Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Abdul Q, Sheikh"'
Autor:
Rachana R. Chandran, Yi Xie, Eunate Gallardo-Vara, Taylor Adams, Rolando Garcia-Milian, Inamul Kabir, Abdul Q. Sheikh, Naftali Kaminski, Kathleen A. Martin, Erica L. Herzog, Daniel M. Greif
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The pluripotency factor KLF4 has been described as pro-fibrotic or anti-fibrotic in various diseases. Herein, the authors show that during lung fibrosis, these distinct effects can be attributed to mesenchymal cell-type specific functions of KLF4.
Externí odkaz:
https://doaj.org/article/bfacbe42ada44a45abedd4f53adc3c31
Autor:
Ashish Misra, Zhonghui Feng, Rachana R. Chandran, Inamul Kabir, Noemi Rotllan, Binod Aryal, Abdul Q. Sheikh, Ling Ding, Lingfeng Qin, Carlos Fernández-Hernando, George Tellides, Daniel M. Greif
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Smooth muscle cells (SMCs) invade atherosclerotic lesions and expand, contributing to plaque progression. Here Misra et al. show that SMC-derived plaque cells come from a single SMC and integrin β3 in SMCs and macrophages regulate the fate, expansio
Externí odkaz:
https://doaj.org/article/6e7f80388c9f44268ac8ad087346132a
Publikováno v:
Cell Reports, Vol 23, Iss 4, Pp 1152-1165 (2018)
Summary: Pulmonary hypertension is a devastating disease characterized by excessive vascular muscularization. We previously demonstrated primed platelet-derived growth factor receptor β+ (PDGFR-β+)/smooth muscle cell (SMC) marker+ progenitors at th
Externí odkaz:
https://doaj.org/article/de15bf94d0274ef7979a6df5b1da8b6e
Publikováno v:
Cell Reports, Vol 6, Iss 5, Pp 809-817 (2014)
Excess smooth muscle accumulation is a key component of many vascular disorders, including atherosclerosis, restenosis, and pulmonary artery hypertension, but the underlying cell biological processes are not well defined. In pulmonary artery hyperten
Externí odkaz:
https://doaj.org/article/259e8720d3884f6989abb29ac629f5e5
Autor:
Abdul Q Sheikh, Jennifer R Hurley, Wei Huang, Toloo Taghian, Andrei Kogan, Hongkwan Cho, Yigang Wang, Daria A Narmoneva
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36840 (2012)
Diabetic cardiomyopathy (DCM) is a diabetic complication, which results in myocardial dysfunction independent of other etiological factors. Abnormal intracellular calcium ([Ca(2+)](i)) homeostasis has been implicated in DCM and may precede clinical m
Externí odkaz:
https://doaj.org/article/b1df6052fb4446c88a61bed77e0fd405
Autor:
Carlos Fernández-Hernando, Inamul Kabir, Zhonghui Feng, Lingfeng Qin, Abdul Q. Sheikh, Ling Ding, George Tellides, Daniel Greif, Noemi Rotllan, Ashish Misra, Binod Aryal, Rachana Radhamani Chandran
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Nature Communications
Smooth muscle cells (SMCs) play a key role in atherogenesis. However, mechanisms regulating expansion and fate of pre-existing SMCs in atherosclerotic plaques remain poorly defined. Here we show that multiple SMC progenitors mix to form the aorta dur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3f3e40a819a655da43959a7c16a893
http://link.springer.com/article/10.1038/s41467-018-04447-7
http://link.springer.com/article/10.1038/s41467-018-04447-7
Autor:
Timothy M. Crombleholme, Abdul Q. Sheikh, Swathi Balaji, Hongkwan Cho, Daria A. Narmoneva, Natalie L. Hone, Chad M. Moles, Sundeep G. Keswani
Publikováno v:
Wound Repair and Regeneration. 24:829-840
Reduced mobilization of endothelial progenitor cells (EPCs) from the bone marrow (BM) and impaired EPC recruitment into the wound represent a fundamental deficiency in the chronic ulcers. However, mechanistic understanding of the role of BM-derived E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::090fe1c5779cefc36866a82fbf787503
https://doi.org/10.1111/wrr.12453
https://doi.org/10.1111/wrr.12453
Autor:
Abdul Q. Sheikh, Robert B. Hinton, Wei Huang, Jennifer R. Hurley, Courtney Kuesel, Toloo Taghian, Daria A. Narmoneva, Yigang Wang
Publikováno v:
American Journal of Physiology-Cell Physiology. 306:C768-C778
Diabetes-induced cardiomyopathy is characterized by cardiac remodeling, fibrosis, and endothelial dysfunction, with no treatment options currently available. Hyperglycemic memory by endothelial cells may play the key role in microvascular complicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d1716b3abe9df7175d508ad2e6627c
https://doi.org/10.1152/ajpcell.00201.2013
https://doi.org/10.1152/ajpcell.00201.2013
Autor:
Ashish Misra, R Mazurek, Jui M. Dave, Abdul Q. Sheikh, Rachana Radhamani Chandran, Daniel Greif
The vessel wall is composed of distinct cellular layers, yet communication among individual cells within and between layers results in a dynamic and versatile structure. The morphogenesis of the normal vascular wall involves a highly regulated proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfff130cb487bdaba3f4d8a2eaf95ca6
https://doi.org/10.1016/bs.apha.2016.08.001
https://doi.org/10.1016/bs.apha.2016.08.001
Publikováno v:
Cellular and Molecular Bioengineering. 5:173-183
Overcoming the effects of hyperglycemic conditions on matrix remodeling by cardiac fibroblasts represents a novel therapeutic approach to stimulate regeneration of cardiac tissue in the context of diabetes. The purpose of this study was to investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c55b071ed68a9845f2471c11f92a083f
https://doi.org/10.1007/s12195-012-0222-2
https://doi.org/10.1007/s12195-012-0222-2