Cardiovascular magnetic resonance predicts all-cause mortality in pulmonary hypertension associated with heart failure with preserved ejection fraction

Autor: Smitha Rajaram, Alexander M.K. Rothman, Andrew J. Swift, Christopher S. Johns, Jim M. Wild, Robin Condliffe, Abdul G. Hameed, David Capener, Charlie Elliot, Robert A. Lewis, Pankaj Garg, David G. Kiely, A. A. Roger Thompson, Athanasios Charalampopoulos

Publikováno v: The International Journal of Cardiovascular Imaging

This study aimed to determine the prognostic value of cardiovascular magnetic resonance (CMR) in patients with heart failure with preserved ejection fraction and associated pulmonary hypertension (pulmonary hypertension-HFpEF). Patients with pulmonar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e561e5d38647d88f487908731da2802
https://ueaeprints.uea.ac.uk/id/eprint/82094/

EmPHasis-10 health-related quality of life score predicts outcomes in patients with idiopathic and connective tissue disease-associated pulmonary arterial hypertension: results from a UK multi-centre study

Autor: Robert Lewis, Iain Armstrong, Carmel Bergbaum, Melanie J Brewis, John Cannon, Athanasios Charalampopoulos, A Colin Church, J Gerry Coghlan, Rachel Davies, Konstantinos Dimopoulos, Charlie Elliot, J Simon R Gibbs, Wendy Gin-Sing, Gulam Haji, Abdul G Hameed, Luke S Howard, Martin K Johnson, Aleksander Kempny, David G Kiely, Francesco Lo Giudice, Colm Mccabe, Oyinkansola Peleyeju, Joanna Pepke-Zaba, Gary Polwarth, Laura Price, Ian Sabroe, Benjamin E Schreiber, Karen Sheares, Dolores Taboada, A A Roger Thompson, Mark R Toshner, Ivy Wanjiku, S John Wort, Janelle Yorke, Robin Condliffe

Health-related quality of life (HRQoL) scores assess symptom burden in pulmonary arterial hypertension (PAH) but data regarding their role in prognostication and risk stratification are limited. We assessed these relationships using the emPHasis-10 H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e2ee513c71e8133ba1808bcb8747e1
https://www.repository.cam.ac.uk/handle/1810/317873

Percent-predicted incremental shuttle walking test distance stratifies risk in pulmonary arterial hypertension

Autor: Robert A. Lewis, Judith Hurdman, A. A. Roger Thompson, Iain Armstrong, Ian Sabroe, Emma Drew, Athanasios Charalampopoulos, Catherine Billings, David G. Kiely, Abdul G. Hameed, Jim M. Wild, Alexander M.K. Rothman, Andrew J. Swift, Neil Hamilton, John Harrington, Robin Condliffe, Ian Smith, Allan Lawrie, Charlie Elliot, Jennifer Middleton, Matthew Austin, Tom Kelly

Publikováno v: Pulmonary hypertension.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d677f255641f8c3f7a54efd24be720c
https://doi.org/10.1183/13993003.congress-2020.1497

Hypoxia determines survival outcomes of bacterial infection through HIF-1alpha dependent re-programming of leukocyte metabolism *

Autor: Massimiliano Mazzone, Ananda S. Mirchandani, Simon J. Foster, David H. Dockrell, Peter Carmeliet, Emily R. Watts, Nadine Arnold, Joseph A Willson, Lynne Williams, Federico Taverna, Rebecca S. Dickinson, Pranvera Sadiku, Nicholas M. Morton, Catherine J. Doherty, A. A. Roger Thompson, Sarah R. Walmsley, Veronica Finisguerra, Edwin R. Chilvers, Amy Lewis, Shareen Forbes, Helen M. Marriott, Patricia Dos Santos Coelho, Randall S. Johnson, John P. Thomson, Moira K. B. Whyte, Julie A. Preston, Allan Lawrie, Fiona Murphy, Andrew S. Cowburn, Richard R. Meehan, Roland H Stimson, Jermaine Goveia, Abdul G. Hameed, Eilise M. Ryan, Adriana Tavares

Publikováno v: Thompson, A A R, Dickinson, R S, Murphy, F, Thomson, J P, Marriott, H M, Tavares, A, Willson, J, Williams, L, Lewis, A, Mirchandani, A, Dos Santos Coelho, P, Doherty, C, Ryan, E, Watts, E, Morton, N M, Forbes, S, Stimson, R H, Hameed, A G, Arnold, N, Preston, J A, Lawrie, A, Finisguerra, V, Mazzone, M, Sadiku, P, Goveia, J, Taverna, F, Carmeliet, P, Foster, S J, Chilvers, E R, Cowburn, A S, Dockrell, D H, Johnson, R S, Meehan, R R, Whyte, M K B & Walmsley, S R 2017, ' Hypoxia determines survival outcomes of bacterial infection through HIF-1α–dependent reprogramming of leukocyte metabolism ', Science Immunology, vol. 2, no. 8, eaal2861 . https://doi.org/10.1126/sciimmunol.aal2861

Hypoxia and bacterial infection frequently coexist, in both acute and chronic clinical settings, and typically result in adverse clinical outcomes. To ameliorate this morbidity, we investigated the interaction between hypoxia and the host response. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b31b381051dc9e5a6366f78a268326
https://europepmc.org/articles/PMC5380213/

Inhibition of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension

Autor: Nadine Arnold, Lan Zhao, Simon S. Cross, Janet Chamberlain, David G. Kiely, David C. Crossman, Lu Long, Nicholas W. Morrell, Claudia Paiva, Josephine A. Pickworth, Allan Lawrie, Sarah Dawson, Chris Newman, Sheila E. Francis, Abdul G. Hameed

Publikováno v: The Journal of Experimental Medicine

Genetic deletion of TRAIL or antibody blockade prevents the development of pulmonary arterial hypertension and can reverse vascular remodeling in established disease.
Pulmonary arterial hypertension (PAH) is a life-threatening disease characteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081f9ef71d60f6c10c69555102586e4a
https://doi.org/10.1084/jem.20112716