Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Abdul S. Ethayathulla"'
Autor:
Mounika Endrakanti, Jyoti Sharma, Mehar Chand Sharma, Abdul S. Ethayathulla, Punit Kaur, Shah Alam Khan, Madhulika Kabra
Publikováno v:
Genetics in Medicine Open, Vol 1, Iss 1, Pp 100214- (2023)
Externí odkaz:
https://doaj.org/article/79469ef0c3e54818bf2eaf9190acd15f
The p53 tumor suppressor is one of the most mutated genes responsible for tumorigenesis in most human cancers. Out of 29,891 genomic mutations reported in the TP53 Database (https://tp53.isb-cgc.org/), 1297 are identified as unique missense somatic m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5fe0f26cb1e02881cc35a3213f680f3
https://doi.org/10.1101/2023.02.06.527255
https://doi.org/10.1101/2023.02.06.527255
Autor:
Mukesh Kumar, Abdul S. Ethayathulla, Deepali Gupta, Punit Kaur, Mandeep Singh, Priyanka Sharma
Publikováno v:
Cellular and Molecular Life Sciences. 78:7967-7989
Since the emergence of the first case of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2), the viral genome has constantly undergone rapid mutations for better adaptation in the host system. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d6f1c5203e1e8dac32f7acb048fd00
https://doi.org/10.1007/s00018-021-04008-0
https://doi.org/10.1007/s00018-021-04008-0
Autor:
Tirthankar, Koley, Manoj, Kumar, Arunima, Goswami, Abdul S, Ethayathulla, Gururao, Hariprasad
Publikováno v:
Biochemical and Biophysical Research Communications
Omicron is a new variant of SARS-CoV-2, which is currently infecting people around the world. Spike glycoprotein, an important molecule in pathogenesis of infection has been modeled and the interaction of its Receptor Binding Domain with human ACE-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b49ab420927117cf4cc6d489fd88927
https://doi.org/10.1016/j.bbrc.2021.12.082
https://doi.org/10.1016/j.bbrc.2021.12.082
Publikováno v:
Molecular Diversity
The accumulation of massive data in the plethora of Cheminformatics databases has made the role of big data and artificial intelligence (AI) indispensable in drug design. This has necessitated the development of newer algorithms and architectures to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::363f7348c459fad001263b0fcbdc1fae
https://doi.org/10.1007/s11030-021-10256-w
https://doi.org/10.1007/s11030-021-10256-w
Autor:
Lakshay Malhotra, Punit Kaur, Valeria A. Litvinova, Mandeep Singh, Mukesh Kumar, Alexander S. Tikhomirov, Uddipan Das, Andrey E. Shchekotikhin, Alexander M. Korolev, Anzarul Haque, Abdul S. Ethayathulla
Publikováno v:
Biochimie. 182:152-165
The quest for effective anticancer therapeutics continues to be extensively pursued. Over the past century, several drugs have been developed, however, a majority of these drugs have a poor therapeutic index and increased toxicity profile. Hence, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99dcd96352c72a48465ef064a3dc41a2
https://doi.org/10.1016/j.biochi.2020.12.024
https://doi.org/10.1016/j.biochi.2020.12.024
Publikováno v:
Briefings in functional genomics.
The p53 is the master regulator of the cell known for regulating a large array of cellular processes. Inactivation of p53 by missense mutations is one of the leading causes of cancer. Some of these mutations endow p53 with selective oncogenic functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a5ed0dad824a90845896e6808d94e8
https://pubmed.ncbi.nlm.nih.gov/35809339
https://pubmed.ncbi.nlm.nih.gov/35809339
Autor:
Lakshay Malhotra, Saurabh Sharma, Gururao Hariprasad, Renu Dhingra, Vandana Mishra, Radhey S. Sharma, Punit Kaur, Abdul S. Ethayathulla
Publikováno v:
Biochimica et biophysica acta. Molecular cell research. 1869(12)
The mutant p53Y220C (mutp53Y220C) is frequently observed in numerous tumors, including pancreatic cancer. The mutation creates a crevice in the DNA binding core domain and makes p53 a thermally unstable non-functional protein that assists tumor progr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f9f9b01ab60cf6732a2857be35d8228
https://pubmed.ncbi.nlm.nih.gov/36007676
https://pubmed.ncbi.nlm.nih.gov/36007676
Autor:
Abdul S. Ethayathulla, Sujata Sharma, Tej P. Singh, Pushpendra Singh, Punit Kaur, Manish Kumar Tripathi
Publikováno v:
Journal of Biomolecular Structure & Dynamics
article-version (VoR) Version of Record
Journal of Biomolecular Structure and Dynamics
article-version (VoR) Version of Record
Journal of Biomolecular Structure and Dynamics
SARS-CoV-2 is the causative agent of COVID-19 and has been declared as pandemic disease by World Health Organization. Lack of targeted therapeutics and vaccines for COVID-2019 have triggered the scientific community to develop new vaccines or drugs a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9617a343ec9b3b18f130118e1b48777
http://europepmc.org/articles/PMC7441797
http://europepmc.org/articles/PMC7441797
Autor:
Shivani Madaan, Tej P. Singh, Sanghati Roy Chowdhury, Tirthankar Koley, Punit Kaur, Manoj Kumar, Abdul S. Ethayathulla
Publikováno v:
3 Biotech
The pandemic COVID-19 was caused by a novel Coronavirus-2 (SARS-CoV-2) that infects humans through the binding of glycosylated SARS-CoV-2 spike 2 protein to the glycosylated ACE2 receptor. The spike 2 protein recognizes the N-terminal helices of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9e8b99543d875f5b32697948b4e2fc
https://doi.org/10.21203/rs.3.rs-98738/v1
https://doi.org/10.21203/rs.3.rs-98738/v1