Výsledky vyhledávání - "Abdulraouf M Abbas"

Lymph node-targeted vaccine boosting of TCR-T cell therapy enhances anti-tumor function and eradicates solid tumors

Autor: Dylan J. Drakes, Abdulraouf M. Abbas, Jacqueline Shields, Martin P. Steinbuck, Aniela Jakubowski, Lochana M. Seenappa, Christopher M. Haqq, Peter C. DeMuth

While T cell receptor (TCR)-modified T cell therapies have shown promise against solid tumors, overall therapeutic benefits in clinical practice have been modest due in part to suboptimal T cell persistence and activation in vivo, alongside the possi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c75470b10dcf0ff3789539378b3fae3d
https://doi.org/10.1101/2022.05.05.490779

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ERAP1 deficient mice have reduced Type 1 regulatory T cells and develop skeletal and intestinal features of Ankylosing Spondylitis

Autor: Patrick O'Connell, Maja K. Blake, Yasser A. Aldhamen, Ariana M Angarita, Fadel S. Alyaqoub, David P W Rastall, Yuliya Pepelyayeva, Sarah G Roosa, Cristiane Pereira-Hicks, Sandra Raehtz, Laura R. McCabe, Abdulraouf M Abbas, Ashley M Raedy, Andrea Amalfitano

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)

Ankylosing spondylitis (AS) is a prototypical sero-negative autoimmune disease that affects millions worldwide. Single nucleotide polymorphisms in the Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) gene have been linked to AS via GWAS studies, howeve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0e8724e7434906218866cf65bbc7e0
https://doi.org/10.1038/s41598-018-30159-5

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Abstract 2994: Engineered STING-targeting immunotherapy delays B16 melanoma tumor growth and significantly improves animal survival as compared to an immune-checkpoint inhibitor

Autor: Fadel S. Alyaqoub, Andrea Amalfitano, Yasser A. Aldhamen, Abdulraouf M Abbas, Cristiane Pereira-Hicks, Sarah Godbehere, Christopher M. Waters

Publikováno v: Cancer Research. 77:2994-2994

Background: The stimulator of interferon genes (STING) is a cytosolic innate sensor activated by cyclic di-nucleotides (CDNs) including the bacterially derived bis-(3′-5′)-cyclic-dimeric-guanosine monophosphate (c-di-GMP), leading to the inductio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ccb24678d3c80abc27d02de840ebf87
https://doi.org/10.1158/1538-7445.am2017-2994

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