Novel nuclear role of HDAC6 in prognosis and therapeutic target for colorectal cancer

Autor: de Álava E, Combiz Khozoie, Andrew Silver, Nelofer Syed, Abdul-Salam Vb, Hontecillas-Prieto L, Rajaa El Bekay, Eric O. Aboagye, García-Domínguez Dj, Kevin O’Neill, He M, Khalid Shah, Nabil Hajji, Miguel Angel Burguillos, Kaliszczak M

Histone deacetylase 6 (HDAC6) inhibition is a potential treatment of a wide range of cancer types via the acetylation of diverse proteins in the cytoplasm. However, the regulation of histone acetylation and the maintenance of higher-order chromatin s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b760ea884f93bd5485d337a290e8a18
https://doi.org/10.1101/2020.11.02.356121

Tipifarnib prevents development of hypoxia-induced pulmonary hypertension

Autor: Duluc, L, Ahmetaj-Shala, B, Mitchell, J, Abdul Salam, VB, Mahomed, AS, Aldabbous, L, Oliver, E, Iannone, L, Dubois, OD, Storck, EM, Tate, EW, Zhao, L, Wilkins, MR, Wojciak-Stothard, B

Aims. RhoB plays a key role in the pathogenesis of hypoxia - induced pulmonary hypertension. Farne sylated RhoB promotes growth responses in cancer cells and we investigated whether inhibition of protein farnesylation will have a protective effect. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::0cf438496de5a4ce5873ff82c64cad10
http://hdl.handle.net/10044/1/43788

Intracellular Chloride Channels Regulate Endothelial Metabolic Reprogramming in Pulmonary Arterial Hypertension.

Autor: Alzaydi MM; National Heart and Lung Institute.; National Center for Biotechnology, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia., Abdul-Salam VB; National Heart and Lung Institute.; Centre for Cardiovascular Medicine and Device Innovation, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom., Whitwell HJ; National Phenome Centre and Imperial Clinical Phenotyping Centre, and.; Section of Bioanalytical Chemistry, Division of Systems Medicine, Department of Metabolism, Digestion, and Reproduction, and., Russomanno G; National Heart and Lung Institute.; Medical Research Council (MRC) Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular, and Integrative Biology, University of Liverpool, Liverpool, United Kingdom., Glynos A; Mitochondrial Biology Unit, Medical Research Council, University of Cambridge, Cambridge, United Kingdom; and., Capece D; Centre for Cell Signalling and Inflammation, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom., Szabadkai G; Cell and Developmental Biology, University College London, London, United Kingdom., Wilkins MR; National Heart and Lung Institute., Wojciak-Stothard B; National Heart and Lung Institute.

Publikováno v: American journal of respiratory cell and molecular biology [Am J Respir Cell Mol Biol] 2023 Jan; Vol. 68 (1), pp. 103-115.

Nanoscale Study of Calcium Handling Remodeling in Right Ventricular Cardiomyocytes Following Pulmonary Hypertension.

Autor: Medvedev R; From the Dipartimento di Cardiochirurgia, Università degli Studi di Verona, Ospedale Borgo Trento, Italy (R.M., G.F.).; National Heart and Lung Institute, Imperial College London, Du Cane Road, London W12 0NN, United Kingdom (R.M., J.L.S.-A., A.A.-L., E.D., V.B.A.S., B.W.-S., J.G.).; Humanitas Clinical and Research Center, Rozzano, Italy (R.M., T.S., M.M.)., Sanchez-Alonso JL; National Heart and Lung Institute, Imperial College London, Du Cane Road, London W12 0NN, United Kingdom (R.M., J.L.S.-A., A.A.-L., E.D., V.B.A.S., B.W.-S., J.G.)., Alvarez-Laviada A; National Heart and Lung Institute, Imperial College London, Du Cane Road, London W12 0NN, United Kingdom (R.M., J.L.S.-A., A.A.-L., E.D., V.B.A.S., B.W.-S., J.G.)., Rossi S; Dipartimento di Medicina e Chirurgia, Università degli Studi di Parma, Italy (S.R., M.M.)., Dries E; National Heart and Lung Institute, Imperial College London, Du Cane Road, London W12 0NN, United Kingdom (R.M., J.L.S.-A., A.A.-L., E.D., V.B.A.S., B.W.-S., J.G.).; Lab of Experimental Cardiology, University of Leuven, Belgium (E.D.)., Schorn T; Humanitas Clinical and Research Center, Rozzano, Italy (R.M., T.S., M.M.)., Abdul-Salam VB; National Heart and Lung Institute, Imperial College London, Du Cane Road, London W12 0NN, United Kingdom (R.M., J.L.S.-A., A.A.-L., E.D., V.B.A.S., B.W.-S., J.G.)., Trayanova N; Department of Biomedical Engineering and Alliance for Cardiovascular Diagnostic and Treatment Innovation; Johns Hopkins University; Baltimore, MD (N.T.)., Wojciak-Stothard B; National Heart and Lung Institute, Imperial College London, Du Cane Road, London W12 0NN, United Kingdom (R.M., J.L.S.-A., A.A.-L., E.D., V.B.A.S., B.W.-S., J.G.)., Miragoli M; Dipartimento di Medicina e Chirurgia, Università degli Studi di Parma, Italy (S.R., M.M.)., Faggian G, Gorelik J; National Heart and Lung Institute, Imperial College London, Du Cane Road, London W12 0NN, United Kingdom (R.M., J.L.S.-A., A.A.-L., E.D., V.B.A.S., B.W.-S., J.G.).

Publikováno v: Hypertension (Dallas, Tex. : 1979) [Hypertension] 2021 Feb; Vol. 77 (2), pp. 605-616. Date of Electronic Publication: 2020 Dec 28.

Author Correction: Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension.

Autor: Sindi HA; National Heart and Lung Institute, Imperial College London, London, UK.; University of Jeddah, College of Science, Department of Biology, Jeddah, Saudi Arabia., Russomanno G; National Heart and Lung Institute, Imperial College London, London, UK., Satta S; National Heart and Lung Institute, Imperial College London, London, UK., Abdul-Salam VB; National Heart and Lung Institute, Imperial College London, London, UK., Jo KB; National Heart and Lung Institute, Imperial College London, London, UK., Qazi-Chaudhry B; Department of Physics, King's College London UK, London, UK., Ainscough AJ; National Heart and Lung Institute, Imperial College London, London, UK., Szulcek R; Amsterdam UMC, VU University Medical Center, Department of Pulmonary Diseases, Amsterdam Cardiovascular Sciences (ACS), Amsterdam, The Netherlands., Bogaard HJ; Amsterdam UMC, VU University Medical Center, Department of Pulmonary Diseases, Amsterdam Cardiovascular Sciences (ACS), Amsterdam, The Netherlands., Morgan CC; National Heart and Lung Institute, Imperial College London, London, UK., Pullamsetti SS; Max Planck Institute for Heart and Lung Research, Department of Lung Development and Remodeling, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany.; Department of Internal MedicineUniversities of Giessen and Marburg Lung Center (UGMLC), Member of the DZL, Justus Liebig University, Giessen, Germany., Alzaydi MM; National Heart and Lung Institute, Imperial College London, London, UK.; National Center for Biotechnology, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia., Rhodes CJ; National Heart and Lung Institute, Imperial College London, London, UK., Piva R; Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy., Eichstaedt CA; Centre for Pulmonary Hypertension, Thoraxclinic, Institute for Human Genetics, University of Heidelberg, Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.; Laboratory of Molecular Genetic Diagnostics, Institute of Human Genetics, Heidelberg University, Heidelberg, Germany., Grünig E; Centre for Pulmonary Hypertension, Thoraxclinic, Institute for Human Genetics, University of Heidelberg, Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany., Wilkins MR; National Heart and Lung Institute, Imperial College London, London, UK., Wojciak-Stothard B; National Heart and Lung Institute, Imperial College London, London, UK. b.wojciak-stothard@imperial.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2020 Jun 30; Vol. 11 (1), pp. 3300. Date of Electronic Publication: 2020 Jun 30.