Hyperammonaemia induces mitochondrial dysfunction and neuronal cell death

Autor: Plamena R. Angelova, Annarein J.C. Kerbert, Abeba Habtesion, Andrew Hall, Andrey Y. Abramov, Rajiv Jalan

Publikováno v: JHEP Reports, Vol 4, Iss 8, Pp 100510- (2022)

Background & Aims: In cirrhosis, astrocytic swelling is believed to be the principal mechanism of ammonia neurotoxicity leading to hepatic encephalopathy (HE). The role of neuronal dysfunction in HE is not clear. We aimed to explore the impact of hyp

Externí odkaz: https://doaj.org/article/3dd4c18ff4954ee1b0ec660b75bea25c

The Lipopolysaccharide-Sensing Caspase(s)-4/11 Are Activated in Cirrhosis and Are Causally Associated With Progression to Multi-Organ Injury

Autor: Ugo Soffientini, Nigel Beaton, Sukriti Baweja, Emmanuel Weiss, Chhagan Bihari, Abeba Habtesion, Vishal Patel, Valerie Paradis, Archana Sharma, Tu Vinh Luong, Andrew Hall, Aida Nadar, Shiv Sarin, Shilpa Chokshi, Roger Williams, Benedicte Py, Richard Moreau, Rajiv Jalan, Gautam Mehta

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Background and AimsThe development of multi-organ injury in cirrhosis is associated with increased intestinal permeability, translocation of gut-derived bacterial products [e.g., lipopolysaccharide (LPS)] into the circulation, and increased non-apopt

Externí odkaz: https://doaj.org/article/57a35ab6ce234be49771b0d60ea019f8

Combination of G-CSF and a TLR4 inhibitor reduce inflammation and promote regeneration in a mouse model of ACLF

Autor: Cornelius Engelmann, Abeba Habtesion, Mohsin Hassan, Annarein JC. Kerbert, Linda Hammerich, Simone Novelli, Marco Fidaleo, Alexandra Philips, Nathan Davies, Sofia Ferreira-Gonzalez, Stuart J. Forbes, Thomas Berg, Fausto Andreola, Rajiv Jalan

Publikováno v: Engelmann, C, Habtesion, A, Hassan, M, Kerbert, A JC, Hammerich, L, Novelli, S, Fidaleo, M, Philips, A, Davies, N, Ferreira-Gonzalez, S, Forbes, S J, Berg, T, Andreola, F & Jalan, R 2022, ' Combination of G-CSF and a TLR4 inhibitor reduce inflammation and promote regeneration in a mouse model of ACLF ', Journal of Hepatology, vol. 77, no. 5, pp. 1325-1338 . https://doi.org/10.1016/j.jhep.2022.07.006
Journal Hepathology

Background & Aims: Acute-on-chronic liver failure (ACLF) is characterised by high short-term mortality, systemic inflammation, and failure of hepatic regeneration. Its treatment is a major unmet medical need. This study was conducted to explore wheth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50997bbb1d2e7489e82625d1f4f96ff7
https://hdl.handle.net/20.500.11820/4c3ed0e6-23ac-4d92-9332-33beb91bd906

Long-term albumin administration improves survival, reduces TLR4 mediated hepatic inflammation and reduces gut translocation in models of cirrhosis

Autor: Alexandra Phillips, Qianwen Zhao, Abeba Habtesion, Fausto Andreola, Nathan Davies, Lindsey A Edwards, Jane Macnaughtan, Rajiv Jalan

Publikováno v: Journal of Hepatology. 77:S366

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc80ae1342f4370b55948cb48642ee2b
https://doi.org/10.1016/s0168-8278(22)01085-6

Inhibition of toll-like receptor 4 signaling reduces hyperammonemia by modulating urea cycle function

Autor: Annarein Kerbert, Cornelius Engelmann, Yalda Sharifi, Abeba Habtesion, Fausto Andreola, Rajiv Jalan

Publikováno v: Journal of Hepatology. 73:S206

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::387f95d6b33a901633bbfc8237961b58
https://doi.org/10.1016/s0168-8278(20)30920-x