Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Abeer F. Alharbi"'
Autor:
Abeer F. Alharbi, John Parrington
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-12 (2021)
Abstract Recent studies have implicated important roles for endolysosomal ion channels in cancer biology. We used UK Biobank data to characterise the relationships between genetic variants in two genes coding for endolysosomal ion channels—i.e. TPC
Externí odkaz:
https://doaj.org/article/29bbd94cdc4b41759574581c532ba94b
Autor:
Abdullah Alsultan, Wael A. Alghamdi, Jahad Alghamdi, Abeer F. Alharbi, Abdullah Aljutayli, Ahmed Albassam, Omar Almazroo, Saeed Alqahtani
Publikováno v:
Saudi Pharmaceutical Journal, Vol 28, Iss 10, Pp 1217-1227 (2020)
Drug development, from preclinical to clinical studies, is a lengthy and complex process. There is an increased interest in the Kingdom of Saudi Arabia (KSA) to promote innovation, research and local content including clinical trials (Phase I-IV). Cu
Externí odkaz:
https://doaj.org/article/f1f28a8e4c3344b688db0ebc2fb274f3
Autor:
Abeer F. Alharbi, John Parrington
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The role of endolysosomal Ca2+ signalling in immunity has been a subject of increasing interest in recent years. Here, we discuss evolving knowledge relating to the contribution of endolysosomal Ca2+ channels that include TPCs, TRPMLs, and P2X4R in p
Externí odkaz:
https://doaj.org/article/b96996b3edd14e1b810b74d0531701bd
Autor:
Abeer F. Alharbi, John Parrington
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Ca2+ homeostasis is dysregulated in cancer cells and affects processes such as tumorigenesis, angiogenesis, autophagy, progression, and metastasis. Emerging evidence has suggested that endolysosomal cation channels sustain several cancer hallmarks in
Externí odkaz:
https://doaj.org/article/45fa566dfabf41ee88ea6072320d927b
Autor:
Abeer F. Alharbi, Pamala A. Jacobson, James Fisher, Takuto Takahashi, Nathan Rubin, Angela R. Smith, Mark N. Kirstein
Publikováno v:
International Journal of Clinical Pharmacology and Therapeutics
Fungal CYP51A (14α-sterol demethylase) is the target of an azole antifungal, voriconazole (VCZ), which also partially inhibits human CYP51A1. Hepatotoxicity is a common adverse effect of azoles, which is reported to be caused by altered gene express
Autor:
Abeer F. Alharbi, Abdullah Aljutayli, Saeed Alqahtani, Ahmed A. Albassam, Wael A. Alghamdi, Omar Almazroo, Jahad Alghamdi, Abdullah Alsultan
Publikováno v:
Saudi Pharmaceutical Journal : SPJ
Saudi Pharmaceutical Journal, Vol 28, Iss 10, Pp 1217-1227 (2020)
Saudi Pharmaceutical Journal, Vol 28, Iss 10, Pp 1217-1227 (2020)
Drug development, from preclinical to clinical studies, is a lengthy and complex process. There is an increased interest in the Kingdom of Saudi Arabia (KSA) to promote innovation, research and local content including clinical trials (Phase I-IV). Cu
Publikováno v:
Trends in Pharmacological Sciences
Two-pore channels (TPCs) are cation-permeable channels located on endolysosomal membranes and important mediators of intracellular Ca2+ signalling. TPCs are involved in various pathophysiological processes, including cell growth and development, meta
Autor:
Abeer F. Alharbi, John Parrington
Publikováno v:
Cell chemical biology. 28(8)
Growing evidence implicates a vital role for TPC2/Ca2+ signaling in pathophysiological processes attributed to cancer, raising questions regarding the utility of TPC2 as a cancer therapeutic target. In this issue of Cell Chemical Biology, Muller et a
Autor:
Mark N. Kirstein, Angela R. Smith, Mutaz M. Jaber, Pamala A. Jacobson, Takuto Takahashi, Abeer F. Alharbi, Maryam A. Mohamud, James Fisher
Publikováno v:
Antimicrob Agents Chemother
Prophylactic voriconazole use is recommended for children undergoing hematopoietic cell transplantation (HCT). Dosing considerations are essential, due to the narrow therapeutic window of voriconazole. Known covariates do not sufficiently explain the
Autor:
Michael A. Maddaus, Mark N. Kirstein, Abeer F. Alharbi, Robert A. Kratzke, Kinjal Sanghavi, Jonathan D'Cunha
Publikováno v:
Cancer Chemotherapy and Pharmacology. 83:387-391
PURPOSE: We investigated the safety, pharmacokinetics, and efficacy of gemcitabine administered via bronchial artery infusion (BAI) and IV infusion in advanced NSCLC patients. METHODS: Patients were eligible if they had received at least two prior cy