Loss of the tumor suppressor BIN1 enables ATM Ser/Thr kinase activation by the nuclear protein E2F1 and renders cancer cells resistant to cisplatin.

Autor: Folk WP; From the Biochemistry and Cancer Biology Graduate Program, Augusta University, Augusta, Georgia 30912.; the Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.; the Tumor Signaling and Angiogenesis Program, Georgia Cancer Center, Augusta University, Augusta, Georgia 30912., Kumari A; the Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.; the Tumor Signaling and Angiogenesis Program, Georgia Cancer Center, Augusta University, Augusta, Georgia 30912., Iwasaki T; the Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.; the Tumor Signaling and Angiogenesis Program, Georgia Cancer Center, Augusta University, Augusta, Georgia 30912.; the Division of Signal Pathways, Biosignal Research Center, Kobe University, Kobe 657, Japan., Pyndiah S; the Molecular Signaling Program, Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112., Johnson JC; the Medicinal Chemistry and Molecular Pharmacology Graduate Program, Purdue University, West Lafayette, Indiana 47907, and., Cassimere EK; the Molecular Signaling Program, Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112.; the Medicinal Chemistry and Molecular Pharmacology Graduate Program, Purdue University, West Lafayette, Indiana 47907, and., Abdulovic-Cui AL; the Department of Biological Sciences, College of Science and Mathematics, Augusta University, Augusta, Georgia 30904., Sakamuro D; From the Biochemistry and Cancer Biology Graduate Program, Augusta University, Augusta, Georgia 30912, dsakamuro@augusta.edu.; the Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, Georgia 30912.; the Tumor Signaling and Angiogenesis Program, Georgia Cancer Center, Augusta University, Augusta, Georgia 30912.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2019 Apr 05; Vol. 294 (14), pp. 5700-5719. Date of Electronic Publication: 2019 Feb 07.