Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Abdulbaqi AlKawaz"'
Autor:
Emad A. Rakha, Michael S. Toss, Abdulbaqi AlKawaz, Reem Ali, Andrew R. Green, Srinivasan Madhusudan, Omar J. Mohammed, Islam M. Miligy
Publikováno v:
Breast Cancer Research and Treatment
Background The prediction of clinical behaviour of breast ductal carcinoma in situ (DCIS) and its progression to invasive disease remains a challenge. Alterations of DNA damage repair mechanisms are associated with invasive breast cancer (BC). This s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4536e467a7de4a317ec30b26f507d17
http://europepmc.org/articles/PMC8557137
http://europepmc.org/articles/PMC8557137
Autor:
Emad A. Rakha, Omar J. Mohammed, Islam M. Miligy, Andrew R. Green, Abdulbaqi AlKawaz, Michael S. Toss, Srinivasan Madhusudan
Publikováno v:
Breast Cancer Research and Treatment
BackgroundImpaired DNA repair mechanism is one of the cancer hallmarks. Flap Endonuclease 1 (FEN1) is essential for genomic integrity. FEN1 has key roles during base excision repair (BER) and replication. We hypothesised a role for FEN1 in breast can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::087ccabae8125904e52140b16dbcb558
Autor:
Andrew R. Green, Ian O. Ellis, Asima Abidi, Luke McCaffrey, Kylie L. Gorringe, Islam M. Miligy, Michael S. Toss, Emad A. Rakha, Abdulbaqi AlKawaz
Publikováno v:
Modern Pathology. 32:639-649
Legumain is a proteolytic enzyme that plays a role in the regulation of cell proliferation in invasive breast cancer. Studies evaluating its role in ductal carcinoma in situ (DCIS) are lacking. Here, we aimed to characterize legumain protein expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9c18b7a18ec8e861f077824461cdd3
https://doi.org/10.1038/s41379-018-0180-x
https://doi.org/10.1038/s41379-018-0180-x
Autor:
Emad A. Rakha, Reem Ali, Katia A. Mesquita, Srinivasan Madhusudan, Sameer Mirza, Islam M. Miligy, Abdulbaqi AlKawaz, Michael S. Toss, Andrew R. Green, Vimla Band, Claire Seedhouse
Publikováno v:
Cancer Research. 78:6818-6827
Targeting PARP1 for synthetic lethality is a new strategy for breast cancers harboring germline mutations in BRCA. However, these mutations are rare, and reactivation of BRCA-mediated pathways may result in eventual resistance to PARP1 inhibitor ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3379d26f8281c54ea9ffa5e364b602c7
https://doi.org/10.1158/0008-5472.can-18-0633
https://doi.org/10.1158/0008-5472.can-18-0633
Autor:
Abdulbaqi AlKawaz, Peter T. Simpson, Kylie L. Gorringe, Islam M. Miligy, Andrew R. Green, Maria Diez-Rodriguez, Christopher C. Nolan, Ian O. Ellis, Michael S. Toss, Emad A. Rakha
Publikováno v:
Modern Pathology. 31:1807-1815
Current clinicopathological parameters are useful predictors of breast ductal carcinoma in situ behavior, but they are insufficient to define high-risk patients for disease progression precisely. Thioredoxin-interacting protein (TXNIP) is a key playe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42c5f740092c8d37386a49d9f39593d
https://doi.org/10.1038/s41379-018-0086-7
https://doi.org/10.1038/s41379-018-0086-7
Autor:
Islam M. Miligy, Abdulbaqi AlKawaz, Emad A. Rakha, Ian O. Ellis, Hazem Khout, Michael S. Toss, Kylie L. Gorringe, Andrew R. Green
Publikováno v:
British Journal of Cancer
Background Extracellular matrix (ECM) plays a crucial role in tumour behaviour. Prolyl-4-hydroxlase-A2 (P4HA2) is a key enzyme in ECM remodelling. This study aims to evaluate the prognostic significance of P4HA2 in breast ductal carcinoma in situ (DC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9cf4bd87fb865c23b79d1ae47dd168
https://doi.org/10.1038/s41416-018-0337-x
https://doi.org/10.1038/s41416-018-0337-x
Autor:
Emad A. Rakha, Abdulbaqi AlKawaz, Ioannis Roxanis, Ritu Aneja, Michael S. Toss, Ian O. Ellis, Islam M. Miligy, Andrew R. Green, Karuna Mittal, Kylie L. Gorringe
Publikováno v:
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 32(10)
Collagen plays a key role in normal and malignant tissue homeostasis. While the prognostic significance of collagen fiber remodeling in invasive breast cancer has been studied, its role in ductal carcinoma in situ (DCIS) remains poorly defined. Using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::841e076df536326f0f5acc77d957cff2
https://pubmed.ncbi.nlm.nih.gov/31175326
https://pubmed.ncbi.nlm.nih.gov/31175326
Autor:
Ritu Aneja, Emad A. Rakha, Abdulbaqi AlKawaz, Andrew R. Green, Michael S. Toss, Mohammed A. Aleskandarany, Islam M. Miligy, Karuna Mittal, Kylie L. Gorringe, Ian O. Ellis
Publikováno v:
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 32(10)
Collagen11A1 (COL11A1) is a fibrillary type collagen constituting a minor component of the extracellular matrix and plays role in tissue tensile strength. Overexpression of COL11A1 expression is associated with aggressive behavior and poor outcome in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00bdf61b8dec310a7158329f767a870
https://pubmed.ncbi.nlm.nih.gov/31175327
https://pubmed.ncbi.nlm.nih.gov/31175327
Autor:
Emad A. Rakha, Karuna Mittal, Kylie L. Gorringe, Rita Haj-Ahmad, Islam M. Miligy, Michael S. Toss, Andrew R. Green, Abdulbaqi AlKawaz, Ian O. Ellis
Publikováno v:
Histopathology. 74(7)
AIMS Cathepsin A (CTSA) is a key regulatory enzyme for galactoside metabolism. Additionally, it has a distinct proteolytic activity and plays a role in tumour progression. CTSA is differentially expressed at the mRNA level between breast ductal carci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa64f205ee1ede8f7cd479b7b1bc977
https://pubmed.ncbi.nlm.nih.gov/30725481
https://pubmed.ncbi.nlm.nih.gov/30725481
Autor:
Sameer Mirza, Andrew R. Green, Michael S. Toss, Abdulbaqi AlKawaz, Emad A. Rakha, Reem Ali, Claire Seedhouse, K. Almeida Mesquita, Srinivasan Madhusudan, I.A. Miligy
Publikováno v:
ESMO Open. 3:A26
Introduction Targeting PARP1 for synthetic lethality is a novel strategy for BRCA germ-line mutated breast cancers. However, BRCA germ-line mutations are rare and reactivation of BRCA mediated pathways may result in eventual resistance to PARP1 inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08753885fb119b9b8e179168ee85a172
https://doi.org/10.1136/esmoopen-2018-eacr25.59
https://doi.org/10.1136/esmoopen-2018-eacr25.59