Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Abdu I Alayash"'
Evaluation of Stem Cell-Derived Red Blood Cells as a Transfusion Product Using a Novel Animal Model.
Autor:
Sandeep N Shah, Monique P Gelderman, Emily M A Lewis, John Farrel, Francine Wood, Michael Brad Strader, Abdu I Alayash, Jaroslav G Vostal
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0166657 (2016)
Reliance on volunteer blood donors can lead to transfusion product shortages, and current liquid storage of red blood cells (RBCs) is associated with biochemical changes over time, known as 'the storage lesion'. Thus, there is a need for alternative
Externí odkaz:
https://doaj.org/article/5f12657998fd4fa198fa9429ad7608e4
Autor:
Elena eKarnaukhova, Sigurbjörg eRutardottir, Mohsen eRajabi, Lena eWester Rosenlöf, Abdu I Alayash, Bo eÅkerström
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
Background: Alpha-1-microglobulin (A1M), a small lipocalin protein found in plasma and tissues, has been identified as a heme and radical scavenger that may participate in the mitigation of toxicities caused by degradation of hemoglobin. The objectiv
Externí odkaz:
https://doaj.org/article/dcf28399b4904e75b31a3975174e82a7
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Introduction: Electrostatic binding of deoxyhemoglobin (Hb) to cytoplasmic domain of band 3 anion transport protein occurs as part of the glycolytic regulation in red blood cells (RBCs). Hb oxidation intermediates not only impact RBC’s oxygenation
Externí odkaz:
https://doaj.org/article/a2e91ea9b5014c82b05557798fad4718
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59841 (2013)
Human hemoglobin (Hb) and haptoglobin (Hp) exhibit an extremely high affinity for each other, and the dissociation of Hb tetramers into dimers is generally believed to be a prerequisite for complex formation. We have investigated Hp interactions with
Externí odkaz:
https://doaj.org/article/8c83054bf6324cc493f7d9d0c90c3b62
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Red blood cells (RBCs) undergo metabolic, oxidative, and physiological changes during storage, collectively described as the “storage lesion.” The impact of storage on oxygen homeostasis, following transfusion, is not fully understood. We show th
Externí odkaz:
https://doaj.org/article/d406247457614ef7b75f0f060bf22937
Publikováno v:
FEBS Open Bio, Vol 11, Iss 12, Pp 3293-3303 (2021)
It is well documented that caffeic acid (3,4‐dihydroxycinnamic acid) (CA) interacts with and inhibits the oxidative reactions of myoglobin (Mb) and hemoglobin (Hb), and this interaction underlies its antioxidative action in meat. Sickle cell hemogl
Externí odkaz:
https://doaj.org/article/9b339d0f101547138ceaf5690cc514db
Autor:
Abdu I. Alayash
Publikováno v:
Frontiers in Medical Technology, Vol 4 (2022)
Oxygen reversibly binds to the redox active iron, a transition metal in human Hemoglobin (Hb), which subsequently undergoes oxidation in air. This process is akin to iron rusting in non-biological systems. This results in the formation of non-oxygen
Externí odkaz:
https://doaj.org/article/ee268be5ffbb410181d5d1813d96b92f
Autor:
Abdu I. Alayash, Michael T. Wilson
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/f928ee1cb75b4dd6ad641ef059d93873
Publikováno v:
Redox Report, Vol 25, Iss 1, Pp 95-103 (2020)
The β subunit substitutions, F41Y and K82D, in sickle cell hemoglobin (Hb) (βE6 V) provides significant resistance to oxidative stress by shielding βCys93 from the oxidizing ferryl heme. We evaluated the oxidative resistance of βCys93 to hydrogen
Externí odkaz:
https://doaj.org/article/b29b1e68b2e04a4587a062e013d891e0
Autor:
Abdu I. Alayash
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
The novel coronavirus (2019-nCoV/SARS-CoV-2) causes respiratory symptoms including a substantial pulmonary dysfunction with worsening arterial hypoxemia (low blood oxygenation), eventually leading to acute respiratory distress syndrome (ARDS). The im
Externí odkaz:
https://doaj.org/article/9ff5ed90a0e14067b5eae72e24fca992