Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Abdul-Rahman B. Manas"'
Autor:
Robin A.J. Smith, Stephanie Brown, Meredith F. Ross, Abdul-Rahman B. Manas, Michael P. Murphy, Alejandra Sanjuan-Pla
Publikováno v:
Free Radical Biology and Medicine. 42:1766-1780
Lipoic acid (LA) is a widely used antioxidant that protects mitochondria from oxidative damage in vivo. Much of this protection is thought to be due to the reduction of LA to dihydrolipoic acid (LAH(2)). This reduction is catalyzed in vivo by thiored
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::864dd52e7de830581ab150f9e300d5b2
https://doi.org/10.1016/j.freeradbiomed.2007.02.033
https://doi.org/10.1016/j.freeradbiomed.2007.02.033
Autor:
Victoria J. Adlam, Andrew M. James, Geoffrey F. Kelso, Jordi Asin-Cayuela, Thabo Mahendiran, Robin A.J. Smith, Frances H. Blaikie, Helena M. Cochemé, Carolyn M. Porteous, Abdul-Rahman B. Manas, Michael P. Murphy, Meredith F. Ross, Jan Trnka
Publikováno v:
Mitochondrion. 7:S94-S102
Mitochondrial oxidative damage contributes to a range of degenerative diseases. Ubiquinones have been shown to protect mitochondria from oxidative damage, but only a small proportion of externally administered ubiquinone is taken up by mitochondria.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62e48aaad1299d2207edf2d86318dbe
https://doi.org/10.1016/j.mito.2007.02.007
https://doi.org/10.1016/j.mito.2007.02.007
Autor:
Frank E. Frerman, Abdul-Rahman B. Manas, Robin A.J. Smith, Judy Hirst, Michael P. Murphy, Mark S. Sharpley, Andrew M. James
Publikováno v:
Journal of Biological Chemistry. 282:14708-14718
MitoQ(10) is a ubiquinone that accumulates within mitochondria driven by a conjugated lipophilic triphenylphosphonium cation (TPP(+)). Once there, MitoQ(10) is reduced to its active ubiquinol form, which has been used to prevent mitochondrial oxidati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec23989a357b64ed0aa57a346014bc9b
https://doi.org/10.1074/jbc.m611463200
https://doi.org/10.1074/jbc.m611463200
Autor:
Helena M. Cochemé, Victoria J. Adlam, Aleksandra Filipovska, Andrew M. James, Bruce A. Jones, Abdul-Rahman B. Manas, Carolyn M. Porteous, Irina Abakumova, Tracy A. Prime, Meredith F. Ross, Angela Logan, Frances H. Blaikie, Robin A.J. Smith, Jan Trnka, Michael P. Murphy
Publikováno v:
Annals of the New York Academy of Sciences. 1147
Mitochondrial oxidative damage is thought to contribute to a wide range of human diseases; therefore, the development of approaches to decrease this damage may have therapeutic potential. Mitochondria-targeted antioxidants that selectively block mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a2a88d57f4c63af733407fae71d462
https://pubmed.ncbi.nlm.nih.gov/19076435
https://pubmed.ncbi.nlm.nih.gov/19076435
Autor:
Jordi Asin-Cayuela, Abdul-Rahman B. Manas, Andrew M. James, Michael P. Murphy, Robin A.J. Smith
Publikováno v:
FEBS Letters. (1-3):9-16
The mitochondria-targeted antioxidant MitoQ comprises a ubiquinol moiety covalently attached through an aliphatic carbon chain to the lipophilic triphenylphosphonium cation. This cation drives the membrane potential-dependent accumulation of MitoQ in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d55cfe7582681dfdb42de14e46fee85
Publikováno v:
J. Chem. Soc., Chem. Commun.. :216-217
Conjugate addition of (1) to unhindered αβ-unsaturated ketones proceeds in good yield to produce γ-keto-orthothioesters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ef6c6f2855b5ff3e8fa1c28773ce8e9
https://doi.org/10.1039/c39750000216
https://doi.org/10.1039/c39750000216