Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Abdullah Allaoa"'
Autor:
Rajendra Uprety, Tao Che, Saheem A Zaidi, Steven G Grinnell, Balázs R Varga, Abdelfattah Faouzi, Samuel T Slocum, Abdullah Allaoa, András Varadi, Melissa Nelson, Sarah M Bernhard, Elizaveta Kulko, Valerie Le Rouzic, Shainnel O Eans, Chloe A Simons, Amanda Hunkele, Joan Subrath, Ying Xian Pan, Jonathan A Javitch, Jay P McLaughlin, Bryan L Roth, Gavril W Pasternak, Vsevolod Katritch, Susruta Majumdar
Publikováno v:
eLife, Vol 10 (2021)
Controlling receptor functional selectivity profiles for opioid receptors is a promising approach for discovering safer analgesics; however, the structural determinants conferring functional selectivity are not well understood. Here, we used crystal
Externí odkaz:
https://doaj.org/article/dc31183697a3454e95268139bbe3d9fd
Autor:
Bronwyn M. Kivell, Shainnel O. Eans, Abdullah Allaoa, András Váradi, Lisa L. Wilson, Gavril W. Pasternak, Rajendra Uprety, Andrew C. Kruegel, John E. Pintar, Xiaohai Li, Samuel T. Slocum, Takeshi Irie, Jay P. McLaughlin, Brittany Scouller, Amy F. Alder, Michael D. Cameron, Sanjay Kalra, Ying-Xian Pan, Amanda Hunkele, Susruta Majumdar, Michael Ansonoff, Valerie Le Rouzic, Dalibor Sames, Soumen Chakraborty, Jin Xu
Publikováno v:
J Med Chem
The leaves of Mitragyna speciosa (kratom), a plant native to Southeast Asia, are increasingly used as a pain reliever and for attenuation of opioid withdrawal symptoms. Using the tools of natural products chemistry, chemical synthesis, and pharmacolo
Autor:
Abdelfattah Faouzi, Hye Jean Yoon, Rajendra Uprety, John M. Streicher, Lakshmi A. Devi, Susruta Majumdar, Michael Ansonoff, Ivone Gomes, Nicolas Massaly, Tiffany Zhang, Valerie Le Rouzic, Attila Keresztes, Jose A. Morón, Ying-Xian Pan, Achla Gupta, Abdullah Allaoa, John E. Pintar
Publikováno v:
J Med Chem
In this work, we studied a series of carfentanyl amide-based opioid derivatives targeting the mu opioid receptor (μOR) and the delta opioid receptor (δOR) heteromer as a credible novel target in pain management therapy. We identified a lead compoun
Autor:
Alex C. Ferris, Rajendra Uprety, Susruta Majumdar, Gavril W. Pasternak, Vijay S. Pande, Evan N. Feinberg, Gabriel N. Redel-Traub, Abdullah Allaoa, Travis C. Palmer, András Váradi
Publikováno v:
European Journal of Medicinal Chemistry. 164:241-251
A library-friendly approach to generate new scaffolds is decisive for the development of molecular probes, drug like molecules and preclinical entities. Here, we present the design and synthesis of novel heterocycles with spiro-2,6-dioxopiperazine an
Autor:
Samuel T. Slocum, Vsevolod Katritch, Rajendra Uprety, Joan J. Subrath, Jay P. McLaughlin, Gavril W. Pasternak, Ying Xian Pan, Amanda Hunkele, Valerie Le Rouzic, Melissa Nelson, Steven G. Grinnell, Abdelfattah Faouzi, András Váradi, Saheem A. Zaidi, Bryan L. Roth, Shainnel O. Eans, Balázs Varga, Elizaveta Kulko, Abdullah Allaoa, Tao Che, Susruta Majumdar, Sarah M Bernhard, Jonathan A. Javitch, Chloe A. Simons
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Controlling receptor functional selectivity profiles for opioid receptors is a promising approach for discovering safer analgesics; however, the structural determinants conferring functional selectivity are not well understood. Here, we used crystal
Autor:
Gavril W. Pasternak, Abdelfattah Faouzi, Bryan L. Roth, Amanda Hunkele, Steven G. Grinnell, Susruta Majumdar, Valerie Le Rouzic, Melissa Nelson, Sarah M Bernhard, Chloe A. Simons, Shainnel O. Eans, Samuel T. Slocum, Rajendra Uprety, Joan J. Subrath, András Váradi, Tao Che, Ying Xian Pan, Jonathan A. Javitch, Elizaveta Kulko, Vsevolod Katritch, Abdullah Allaoa, Saheem A. Zaidi, Balázs Varga, Jay P. McLaughlin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acf306e63c447f91f658560d8a55c64b
https://doi.org/10.7554/elife.56519.sa2
https://doi.org/10.7554/elife.56519.sa2
Autor:
Rajendra, Uprety, András, Váradi, Abdullah, Allaoa, Gabriel N, Redel-Traub, Travis C, Palmer, Evan N, Feinberg, Alex C, Ferris, Vijay S, Pande, Gavril W, Pasternak, Susruta, Majumdar
Publikováno v:
European journal of medicinal chemistry. 164
A library-friendly approach to generate new scaffolds is decisive for the development of molecular probes, drug like molecules and preclinical entities. Here, we present the design and synthesis of novel heterocycles with spiro-2,6-dioxopiperazine an