Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Abdullah A. Alshudukhi"'
Autor:
Abdulrahman Jama, Abdullah A. Alshudukhi, Steve Burke, Lixin Dong, John Karanja Kamau, Brooklyn Morris, Ibrahim A. Alkhomsi, Brian N. Finck, Andrew Alvin Voss, Hongmei Ren
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background Duchenne muscular dystrophy (DMD) is a progressive and devastating muscle disease, resulting from the absence of dystrophin. This leads to cell membrane instability, susceptibility to contraction-induced muscle damage, subsequent
Externí odkaz:
https://doaj.org/article/e1d4da805e9b453fa9ff3ce6ee88fb29
Autor:
Sandhya Ramani Sattiraju, Abdulrahman Jama, Abdullah A. Alshudukhi, Nicholas Edward Townsend, Daniel Reynold Miranda, Rebecca R Reese, Andrew A. Voss, Hongmei Ren
Publikováno v:
Physiological Reports, Vol 8, Iss 20, Pp n/a-n/a (2020)
Abstract Mutations in lipin1 are suggested to be a common cause of massive rhabdomyolysis episodes in children; however, the molecular mechanisms involved in the regulation of myofiber death caused by the absence of lipin1 are not fully understood. L
Externí odkaz:
https://doaj.org/article/92233ddff242487596a705e98a099c9c
Muscular dystrophies are inherited disorders that are characterized by progressive muscle degeneration. These disorders are caused by mutation in the genes encoding structural elements within the muscle, which leads to increased vulnerability to mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61d7ef7e147655cc0a51622b79bcc7ab
https://doi.org/10.21203/rs.3.rs-2167571/v1
https://doi.org/10.21203/rs.3.rs-2167571/v1
Publikováno v:
The Journal of Physiology. 597:889-901
KEY POINTS: Lipin1 is critical for skeletal muscle development. Lipin1 regulates MyoD and myocyte‐specific enhancer factor 2C (MEF2c) expression via the protein kinase C (PKC)/histone deacetylase 5‐mediated pathway. Inhibition of PKCμ activity s
Autor:
Nicholas Edward Townsend, Sandhya Ramani Sattiraju, Andrew A. Voss, Daniel R. Miranda, Rebecca R Reese, Abdullah A. Alshudukhi, Abdulrahman Jama, Hongmei Ren
Publikováno v:
Physiological Reports, Vol 8, Iss 20, Pp n/a-n/a (2020)
Physiological Reports
Physiological Reports
Mutations in lipin1 are suggested to be a common cause of massive rhabdomyolysis episodes in children; however, the molecular mechanisms involved in the regulation of myofiber death caused by the absence of lipin1 are not fully understood. Loss of me
Autor:
Abdullah A. Alshudukhi, Jeffrey D. Smith, Karyn A. Esser, Jing Zhu, Abdulrahman Jama, Hongmei Ren, Dengtong Huang, Qing Jun Wang
Publikováno v:
The FASEB Journal. 32:6796-6807
Autophagy of mitochondria (mitophagy) is essential for maintaining muscle mass and healthy skeletal muscle. Patients with heritable phosphatidic acid phosphatase lipin-1–null mutations present with severe rhabdomyolysis and muscle atrophy in glycol