Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Abdul-rizaq Hamoud"'
Autor:
Abdul-rizaq Hamoud, Khaled Alganem, Sean Hanna, Michael Morran, Nicholas Henkel, Ali S. Imami, William Ryan, Smita Sahay, Priyanka Pulvender, Austin Kunch, Taylen O. Arvay, Jarek Meller, Rammohan Shukla, Sinead M. O’Donovan, Robert McCullumsmith
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Protein kinases are critical components of a myriad biological processes and strongly associated with various diseases. While kinase research has been a point of focus in biomedical research for several decades, a large portion of the kinome
Externí odkaz:
https://doaj.org/article/0fe77c7a32824f5db32b05dec26eb13a
Publikováno v:
Brain Sciences, Vol 14, Iss 7, p 649 (2024)
Gene expression alterations in postmortem schizophrenia tissue are well-documented and are influenced by genetic, medication, and epigenetic factors. The Wingless/Integrated (WNT) signaling pathway, critical for cell growth and development, is involv
Externí odkaz:
https://doaj.org/article/6a2c5fce52374b8f9f7e0a03cb86996c
Autor:
Xiaolu Zhang, Alyssa Wolfinger, Xiaojun Wu, Rawan Alnafisah, Ali Imami, Abdul-rizaq Hamoud, Anna Lundh, Vladimir Parpura, Robert E. McCullumsmith, Rammohan Shukla, Sinead M. O’Donovan
Publikováno v:
Cells, Vol 11, Iss 20, p 3315 (2022)
Astrocytes have many important functions in the brain, but their roles in psychiatric disorders and their responses to psychotropic medications are still being elucidated. Here, we used gene enrichment analysis to assess the relationships between dif
Externí odkaz:
https://doaj.org/article/32c40c538ad443aca32d1f9207a02e20
Autor:
Rawan Alnafisah, Anna Lundh, Sophie M. Asah, Julie Hoeflinger, Alyssa Wolfinger, Abdul-rizaq Hamoud, Robert E. McCullumsmith, Sinead M. O’Donovan
Publikováno v:
Schizophrenia. 8
ATP functions as a neurotransmitter, acting on the ubiquitously expressed family of purinergic P2 receptors. In schizophrenia (SCZ), the pathways that modulate extracellular ATP and its catabolism to adenosine are dysregulated. However, the effects o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b68c301d69dee9f27d1858965c0f4913
https://doi.org/10.1038/s41537-022-00312-1
https://doi.org/10.1038/s41537-022-00312-1
Autor:
Nicholas D. Henkel, Alex Joyce, Elizabeth Shedroff, Ali Sajid Imami, Khaled Alganem, Abdul-rizaq Hamoud, Chongchong Xu, Benjamin Siciliano, Tao Ma, Zhexing Wen, Robert E. McCullumsmith
Neurons and astrocytes derived from Alzheimer’s Disease (AD) patient induced pluripotent stem cells are an evolving technology used to study the pathogenesis and etiology of AD. As the utility of mouse models of AD are increasingly coming into ques
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57056b1342d731c743ec127bf6adb9f5
https://doi.org/10.1101/2022.06.14.496149
https://doi.org/10.1101/2022.06.14.496149
Autor:
Rawan Alnafisah, Zhexing Wen, Sinead M. O’Donovan, Robert E. McCullumsmith, Abdul-Rizaq Hamoud, Rammohan Shukla, Xiaolu Zhang
Publikováno v:
Neurochemical Research. 46:2715-2730
Astrocytes are the primary homeostatic cells of the central nervous system, essential for normal neuronal development and function, metabolism and response to injury and inflammation. Here, we review postmortem studies examining changes in astrocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d44d7c65cdfd02101b4fa0869defa4d0
https://doi.org/10.1007/s11064-020-03212-x
https://doi.org/10.1007/s11064-020-03212-x
Autor:
Michael P. Morran, Scott A. Miruzzi, Charles F. Hawk, Andrea L. Nestor-Kalinoski, Paul W. Erhardt, Samuel O. Adeosun, Terry D. Hinds, Kari L. Neifer, David E. Stec, Jeffrey G. Sarver, Abdul-Rizaq Hamoud, Robert E. McCullumsmith, Darren M. Gordon
Publikováno v:
J Biol Chem
Activation of lipid-burning pathways in the fat-storing white adipose tissue (WAT) is a promising strategy to improve metabolic health and reduce obesity, insulin resistance, and type II diabetes. For unknown reasons, bilirubin levels are negatively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec9bb06c3d69e4e8a8d839f5250cdae7
https://doi.org/10.1074/jbc.ra120.013700
https://doi.org/10.1074/jbc.ra120.013700
Autor:
Rammohan Shukla, Rawan Alnafisah, Scott A. Miruzzi, Justin F. Creeden, Abdul-Rizaq Hamoud, Khaled Alganem, Jaroslaw Meller, Robert E. McCullumsmith, James Reigle, Nicholas D. Henkel, Hunter M. Eby, Ali S Imami
Publikováno v:
Neuropsychopharmacology
CNS disorders, and in particular psychiatric illnesses, lack definitive disease-altering therapeutics. The limited understanding of the mechanisms driving these illnesses with the slow pace and high cost of drug development exacerbates this issue. Fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e0f8844518f322c04bf6529ba14e16
https://doi.org/10.1038/s41386-020-0752-6
https://doi.org/10.1038/s41386-020-0752-6
Autor:
Abdul-Rizaq Hamoud, Karen Bach, Ojal Kakrecha, Nicholas Henkel, Xiaojun Wu, Robert E. McCullumsmith, Sinead M. O’Donovan
Publikováno v:
International Journal of Molecular Sciences. 23:11835
For over a century, a complex relationship between schizophrenia diagnosis and development of many cancers has been observed. Findings from epidemiological studies are mixed, with reports of increased, reduced, or no difference in cancer incidence in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01bc8a5d4173e555e3c19f17bb7611b3
https://doi.org/10.3390/ijms231911835
https://doi.org/10.3390/ijms231911835
Autor:
Rawan Alnafisah, Khaled Alganem, Abdul-rizaq Hamoud, Ali Sajid Imami, Justin Creeden, William Rayn V, Alex A. Joyce, Robert McCullumsmith, Sinead O'Donovan
Publikováno v:
Biological Psychiatry. 91:S211-S212
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83c2c4a8577967d57f8365118c578abb
https://doi.org/10.1016/j.biopsych.2022.02.543
https://doi.org/10.1016/j.biopsych.2022.02.543