Mechanistic insights into the C55-P targeting lipopeptide antibiotics revealed by structure-activity studies and high-resolution crystal structures

Autor: Wood, Thomas M., Zeronian, Matthieu R., Buijs, Ned, Bertheussen, Kristine, Abedian, Hanieh K., Johnson, Aidan V., Pearce, Nicholas M., Lutz, Martin, Kemmink, Johan, Seirsma, Tjalling, Hamoen, Leendert W., Janssen, Bert J. C., Martin, Nathaniel I., Afd Chemical Biology and Drug Discovery, Sub Structural Biochemistry, Structural Biochemistry, Pharmacology

Publikováno v: Chemical Science, 13(10), 2985-2991. Royal Society of Chemistry (RSC)
Chemical Science, 13(10), 2985-2991. ROYAL SOC CHEMISTRY
Chemical Science, 13(10), 2985-2991. Royal Society of Chemistry
Chemical Science, 13(10), 2985. Royal Society of Chemistry

The continued rise of antibiotic resistance is a global concern that threatens to undermine many aspects of modern medical practice. Key to addressing this threat is the discovery and development of new antibiotics that operate by unexploited modes o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb2bdb31461631c6d764b8679f4c365
https://hdl.handle.net/11370/60166c24-fb77-483d-9be4-855bf16fcc0e

Mechanistic insights into the C55-P targeting lipopeptide antibiotics revealed by structure–activity studies and high-resolution crystal structures.

Autor: Wood, Thomas M., Zeronian, Matthieu R., Buijs, Ned, Bertheussen, Kristine, Abedian, Hanieh K., Johnson, Aidan V., Pearce, Nicholas M., Lutz, Martin, Kemmink, Johan, Seirsma, Tjalling, Hamoen, Leendert W., Janssen, Bert J. C., Martin, Nathaniel I.

Publikováno v: Chemical Science; 3/14/2022, Vol. 13 Issue 10, p2985-2991, 7p