Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Abdullah O. Khan"'
Autor:
Jasmeet S. Reyat, Alessandro di Maio, Beata Grygielska, Jeremy Pike, Samuel Kemble, Antonio Rodriguez-Romero, Christina Simoglou Karali, Adam P. Croft, Bethan Psaila, Filipa Simões, Julie Rayes, Abdullah O. Khan
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
IntroductionRecent advances in human cardiac 3D approaches have yielded progressively more complex and physiologically relevant culture systems. However, their application in the study of complex pathological processes, such as inflammation and fibro
Externí odkaz:
https://doaj.org/article/3399289f4d04440a98842fe8c911f425
Autor:
Olga Krysko, Joshua H. Bourne, Elena Kondakova, Elena A. Galova, Katharine Whitworth, Maddy L. Newby, Claus Bachert, Harriet Hill, Max Crispin, Zania Stamataki, Adam F. Cunningham, Matthew Pugh, Abdullah O. Khan, Julie Rayes, Maria Vedunova, Dmitri V. Krysko, Alexander Brill
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundThe systemic inflammatory response post-SARS-CoV-2 infection increases pro-inflammatory cytokine production, multi-organ damage, and mortality rates. Mast cells (MC) modulate thrombo-inflammatory disease progression (e.g., deep vein thrombo
Externí odkaz:
https://doaj.org/article/79b67959ef144c44ab258fd04a23bccb
Autor:
Jeremy A. Pike, Victoria A. Simms, Christopher W. Smith, Neil V. Morgan, Abdullah O. Khan, Natalie S. Poulter, Iain B. Styles, Steven G. Thomas
Publikováno v:
Platelets, Vol 32, Iss 1, Pp 54-58 (2021)
The assessment of platelet spreading through light microscopy, and the subsequent quantification of parameters such as surface area and circularity, is a key assay for many platelet biologists. Here we present an analysis workflow which robustly segm
Externí odkaz:
https://doaj.org/article/222a62998c644c59bb42c5bc19d835a7
Autor:
Abdullah O. Khan, Jeremy A. Pike
Publikováno v:
Platelets, Vol 31, Iss 5, Pp 559-569 (2020)
Recent advances in super-resolution (sub-diffraction limited) microscopy have yielded remarkable insights into the nanoscale architecture and behavior of cells. In addition to the capacity to provide sub 100 nm resolution, these technologies offer un
Externí odkaz:
https://doaj.org/article/a9ad916bdd9a45b7b8501d3f6156706a
Autor:
Joanne Lacey, Simon J. Webster, Paul R. Heath, Chris J. Hill, Lucinda Nicholson-Goult, Bart E. Wagner, Abdullah O. Khan, Neil V. Morgan, Michael Makris, Martina E. Daly
Publikováno v:
Haematologica, Vol 107, Iss 8 (2022)
Germline defects affecting the DNA-binding domain of the transcription factor FLI1 are associated with a bleeding disorder that is characterized by the presence of large, fused α-granules in platelets. We investigated whether the genes showing abnor
Externí odkaz:
https://doaj.org/article/5e8049395ae1492595e078a91e38c33b
Autor:
Waltraud C. Schrottmaier, Anita Pirabe, David Pereyra, Stefan Heber, Hubert Hackl, Anna Schmuckenschlager, Laura Brunnthaler, Jonas Santol, Kerstin Kammerer, Justin Oosterlee, Erich Pawelka, Sonja M. Treiber, Abdullah O. Khan, Matthew Pugh, Marianna T. Traugott, Christian Schörgenhofer, Tamara Seitz, Mario Karolyi, Bernd Jilma, Julie Rayes, Alexander Zoufaly, Alice Assinger
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2022)
Coronavirus disease 2019 (COVID-19) induces a hypercoagulatory state that frequently leads to thromboembolic complications. Whereas anticoagulation is associated with reduced mortality, the role of antiplatelet therapy in COVID-19 is less clear. We r
Externí odkaz:
https://doaj.org/article/aa45ea165912461dbabdad4a74abcca7
Autor:
Waltraud C. Schrottmaier, Anita Pirabe, David Pereyra, Stefan Heber, Hubert Hackl, Anna Schmuckenschlager, Laura Brunnthaler, Jonas Santol, Kerstin Kammerer, Justin Oosterlee, Erich Pawelka, Sonja M. Treiber, Abdullah O. Khan, Matthew Pugh, Marianna T. Traugott, Christian Schörgenhofer, Tamara Seitz, Mario Karolyi, Bernd Jilma, Julie Rayes, Alexander Zoufaly, Alice Assinger
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Thromboembolic complications are frequently observed in Coronavirus disease 2019 (COVID-19). While COVID-19 is linked to platelet dysregulation, the association between disease outcome and platelet function is less clear. We prospectively monitored p
Externí odkaz:
https://doaj.org/article/95669424e98c45f4b6455fb6feb38854
Autor:
Abdullah O. Khan, Alexandre Slater, Annabel Maclachlan, Phillip L.R. Nicolson, Jeremy A. Pike, Jasmeet S. Reyat, Jack Yule, Rachel Stapley, Julie Rayes, Steven G. Thomas, Neil V. Morgan
Publikováno v:
Haematologica, Vol 107, Iss 1 (2020)
In specialized cells, the expression of specific tubulin isoforms and their subsequent post-translational modifications drive and coordinate unique morphologies and behaviors. The mechanisms by which β1-tubulin, the platelet and megakaryocyte (MK) l
Externí odkaz:
https://doaj.org/article/499818eef52141fda25ba5aa4841cfc0
Autor:
Abdullah O. Khan, Annabel Maclachlan, Gillian C. Lowe, Phillip L.R. Nicolson, Rashid Al Ghaithi, Steven G. Thomas, Steve P. Watson, Jeremy A. Pike, Neil V. Morgan
Publikováno v:
Haematologica, Vol 105, Iss 3 (2020)
Externí odkaz:
https://doaj.org/article/841b56189aed4bee91ddf86401a6496e
Autor:
Phillip L.R. Nicolson, Sophie H. Nock, Joshua Hinds, Lourdes Garcia-Quintanilla, Christopher W. Smith, Joana Campos, Alexander Brill, Jeremy A. Pike, Abdullah O. Khan, Natalie S. Poulter, Diedre M. Kavanagh, Stephanie Watson, Callum N. Watson, Hayley Clifford, Aarnoud P. Huissoon, Alice Y. Pollitt, Johannes A. Eble, Guy Pratt, Steve P. Watson, Craig E. Hughes
Publikováno v:
Haematologica, Vol 106, Iss 1 (2020)
Inhibitors of the tyrosine kinase Btk have been proposed as novel antiplatelet agents. In this study we show that low concentrations of the Btk inhibitor ibrutinib block CLEC-2-mediated activation and tyrosine phosphorylation including Syk and PLCγ2
Externí odkaz:
https://doaj.org/article/488fe4d4fc05448a940504d50e98e98e