Tallon LJ; Institute for Genome Sciences, University of Maryland School of Medicine, 670 W Baltimore Street, Baltimore, MD 21201, USA., Clarke WE; New York Genome Center, New York, NY 10013, USA., Basile AO; New York Genome Center, New York, NY 10013, USA., Byrska-Bishop M; New York Genome Center, New York, NY 10013, USA., Corvelo A; New York Genome Center, New York, NY 10013, USA., Evani US; New York Genome Center, New York, NY 10013, USA., Lu TY; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA., Chaisson MJP; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA., Chen J; Department of Computer and Information Sciences, Temple University, Philadelphia, PA 19122, USA., Li C; Department of Computer and Information Sciences, Temple University, Philadelphia, PA 19122, USA., Brand H; Center for Genomic Medicine, Massachusetts General Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics and Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Wenger AM; Pacific Biosciences of California, Menlo Park, CA 94025, USA., Ghareghani M; Max Planck Institute for Informatics, Saarland Informatics Campus E1.4, 66123 Saarbrücken, Germany.; Saarbrücken Graduate School of Computer Science, Saarland University, Saarland Informatics Campus E1.3, 66123 Saarbrücken, Germany.; Heinrich Heine University, Medical Faculty, Institute for Medical Biometry and Bioinformatics, Moorenstraße 20, 40225 Düsseldorf, Germany., Harvey WT; Department of Genome Sciences, University of Washington School of Medicine, 3720 15th Avenue NE, Seattle, WA 98195-5065, USA., Raeder B; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Meyerhofstraße 1, 69117 Heidelberg, Germany., Hasenfeld P; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Meyerhofstraße 1, 69117 Heidelberg, Germany., Regier AA; Department of Medicine, Washington University, St. Louis, MO 63108, USA., Abel HJ; Department of Medicine, Washington University, St. Louis, MO 63108, USA., Hall IM; Department of Genetics, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA., Flicek P; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK., Stegle O; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Meyerhofstraße 1, 69117 Heidelberg, Germany.; Division of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Gerstein MB; Program in Computational Biology and Bioinformatics, Yale University, BASS 432 and 437, 266 Whitney Avenue, New Haven, CT 06520, USA., Tubio JMC; Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.; Department of Zoology, Genetics, and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain., Mu Z; Genetics, Genomics, and Systems Biology, University of Chicago, Chicago, IL 60637, USA., Li YI; Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA., Shi X; Department of Computer and Information Sciences, Temple University, Philadelphia, PA 19122, USA., Hastie AR; Bionano Genomics, San Diego, CA 92121, USA., Ye K; School of Automation Science and Engineering, Faculty of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, China.; Department of Human Genetics, University of Michigan, 1241 E. Catherine Street, Ann Arbor, MI 48109, USA., Chong Z; Department of Genetics and Informatics Institute, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Sanders AD; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Meyerhofstraße 1, 69117 Heidelberg, Germany., Zody MC; New York Genome Center, New York, NY 10013, USA., Talkowski ME; Center for Genomic Medicine, Massachusetts General Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02114, USA.; Program in Medical and Population Genetics and Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Mills RE; Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, 100 Washtenaw Avenue, Ann Arbor, MI 48109, USA.; Department of Human Genetics, University of Michigan, 1241 E. Catherine Street, Ann Arbor, MI 48109, USA., Devine SE; Institute for Genome Sciences, University of Maryland School of Medicine, 670 W Baltimore Street, Baltimore, MD 21201, USA., Lee C; The Jackson Laboratory for Genomic Medicine, 10 Discovery Drive, Farmington, CT 06032, USA. eee@gs.washington.edu tobias.marschall@hhu.de jan.korbel@embl.org charles.lee@jax.org.; Precision Medicine Center, The First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, 710061, Shaanxi, China.; Department of Graduate Studies-Life Sciences, Ewha Womans University, Ewhayeodae-gil, Seodaemun-gu, Seoul 120-750, South Korea., Korbel JO; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Meyerhofstraße 1, 69117 Heidelberg, Germany. eee@gs.washington.edu tobias.marschall@hhu.de jan.korbel@embl.org charles.lee@jax.org.; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK., Marschall T; Heinrich Heine University, Medical Faculty, Institute for Medical Biometry and Bioinformatics, Moorenstraße 20, 40225 Düsseldorf, Germany. eee@gs.washington.edu tobias.marschall@hhu.de jan.korbel@embl.org charles.lee@jax.org., Eichler EE; Department of Genome Sciences, University of Washington School of Medicine, 3720 15th Avenue NE, Seattle, WA 98195-5065, USA. eee@gs.washington.edu tobias.marschall@hhu.de jan.korbel@embl.org charles.lee@jax.org.; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2021 Apr 02; Vol. 372 (6537). Date of Electronic Publication: 2021 Feb 25.