An enveloped virus-like particle vaccine expressing a stabilized prefusion form of the SARS-CoV-2 spike protein elicits highly potent immunity

Autor: Jasminka Bozic, Anh Tran, Catalina Soare, Barthelemy Ontsouka, Anne-Catherine Fluckiger, Tanvir Ahmed, Mingmin Liao, Diane Duque, Francisco Diaz-Mitoma, David E. Anderson, Michael J McCluskie, Abebaw Diress, Tamara Berthoud

Publikováno v: Vaccine

We evaluated enveloped virus-like particles (eVLPs) expressing various forms of the Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike protein and several adjuvants in an effort to identify a highly potent Coronavirus disease 2019 (CO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7526a6ca9c17abf64e6433749bc9a881
https://nrc-publications.canada.ca/eng/view/object/?id=8d80f04e-c26e-4ce5-b693-2e491570db49

ENVELOPED VIRUS-LIKE PARTICLES (eVLPs) EXPRESSING MODIFIED FORMS OF ZIKA VIRUS PROTEINS E AND NS1 PROTECT MICE FROM ZIKA VIRUS INFECTION

Autor: Jasminka Bozic, Conlan W, Catalina Soare, Ponce A, M. Kirchmeier, Anne-Catherine Fluckiger, Abebaw Diress, Francisco Diaz-Mitoma, Barthelemy Ontsouka, David E. Anderson, Tanvir Ahmed

While Zika virus (ZIKV) infection induces mild disease in the majority of cases, it has been identified as responsible for microcephaly and severe neurological disorders in recent 2015-2016 outbreaks in South America and the Caribbean. Since then, se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9889c00d88668dfaba3b60ff311f811
https://doi.org/10.1101/666966

Study of aggregation, denaturation and reduction of interferon alpha-2 products by size-exclusion high-performance liquid chromatography with fluorescence detection and biological assays

Autor: Abebaw Diress, Xuguang Li, Louise Larocque, Richard Isbrucker, Barry Lorbetskie, Michel Girard, Matthew Alteen

Publikováno v: Journal of Chromatography A. 1217:3297-3306

Interferon alpha-2 (IFN alpha-2) products have been widely used as antivirals for the treatment of serious diseases such as hepatitis B and C. However, reports of adverse reactions following treatment have prompted investigations into the cause of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991e7340cdc71cced8df409c2e70a88c
https://doi.org/10.1016/j.chroma.2009.10.081

Enveloped virus-like particle expression of human cytomegalovirus glycoprotein B antigen induces antibodies with potent and broad neutralizing activity

Autor: Stanley A. Plotkin, Anne-Catherine Fluckiger, David Klatzmann, Lenore Pereira, Charlotte Dalba, Barthelemy Ontsouka, Tanvir Ahmed, David E. Anderson, Marc Kirchmeier, Abebaw Diress, Jasminka Bozic, Florian Schödel, Catalina Soare

Publikováno v: Kirchmeier, M; Fluckiger, AC; Soare, C; Bozic, J; Ontsouka, B; Ahmed, T; et al.(2014). Enveloped virus-like particle expression of human cytomegalovirus glycoprotein B antigen induces antibodies with potent and broad neutralizing activity. Clinical and Vaccine Immunology, 21(2), 174-180. doi: 10.1128/CVI.00662-13. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/73q2w2j9
Clinical and vaccine immunology : CVI, vol 21, iss 2

A prophylactic vaccine to prevent the congenital transmission of human cytomegalovirus (HCMV) in newborns and to reduce life-threatening disease in immunosuppressed recipients of HCMV-infected solid organ transplants is highly desirable. Neutralizing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::263886c0ddadbf92d88d8af5b9cc8a01
http://www.escholarship.org/uc/item/73q2w2j9

Bioactivity Determination of Native and Variant Forms of Therapeutic Interferons

Autor: Runtao He, Louise Larocque, Michel Girard, Abebaw Diress, Alex Bliu, Xuguang Li, Ranran Xu, Rongtuan Lin, Junzhi Wang

Publikováno v: Journal of Biomedicine and Biotechnology
Journal of Biomedicine and Biotechnology, Vol 2011 (2011)

The traditional antiviral assays for the determination of interferon potency are reported to have considerable variability between and within assays. Although several reporter gene assays based on interferon-inducible promoter activities have been re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c4fbfac16de2864fd3d921c1f74753
http://europepmc.org/articles/PMC3051158