Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Abed Rahman Kawakibi"'
Autor:
Varun Vijay Prabhu, Sara Morrow, Abed Rahman Kawakibi, Lanlan Zhou, Marie Ralff, Jocelyn Ray, Aakash Jhaveri, Isacco Ferrarini, Young Lee, Cassandra Parker, Yiqun Zhang, Robyn Borsuk, Wen-I Chang, Joshua N. Honeyman, Fabio Tavora, Benedito Carneiro, Alexander Raufi, Kelsey Huntington, Lindsey Carlsen, Anna Louie, Howard Safran, Attila A. Seyhan, Rohinton S. Tarapore, Lee Schalop, Martin Stogniew, Joshua E. Allen, Wolfgang Oster, Wafik S. El-Deiry
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 12, Pp 725-744 (2020)
ONC201 was originally discovered as TNF-Related Apoptosis Inducing Ligand (TRAIL)-inducing compound TIC10. ONC201 appears to act as a selective antagonist of the G protein coupled receptor (GPCR) dopamine receptor D2 (DRD2), and as an allosteric agon
Externí odkaz:
https://doaj.org/article/ab2136215d2b48418947dffdd2998a3e
Autor:
Porag Das, Jacquelyn Miller, Alexandra I. Mansour, Alison S. Baskin, Anthony Cuttitta, Anthony E. Rios, Abed Rahman Kawakibi, Lesly A. Dossett, Hannah Lahti
Publikováno v:
Journal of Surgical Research. 270:359-368
Background For patients undergoing surgery at an Ambulatory Surgical Center, recent changes to Centers for Medicare and Medicaid Services policy allow for the omission of a 30-day preoperative History and Physical (H&P). Preoperative H&Ps for low-ris
Autor:
Abed Rahman Kawakibi, Rohinton Tarapore, Sharon Gardner, Andrew Chi, Sylvia Kurz, Patrick Y Wen, Isabel Arrillaga-Romany, Tracy Batchelor, Nicholas Butowski, Ashley Sumrall, Nicole Shonka, Rebecca Harrison, John DeGroot, Minesh Mehta, Yazmin Odia, Matthew Hall, Doured Daghistani, Timothy Cloughesy, Benjamin Ellingson, Michelle Kim, Yoshie Umemura, Hugh Garton, Andrea Franson, Jonathan Schwartz, Sunjong Li, Rodrigo Cartaxo, Karthik Ravi, Evan Cantor, Jessica Cummings, Alyssa Paul, Dustin Walling, Matthew Dun, Jason Cain, Jiang Li, Mariella Filbin, Lili Zhao, Chandan Kumar-Sinha, Rajen Mody, Arul Chinnaiyan, Ryo Kurokawa, Drew Pratt, Sriram Venneti, Jacques Grill, Cassie Kline, Sabine Mueller, Adam C Resnick, Javad Nazarian, Sebastian Waszak, Joshua E Allen, Carl Koschmann
Publikováno v:
Neuro-Oncology. 24:vii86-vii87
Patients with H3K27M-mutated diffuse midline glioma (DMG) have no proven effective therapies beyond radiation. ONC201, a DRD2 antagonist and mitochondrial ClpP agonist, has shown promise in this population. Clinical and genetic variables associated w
Autor:
Evan Cantor, Kyle Wierzbicki, Rohinton S Tarapore, Karthik Ravi, Chase Thomas, Rodrigo Cartaxo, Viveka Nand Yadav, Ramya Ravindran, Amy K Bruzek, Jack Wadden, Vishal John, Clarissa May Babila, Jessica R Cummings, Abed Rahman Kawakibi, Sunjong Ji, Johanna Ramos, Alyssa Paul, Dustin Walling, Marcia Leonard, Patricia Robertson, Andrea Franson, Rajen Mody, Hugh J L Garton, Sriram Venneti, Yazmin Odia, Cassie Kline, Nicholas A Vitanza, Soumen Khatua, Sabine Mueller, Joshua E Allen, Sharon L Gardner, Carl Koschmann
Publikováno v:
Neuro Oncol
Background Diffuse Midline Glioma (DMG) with the H3K27M mutation is a lethal childhood brain cancer, with patients rarely surviving 2 years from diagnosis. Methods We conducted a multi-site Phase 1 trial of the imipridone ONC201 for children with H3K
Autor:
Marie D. Ralff, Benedito A. Carneiro, Lanlan Zhou, Wen-I Chang, Rohinton Tarapore, Varun V. Prabhu, Joshua N. Honeyman, Attila A. Seyhan, Isacco Ferrarini, Alexander G. Raufi, Lindsey Carlsen, Martin Stogniew, Lee Schalop, Robyn Borsuk, Joshua E. Allen, Aakash Jhaveri, Cassandra Parker, Sara Morrow, Young Lee, Fabio Tavora, Wolfgang Oster, Jocelyn E. Ray, Kelsey E. Huntington, Howard Safran, Anna D Louie, Abed Rahman Kawakibi, Yiqun Zhang, Wafik S. El-Deiry
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 12, Pp 725-744 (2020)
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 12, Pp 725-744 (2020)
ONC201 was originally discovered as TNF-Related Apoptosis Inducing Ligand (TRAIL)-inducing compound TIC10. ONC201 appears to act as a selective antagonist of the G protein coupled receptor (GPCR) dopamine receptor D2 (DRD2), and as an allosteric agon
Autor:
Evan Cantor, Kyle Wierzbicki, Rohinton Tarapore, Karthik Ravi, Jack Wadden, Clarissa Babilla, Chase Thomas, Rodrigo Cartaxo, Vivek Anand Yadav, Ramya Ravindran, Amy K Bruzek, Jessica Cummings, Abed Rahman Kawakibi, Sunjong Ji, Alyssa Paul, Ian Wolfe, Marcia Leonard, Patricia Robertson, Andrea Franson, Rajen Mody, Hugh Garton, Yazmin Odia, Cassie Kline, Nicholas Vitanza, Soumen Khatua, Joshua Allen, Sabine Mueller, Sharon Gardner, Carl Koschmann
Publikováno v:
Neuro-Oncology. 23:vi16-vi17
Diffuse midline glioma (DMG) with H3K27M mutation is a lethal childhood brain cancer, with limited means of monitoring beyond serial MRI scans. We conducted a multi-site Phase 1 trial of the imipridone ONC201 for children with H3K27M-mutant glioma (N
Autor:
Carl Koschmann, Abed Rahman Kawakibi, Rohinton Tarapore, Sharon Gardner, Chase Thomas, Rodrigo Cartaxo, Viveka Yadav, Andrew Chi, Sylvia Kurz, Patrick Wen, Isabel Arrillaga, Tracy Batchelor, Nicholas Butowski, Ashley Sumrall, Nicole Shonka, Rebecca Harrison, John De Groot, Minesh Mehta, Yazmin Odia, Matthew Hall, Doured Daghistani, Timothy Cloughesy, Benjamin Ellingson, Michelle Kim, Yoshie Umemura, Hugh Garton, Andrea Franson, Patricia Robertson, Jonathan Schwartz, Bernard Marini, Manjunath Pai, Timothy Phoenix, Sunjong Ji, Evan Cantor, Zachary Miklja, Brendan Mullan, Amy Bruzek, Ruby Siada, Jessica Cummings, Stefanie Stallard, Kyle Wierzbicki, Alyssa Paul, Ian Wolfe, Matthew Dun, Jason Cain, Li Jiang, Mariella Filbin, Pankaj Vats, Chandan Kumar-Sinha, Rajen Mody, Arul Chinnaiyan, Drew Pratt, Sriram Venneti, Guangrong Lu, Sabine Mueller, Adam Resnick, Javad Nazarian, Sebastian Waszak, Joshua Allen
Patients with diffuse midline glioma (DMG) harboring H3 K27M mutation have no proven therapies beyond radiation. ONC201, a DRD2 antagonist and mitochondrial ClpP agonist, has induced early responses in patients with H3 K27M-mutant DMG. We performed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06f1acf7b9e4e63c9e411b7056b9a949
https://doi.org/10.21203/rs.3.rs-69706/v1
https://doi.org/10.21203/rs.3.rs-69706/v1
Autor:
Micah K Harris, Evan Cantor, Amy K. Bruzek, Bernard L. Marini, Carl Koschmann, Morgan J Homan, Andrea Franson, Abed Rahman Kawakibi, Ramya Ravindran, Viveka Nand Yadav, Kyle Wierzbicki, Karthik Ravi, Rodrigo Teodoro
Publikováno v:
Current Oncology Reports. 22
The original version of this review article unfortunately contained a mistake in the author group section.
Autor:
Bernard L. Marini, Amy K. Bruzek, Kyle Wierzbicki, Carl Koschmann, Andrea Franson, Rodrigo Teodoro, Ramya Ravindran, Karthik Ravi, Evan Cantor, Morgan J Homan, Abed Rahman Kawakibi, Micah K Harris, Viveka Nand Yadav
Publikováno v:
Curr Oncol Rep
PURPOSE OF REVIEW: H3K27M is a frequent histone mutation within diffuse midline gliomas and is associated with a dismal prognosis, so much so that the 2016 CNS WHO classification system created a specific category of “Diffuse Midline Glioma, H3K27M
Autor:
Cyril H. Benes, Sharon DeMorrow, Varun V. Prabhu, Robert J. Wechsler-Reya, Ultan McDermott, Olivier Elemento, Martin Stogniew, Joshua E. Allen, Abed Rahman Kawakibi, Mathew J. Garnett, Wolfgang Oster, Neel Madhukar
Publikováno v:
Neuro Oncol
ONC201 is the first clinical bitopic antagonist of DRD2, an oncogenic receptor in brain and neuroendocrine tumors. ONC206, a derivative of ONC201 that shares the imipridone core structure, is also a bitopic DRD2 antagonist that exhibits enhanced non-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1108e97b52d2953f575711ea823d39
https://europepmc.org/articles/PMC6846353/
https://europepmc.org/articles/PMC6846353/